2-(2,6-difluorophenylamino)pyridine | 227805-80-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(2,6-difluorophenylamino)pyridine
• 英文别名: 2-(2,6-difluoroanilino)pyridine；H(2,6-F2ap)；2-Pyridinamine, N-(2,6-difluorophenyl)-；N-(2,6-difluorophenyl)pyridin-2-amine
• CAS: 227805-80-3
• 化学式: C₁₁H₈F₂N₂
• 分子量: 206.195
• InChiKey: RURSBHJOXFXOPE-UHFFFAOYSA-N

物化性质

• 沸点：
  242.4±35.0 °C(Predicted)
• 密度：
  1.312±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  24.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(2,6-difluorophenylamino)pyridine 、 四氯化钛 在 NaH 作用下， 以 乙醚 、 甲苯 为溶剂， 以89%的产率得到bis(2,6-difluorophenylaminopyridinato) titanium dichloride
  参考文献：
  名称：

  Synthesis, characterization and ethylene polymerization activity of titanium aminopyridinato complexes

  摘要：

  Three titanium complexes derived from 2-(2,6-difluoroanilino) pyridine and 2-(2- chloroanilino) pyridine were synthesized and characterized by X-ray diffraction or spectroscopic methods. All titanium complexes have been used to catalyze the polymerization of ethylene in the presence of MAO as cocatalyst. The mono(2,6- difluorophenylaminopyridinato) titanium catalyst was found to be more active in ethylene polymerization than the bis(2,6- difluorophenylaminopyridinato) and bis(2- chlorophenylaminopyridinato) titanium catalysts. ortho-Halogens disturbed the beta-elimination transition state of ethylene polymerization and formed higher molar mass polyethylene than their unhalogenated congener. Due to fluxionality, the bis(2- chlorophenylaminopyridinato) titanium catalyst formed broader molar mass distribution than the bis(2,6- difluorophenylaminopyridinato) titanium catalysts. (C) 2007 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ica.2007.11.028
• 作为产物：
  描述：

  2-氯吡啶 、 2,6-二氟苯胺 在 potassium tert-butylate 、 C₆₆H₉₂Cl₃N₃Pd 作用下， 以 正庚烷 为溶剂， 反应 4.0h， 以48%的产率得到2-(2,6-difluorophenylamino)pyridine
  参考文献：
  名称：

  Buchwald‐Hartwig Amination of Coordinating Heterocycles Enabled by Large‐but‐Flexible Pd‐BIAN‐NHC Catalysts**

  摘要：

  AbstractA new class of large‐but‐flexible Pd‐BIAN‐NHC catalysts (BIAN=acenaphthoimidazolylidene, NHC=N‐heterocyclic carbene) has been rationally designed to enable the challenging Buchwald‐Hartwig amination of coordinating heterocycles. This robust class of BIAN‐NHC catalysts permits cross‐coupling under practical aerobic conditions of a variety of heterocycles with aryl, alkyl, and heteroarylamines, including historically challenging oxazoles and thiazoles as well as electron‐deficient heterocycles containing multiple heteroatoms with BIAN‐INon (N,N′‐bis(2,6‐di(4‐heptyl)phenyl)‐7H‐acenaphtho[1,2‐d]imidazol‐8‐ylidene) as the most effective ligand. Studies on the ligand structure and electronic properties of the carbene center are reported. The study should facilitate the discovery of even more active catalyst systems based on the unique BIAN‐NHC scaffold.

  DOI：

  10.1002/chem.202103341

文献信息

• Factors Affecting the Electrochemical and Spectroelectrochemical Properties of Diruthenium(III,II) Complexes Containing Four Identical Unsymmetrical Bridging Ligands
  作者：Karl M. Kadish、Li-Lun Wang、Antoine Thuriere、Eric Van Caemelbecke、John L. Bear

  DOI：10.1021/ic020590x

  日期：2003.2.1

  species described in the literature. The Ru-Ru bond lengths of the four structurally characterized (4,0) isomers of the ap complexes range from 2.275 to 2.296 A while those of the three structurally characterized (3,1) isomers of ap derivatives fall in the range 2.284-2.286 A and show no significant difference among the three compounds. The Ru-Cl bond lengths of the (3,1) isomers do not vary significantly

