[2-[[Pent-4-enyl(prop-2-enyl)amino]methyl]phenyl] 2-diazo-3-oxobutanoate | 406725-65-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 英文名称: [2-[[Pent-4-enyl(prop-2-enyl)amino]methyl]phenyl] 2-diazo-3-oxobutanoate
• 英文别名: [2-[[pent-4-enyl(prop-2-enyl)amino]methyl]phenyl] 2-diazo-3-oxobutanoate
• CAS: 406725-65-3
• 化学式: C₁₉H₂₃N₃O₃
• 分子量: 341.41
• InChiKey: BEYAFWYHRSPWGE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  25
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  48.6
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  [2-[[Pent-4-enyl(prop-2-enyl)amino]methyl]phenyl] 2-diazo-3-oxobutanoate 在 六氟乙酰丙酮化铜的水合物 作用下， 以 苯 为溶剂， 以72%的产率得到3-Acetyl-3-allyl-4-pent-4-enyl-4,5-dihydro-3H-benzo[f][1,4]oxazepin-2-one
  参考文献：
  名称：

  Synthesis of Novel α-Substituted and α,α-Disubstituted Amino Acids by Rearrangement of Ammonium Ylides Generated from Metal Carbenoids

  摘要：

  [GRAPHICS]A new and general four-step synthesis of protected alpha-substituted and alpha,alpha-disubstituted amino acids has been developed. The key step involves intramolecular ammonium ylide generation from a copper carbenoid with concomitant [2,3] rearrangement. The aromatic template serves as a tether, protecting group, and activating group for peptide coupling. The ylide rearrangement products can be converted into protected cyclic amino acids by ring-closing metathesis.

  DOI：

  10.1021/ol017240j
• 作为产物：
  描述：

  2-[N-(prop-2'-enyl)aminomethyl]phenol 在 4-乙酰氨基苯磺酰叠氮 、 potassium carbonate 、 三乙胺 、 sodium iodide 作用下， 以 N,N-二甲基甲酰胺 、 乙腈 为溶剂， 生成 [2-[[Pent-4-enyl(prop-2-enyl)amino]methyl]phenyl] 2-diazo-3-oxobutanoate
  参考文献：
  名称：

  Synthesis of Novel α-Substituted and α,α-Disubstituted Amino Acids by Rearrangement of Ammonium Ylides Generated from Metal Carbenoids

  摘要：

  [GRAPHICS]A new and general four-step synthesis of protected alpha-substituted and alpha,alpha-disubstituted amino acids has been developed. The key step involves intramolecular ammonium ylide generation from a copper carbenoid with concomitant [2,3] rearrangement. The aromatic template serves as a tether, protecting group, and activating group for peptide coupling. The ylide rearrangement products can be converted into protected cyclic amino acids by ring-closing metathesis.

  DOI：

  10.1021/ol017240j

文献信息

• Synthesis of Novel α-Substituted and α,α-Disubstituted Amino Acids by Rearrangement of Ammonium Ylides Generated from Metal Carbenoids
  作者：J. Stephen Clark、Mark D. Middleton

  DOI：10.1021/ol017240j

  日期：2002.3.1

  [GRAPHICS]A new and general four-step synthesis of protected alpha-substituted and alpha,alpha-disubstituted amino acids has been developed. The key step involves intramolecular ammonium ylide generation from a copper carbenoid with concomitant [2,3] rearrangement. The aromatic template serves as a tether, protecting group, and activating group for peptide coupling. The ylide rearrangement products can be converted into protected cyclic amino acids by ring-closing metathesis.