2,4-Dihydrazino-6-methyl-pyrimidin | 1980-55-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2,4-Dihydrazino-6-methyl-pyrimidin
• 英文别名: (2-Hydrazinyl-6-methylpyrimidin-4-yl)hydrazine
• CAS: 1980-55-8
• 化学式: C₅H₁₀N₆
• mdl: MFCD00499645
• 分子量: 154.175
• InChiKey: HMURPXRHBUNCNW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  102
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2,4-Dihydrazino-6-methyl-pyrimidin 以28%的产率得到
  参考文献：
  名称：

  BROWN D. J.; NAGAMATSU T., AUSTRAL. J. CHEM., 1979, 32, NO 7, 1585-1593

  摘要：

  DOI：
• 作为产物：
  描述：

  6-甲基-2-甲硫基-4-氯嘧啶 在 甲醇 、 一水合肼 作用下， 反应 2.0h， 生成 2,4-Dihydrazino-6-methyl-pyrimidin
  参考文献：
  名称：

  Claesen; Vanderhaeghe, Bulletin des Societes Chimiques Belges, 1959, vol. 68, p. 30,55

  摘要：

  DOI：

文献信息

• Nitroalkanes as electrophiles: synthesis of triazole-fused heterocycles with neuroblastoma differentiation activity
  作者：Nicolai A. Aksenov、Alexander V. Aksenov、Nikita K. Kirilov、Nikolai A. Arutiunov、Dmitrii A. Aksenov、Vladimir Maslivetc、Zhenze Zhao、Liqin Du、Michael Rubin、Alexander Kornienko

  DOI：10.1039/d0ob01007c

  日期：——

  2-hydrazinylquinolines, 2-hydrazinylpyridines and bis-2,4-dihydrazinylpyrimidines in polyphosphoric acid (PPA) affording 1,2,4-triazolo[4,3-a]quinolines, 1,2,4-triazolo[4,3-a]pyridines and bis[1,2,4]triazolo[4,3-a:4′,3′-c]pyrimidines, respectively. The reaction expands the scope of heterocyclic annulations involving phosphorylated nitronates, believed to be the electrophilic intermediates formed from nitroalkanes

  我们发现了硝基烷烃与 2-肼基喹啉、2-肼基吡啶和双 2,4-二肼基嘧啶在多磷酸 (PPA) 中的反应，得到 1,2,4-三唑并[4,3- a ]喹啉, 1,2,4 -三唑并[4,3- a ]吡啶和双[1,2,4]三唑并[4,3- a :4′,3′- c]嘧啶，分别。该反应扩大了涉及磷酸化硝酸盐的杂环环化的范围，被认为是由 PPA 中的硝基烷形成的亲电子中间体。几种合成的三唑类化合物通过诱导神经母细胞瘤癌细胞分化而显示出有希望的抗癌活性。由于迫切需要用于神经母细胞瘤治疗的新型分化剂，这一发现值得进一步评估这类化合物对神经母细胞瘤的治疗作用。
• Andrisano, Bollettino Scientifico della Facolta di Chimica Industriale di Bologna, 1944, vol. 5, p. 48,51
  作者：Andrisano

  DOI：——

  日期：——
• Spin crossover complex [](ClO4)2·H2O (L1 = 4-methyl-2,6-bis(1H-pyrazol-1-yl)pyrimidine): Synthesis and properties
  作者：Mark B. Bushuev、Viktor P. Krivopalov、Elena B. Nikolaenkova、Vasiliy A. Daletsky、Gleb A. Berezovskii、Lilia A. Sheludyakova、Vladimir A. Varnek

  DOI：10.1016/j.poly.2012.05.039

  日期：2012.8

  The complex [FeL21](ClO4)(2)center dot H2O (1a) (L-1 = 4-methyl-2,6-bis(1H-pyrazol-1-yl)pyrimidine) was synthesized by the reaction of Fe(ClO4)(2)center dot 6H(2)O with new NNN-tridentate pyrazolylpyrimidine ligand L-1 in MeOH/EtOH mixture. It is the first example of iron(II) spin crossover complexes with 2,4(6)-di(1H-pyrazol-1-yl)pyrimidines and manifests gradual spin transition centered around 150 K on the chi T-M versus T curve without hysteresis. A broad heat capacity anomaly with the maximum at 150 K was observed on the C-p(T) dependence, Delta H-trs = 5.50 kJ/mol and Delta S-trs = 42.0 J/(mol K). Surprisingly, the syntheses of iron(II) perchlorate compound with L-1 performed in EtOH and iPrOH afford another modification of the complex, [FeL21](ClO4)(2)center dot H2O (1b), being high spin in the 78-300 K temperature range. The complexes with 2,4-bis(3,5-dimethyl-1H-pyrazol-1-yl)-6-methylpyrimidine (L-2). [FeL22](ClO4)(2)center dot EtOH (2), [FeL22](CF3SO3)(2) (3), [(FeLCl2)-Cl-2] 0.5H(2)O (9) and [FeL2(NCS)(2)] (5) were synthesized in EtOH solutions. They are in the high spin state within 78-300 K temperature range. (C) 2012 Elsevier Ltd. All rights reserved.
• CRISTEA, IOAN;FARCASAN, VALER, STUD. UNIV. BABES-BOLYAI. CHEM., 34,(1989) N, C. 60-63
  作者：CRISTEA, IOAN、FARCASAN, VALER

  DOI：——

  日期：——
• Claesen; Vanderhaeghe, Bulletin des Societes Chimiques Belges, 1959, vol. 68, p. 30,55
  作者：Claesen、Vanderhaeghe

  DOI：——

  日期：——