  对于包含四种不对称桥接配体的钌（III，II）配合物的电化学和光谱电化学性质的影响因素，已针对以七个可能的异构体形式中的一种或两种分离出的七个相关化合物进行了报道。研究的化合物表示为Ru（2）（2-CH（3）ap）（4）Cl，Ru（2）（2,5-F（2）ap）（4）Cl，Ru（2）（2 ，6-F（2）ap）（4）Cl和Ru（2）（2,4,6-F（3）ap）（4）Cl其中2-CH（3）ap，2,5-F （2）ap，2,6-F（2）ap和2,4,6-F（3）ap分别是2-（2-甲基苯胺基）吡啶鎓阴离子，2-（2,5-二氟苯胺基）吡啶酸根阴离子，2-（2,6-二氟苯胺基）吡啶酸根阴离子和2-（2,4,6-三氟苯胺基）吡啶酸根阴离子。Ru（2）（2-CH（3）ap）（4）Cl和Ru（2）（2,5-F（2）ap）（4）Cl仅以（4,0）构象存在，而Ru（2 2）（2,4,6-F（3）ap）（4）Cl以（3
• Substituent and Isomer Effects on Structural, Spectroscopic, and Electrochemical Properties of Dirhodium(III,II) Complexes Containing Four Identical Unsymmetrical Bridging Ligands
  作者：Karl M. Kadish、Tuan D. Phan、Lingamallu Giribabu、Eric Van Caemelbecke、John L. Bear

  DOI：10.1021/ic034963l

  日期：2003.12.1

  Substituent and isomer effects on the structural, spectroscopic, (UV-visible and ESR) and electrochemical properties of dirhodium(III,II) complexes containing four identical unsymmetrical bridging ligands are reported for seven related compounds of the type Rh(2)(L)(4)Cl where L = 2-(2-fluoroanilino)pyridinate (2-Fap), 2-(2,6-difluoroanilino)pyridinate (2,6-F(2)ap), 2-(2,4,6-trifluoroanilino)pyridinate

  取代基和异构体对含有四个相同不对称桥键配体的铑（III，II）配合物的结构，光谱，（紫外可见和ESR）和电化学性质的影响已针对Rh（2）（L）类型的七个相关化合物进行了报道。 （4）Cl，其中L = 2-（2-氟苯胺基）吡啶鎓（2-Fap），2-（2,6-二氟苯胺基）吡啶鎓（2,6-F（2）ap），2-（2,4， 6-三氟苯胺基吡啶（2,4,6-F（3）ap）或2-（2,3,4,5,6-五氟苯胺基）吡啶（F（5）ap）阴离子。Rh（2）（2-Fap）（4）Cl仅以（4,0）异构构象存在，而Rh（2）（2,6-F（2）ap）（4）Cl，Rh（2）（ 2,4,6-F（3）ap）（4）Cl和Rh（2）（F（5）ap）（4）Cl以（4,0）和（3,1）异构体形式存在。先前已经证明Rh（2）（L）（4）Cl配合物可以采用桥联配体的不同几何构型，但是当前的研究提供了第一个示例，其中使用相同的合成步骤为
• 3-PIPERIDYL-4-OXOQUINAZOLINE DERIVATIVES AND MEDICINCAL COMPOSITIONS CONTAINING THE SAME
  申请人：Japan Tobacco Inc.

  公开号：EP0970954A1

  公开（公告）日：2000-01-12

  3-piperidyl-4-oxoquinazoline derivatives are provided, which is represented by the formula (I): wherein R represents an amino group or a cyclic amino group such as dibenzoazepine, each of which is substituted with a substituted or unsubstituted aryl group, a substituted or unsubstituted heteroaryl group, or the like, n is an integer of 1 to 4, R3 and R4 independently represents a hydrogen atom, a lower alkyl group, or the like, or a pharmaceutically acceptable salt thereof. Compounds (I) of the present invention have excellent MTP-inhibitory activity. Thus, these compounds not only inhibit formation of LDL that is a cause of arteriosclerotic diseases but also regulate TG, cholesterol, and lipoproteins such as LDL in the blood and regulate cellular lipids through regulation of MTP activity. They can also be used as a new type of preventive or therapeutic agents for hyperlipemia or arteriosclerotic diseases. Furthermore, they can be used as therapeutic or preventive agents for pancreatitis, obesity, hypercholesterolemia, and hypertriglyceridemia.

  提供了3-哌啶基-4-氧代喹唑啉衍生物，由式(I)表示： 其中 R 代表氨基或环状氨基，如二苯并氮杂卓，它们各自被取代或未被取代的芳基、取代或未被取代的杂芳基或类似基团取代，n 是 1 至 4 的整数，R3 和 R4 独立地代表氢原子、低级烷基或类似基团，或其药学上可接受的盐。本发明的化合物（I）具有优异的 MTP 抑制活性。因此，这些化合物不仅能抑制导致动脉硬化疾病的低密度脂蛋白的形成，还能调节血液中的总胆固醇、胆固醇和脂蛋白（如低密度脂蛋白），并通过调节 MTP 活性来调节细胞脂质。它们还可用作高脂血症或动脉硬化疾病的新型预防或治疗药物。此外，它们还可用作胰腺炎、肥胖症、高胆固醇血症和高甘油三酯血症的治疗或预防药物。
• US6235730B1
  申请人：——

  公开号：US6235730B1

  公开（公告）日：2001-05-22