ethyl L-alanylglycinate | 66959-35-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: ethyl L-alanylglycinate
• 英文别名: AG-OEt；N-L-alanyl-glycine ethyl ester；N-L-Alanyl-glycin-aethylester；L-Alanyl=>glycin-aethylester；Ala-Gly-ethylester；Ala-Gly-OEt；l-Alanylglycine ethyl ester；ethyl 2-[[(2S)-2-aminopropanoyl]amino]acetate
• CAS: 66959-35-1
• 化学式: C₇H₁₄N₂O₃
• 分子量: 174.2
• InChiKey: LYLNMMLPOPFZGG-YFKPBYRVSA-N

物化性质

• 熔点：
  55-57 °C
• 沸点：
  309.2±22.0 °C(Predicted)
• 密度：
  1.105±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  81.4
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  ethyl L-alanylglycinate 在 溶剂黄146 作用下， 以 乙醇 为溶剂， 反应 20.0h， 生成 (S)-1,4-diacetyl-3-methylpiperazine-2,5-dione
  参考文献：
  名称：

  Preparation of Chiral Right-Half Models of Antitumor Bistetrahydroisoquinolinequinone Natural Products

  摘要：

  The preparation of chiral right-half model compounds of bistetrahydroisoquinolinequinone natural products having a lactam carbonyl group (-)-1 or an aminonitrile group (+)-2 from (-)-14 was presented. The crucial steps of this synthesis include the N-methylation of compound (-)-12 and ring closure to generate (-)-19a without any epimerization at C-2.(1)

  DOI：

  10.3987/com-18-s(t)88
• 作为产物：
  描述：

  protected dipeptide 在 D-dibenzoyltartrate 作用下， 生成 ethyl L-alanylglycinate
  参考文献：
  名称：

  Losse, Chemische Berichte, 1957, vol. 90, p. 1279,1282

  摘要：

  DOI：

文献信息

• A flow reactor process for the synthesis of peptides utilizing immobilized reagents, scavengers and catch and release protocols
  作者：Ian R. Baxendale、Steven V. Ley、Christopher D. Smith、Geoffrey K. Tranmer

  DOI：10.1039/b612197g

  日期：——

  A general flow process for the multi-step assembly of peptides has been developed and this procedure has been used to successfully construct a series of Boc, Cbz and Fmoc N-protected dipeptides in excellent yields and purities, including an extension of the method to enable the preparation of a tripeptide derivative.

  已经开发出一种用于多步骤肽组装的一般流程，该程序已成功用于构建一系列高收率和高纯度的Boc、Cbz和Fmoc N-保护的二肽，包括将该方法扩展至制备三肽衍生物。
• [EN] COMPOUNDS FOR DELIVERING GLUTATHIONE TO A TARGET AND METHODS OF MAKING AND USING THE SAME<br/>[FR] COMPOSÉS POUR L'ADMINISTRATION DE GLUTATHION À UNE CIBLE ET PROCÉDÉS POUR LES PRÉPARER ET LES UTILISER
  申请人：UNIV OREGON STATE

  公开号：WO2017214297A1

  公开（公告）日：2017-12-14

  Disclosed herein are embodiments of compounds that can be used to target glutathione to various target sites, such as cells, mitochondria, and other organelles. Also disclosed herein are embodiments of methods for making and using the compounds. In particular disclosed embodiments, the compounds can be used to treat, ameliorate, and/or prevent diseases or conditions associated with low or reduced glutathione levels, as well as other types of diseases/conditions.

  本文披露了可以用于靶向谷胱甘肽到各种目标位点的化合物实施例，例如细胞、线粒体和其他细胞器。本文还披露了制备和使用这些化合物的方法的实施例。特别披露的实施例中，这些化合物可用于治疗、改善和/或预防与低谷胱甘肽水平或减少有关的疾病或症状，以及其他类型的疾病/症状。
• Simplifying alternating peptide synthesis by protease-catalyzed dipeptide oligomerization
  作者：Xu Qin、Anne C. Khuong、Zheng Yu、Wenzhe Du、John Decatur、Richard A. Gross

  DOI：10.1039/c2cc36381j

  日期：——

  A unique route to perfectly alternating oligopeptides is described. First, AG-OEt was prepared by standard chemical coupling. Then, AG-OEt was converted by papain-catalysis in 30 s to (AG)x (80%-yield, x = 9.4 ± 0.3). Extension of this strategy to other alternating peptide compositions as well as the importance of selecting a protease and reaction conditions that avoid competing transamidation and hydrolysis reactions is discussed.

  描述了完美交替寡肽的独特途径。首先，通过标准化学偶联制备AG-OEt。然后，AG-OEt 通过木瓜蛋白酶催化在 30 秒内转化为 (AG)x（80% 产率，x = 9.4 ± 0.3）。讨论了将该策略扩展到其他交替肽组合物以及选择蛋白酶和避免竞争性转酰胺基和水解反应的反应条件的重要性。
• Synthesis of Chiral 2,4-Chiral 2,4-Dichloro-6-menthoxy-1,3,5-triazines and 2-Chloro-4, 6-Dimenthoxy-1,3,5-triazines as Enantiodifferentiating Coupling Reagents. An X-ray Study on 2,4,6-Trimenthoxy-1,3,5-triazine
  作者：Zbigniew J. Kamiński、Stanislaw W. Markowicz、Beata Kolesińska、Dariusz Martynowski、Marek L. Główka

  DOI：10.1080/00397919808004839

  日期：1998.7

  Abstract Chiral mono-di-and trimenthoxy-1,3,5-triazines ware obtained from natural menthol and cyanuric chloride and applied as enantioselective coupling reagents in the synthesis of dipeptides.

  摘要 以天然薄荷醇和氰尿酰氯为原料制备的手性单二和三薄荷氧基1,3,5-三嗪类化合物，在二肽合成中用作对映选择性偶联剂。
• Grassmann; Wuensch, Chemische Berichte, 1958, vol. 91, p. 449,453
  作者：Grassmann、Wuensch

  DOI：——

  日期：——