phenylethyltrimethylammonium chloride | 75337-06-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: phenylethyltrimethylammonium chloride
• 英文别名: trimethyl-phenethyl-ammonium; chloride；Trimethyl-phenaethyl-ammonium; Chlorid；N,N,N-Trimethyl-2-phenylethan-1-aminium chloride；trimethyl(2-phenylethyl)azanium;chloride
• CAS: 75337-06-3
• 化学式: C₁₁H₁₈N*Cl
• 分子量: 199.724
• InChiKey: KUSDSMLUXMFMCB-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -1.06
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  phenylethyltrimethylammonium chloride 在 氢气 作用下， 以 水 为溶剂， 生成 乙基苯 、 三甲胺
  参考文献：
  名称：

  Achmatowicz; Lindenfeld, Roczniki Chemii, 1938, vol. 18, p. 69,72

  摘要：

  DOI：

文献信息

• Multipoint Recognition of Catecholamines by Hydrindacene-Based Receptors Accompanied by the Complexation-Induced Conformational Switching
  作者：Hidetoshi Kawai、Ryo Katoono、Kenshu Fujiwara、Takashi Tsuji、Takanori Suzuki

  DOI：10.1002/chem.200400819

  日期：2005.1.21

  The molecular recognition of catecholamines by hydrindacene-based receptors 1 and 2, as well as the durene-based receptor 3, and the guest-induced conformational changes are reported. These receptors selectively bind adrenaline and dopamine salts through the guests' ammonium group and 3-hydroxyl group on the aromatic ring. In the case of adrenaline, an additional hydrogen bond with a benzylic hydroxyl

  据报道，基于苯并二氢萘的受体1和2以及基于聚对二甲苯的受体3对儿茶酚胺的分子识别以及客体诱导的构象变化。这些受体通过客人的铵基和芳香环上的3-羟基选择性地结合肾上腺素和多巴胺盐。在肾上腺素的情况下，形成具有苄基羟基的另外的氢键。在2％CD3CN / CDCl3中，缔合常数约为10（4）M（-1），这比没有3-羟基的来宾（10（3）M（-1））大得多。受体1的两个酰胺基可以围绕C（芳族）-C（酰胺）键自由旋转，而2中的叔酰胺以足够慢的速率在两个稳定的构象之间变化，以允许通过（1）H NMR进行检测光谱学。在没有客体分子的情况下，syn-conformer的稳定性低于反-conformer的稳定性。与肾上腺素形成复合物时，除多点氢键外，由于分子内偶极子逆转效应，顺式构象异构体也占主导地位。
• Novel Method for Preparation of Ammonium Salts of Esomeprazole
  申请人：Bergman Rolf

  公开号：US20090197919A1

  公开（公告）日：2009-08-06

  The present invention relates to a process for the preparation of quartenary ammoniumsalts of esomeprazole. Further, the present invention also relates to the use quartenary ammoniumsalts of esomeprazole for the treatment of gastrointestinal disorders, pharmaceutical compositions containing them as well as the quartenary ammoniumsalts of esomeprazole, as such.

  本发明涉及一种制备左旋埃索美拉唑季铵盐的方法。此外，本发明还涉及使用左旋埃索美拉唑季铵盐治疗胃肠道疾病，含有其作为成分的制药组合物以及左旋埃索美拉唑季铵盐本身。
• Heterocyclic substituted triazolyl phosphorous compounds, insecticidal compositions containing them and method for controlling insects
  申请人：THE DOW CHEMICAL COMPANY

  公开号：EP0010891A1

  公开（公告）日：1980-05-14

  Pyridyl, pyridazinyl, pyrimidinyl and pyrazinyl substituted triazolyl phosphorothioates, insecticidal compositions containing them and method for controlling insects. These compounds and compositions are especially effective in controlling German cockroaches, cooling moth, Western spotted cucumber beetle, beet armyworm, tobacco budworm, green peach aphid and two spotted spider mite while having low toxicity to warm-blooded animals.

  吡啶基、哒嗪基、嘧啶基和吡嗪基取代的三唑基硫代磷酸酯、含有它们的杀虫组合物和控制昆虫的方法。这些化合物和组合物对控制德国蟑螂、冷却蛾、西斑黄瓜甲虫、甜菜夜蛾、烟草芽虫、绿桃蚜和双斑蜘蛛螨特别有效，同时对温血动物毒性低。
• Preparation of cyano (6-(substituted phenoxy)-2-pyridinyl) methyl esters of 3-(2,2-dihaloethenyl)-2,2-dimethyl cyclopropane carboxylic acids
  申请人：THE DOW CHEMICAL COMPANY

  公开号：EP0050846A1

  公开（公告）日：1982-05-05

  A process for preparing cyano(6-(substituted phenoxy)-2-pyridinyl)methyl esters of 3-(2,2-dihaloethenyl)-2,2-dimethylcyclopropane carboxylic acids wherein an appropriate 6-(substituted phenoxy)picolinaldehyde is reacted with a 3-(2,2-dihaloethenyl)-2,2-dimethylcyclopropane carboxylic acid halide in the presence of an alkali metal cyanide and a solvent.

  一种制备 3-(2,2-二卤乙烯基)-2,2-二甲基环丙烷羧酸氰基(6-(取代苯氧基)-2-吡啶基)甲基酯的工艺，其中适当的 6-(取代苯氧基)吡啶醛与 3-(2,2-二卤乙烯基)-2,2-二甲基环丙烷羧酸卤化物在碱金属氰化物和溶剂存在下反应。
• Stabilization of alkali polysaccharides
  申请人：THE DOW CHEMICAL COMPANY

  公开号：EP0090271A2

  公开（公告）日：1983-10-05

  Improved basic polysaccharides are prepared by contacting a polysaccharide with a tetravalent onium salt such as tetramethylammonium chloride prior to contacting it with a strong base such as sodium hydroxide. Polysaccharide derivatives having a greater degree and uniformity of substitution are prepared from such improved basic polysaccharides.

  在将多糖与氢氧化钠等强碱接触之前，先将多糖与四价鎓盐（如四甲基氯化铵）接触，从而制备出改良的碱性多糖。 从这种改良的碱性多糖中制备出的多糖衍生物具有更高的取代度和均匀性。