(2,4-dichlorophenyl)(4-nitrophenyl)methanone | 855194-85-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2,4-dichlorophenyl)(4-nitrophenyl)methanone
• 英文别名: 2,4-dichloro-4'-nitro-benzophenone；2,4-Dichlor-4'-nitro-benzophenon；(2,4-Dichlorophenyl)-(4-nitrophenyl)methanone
• CAS: 855194-85-3
• 化学式: C₁₃H₇Cl₂NO₃
• 分子量: 296.109
• InChiKey: IUFJCMLSLLLXNB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  62.9
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (2,4-dichlorophenyl)(4-nitrophenyl)methanone 在 甲醇 、 镍 作用下， 100.0 ℃ 、7.84 MPa 条件下， 生成 4'-amino-2,4-dichloro-benzophenone
  参考文献：
  名称：

  魁北克一世练习曲

  摘要：

  Dans ce在étudie上的旅行：

  DOI：

  10.1002/hlca.19520350718
• 作为产物：
  描述：

  2,4-二氯苯乙酸乙酯 、 硝基苯 在 potassium tert-butylate 作用下， 以 苯 为溶剂， 以68%的产率得到(2,4-dichlorophenyl)(4-nitrophenyl)methanone
  参考文献：
  名称：

  Transition-Metal-Free Regiospecific Aroylation of Nitroarenes Using Ethyl Arylacetates at Room Temperature

  摘要：

  A novel regiospecific C(sp(3))-C(sp(2)) coupling between ethyl arylacetates and nitroarenes has been developed to deliver biaryl ketones in excellent yields. The protocol is metal-free, mild, and compatible with a number of functional groups on both of the reacting partners.

  DOI：

  10.1021/acs.orglett.7b03882

文献信息

• Method for acylation or sulphonylation of an aromatic compound
  申请人：Rhodia Chimie

  公开号：US06348631B1

  公开（公告）日：2002-02-19

  The present invention relates to a process for the acylation or sulphonylation of an aromatic compound. More particularly, the invention relates to a process for the acylation or sulphonylation of an activated or deactivated aromatic compound. The invention is applied to the preparation of aromatic ketones or sulphones. The process for the acylation or sulphonylation of an aromatic compound which consists in reacting at least one aromatic compound with an acylating or sulphonylating agent, in the presence of a Friedel-Crafts catalyst is characterized in that the acylation or sulphonylation reaction is carried out in liquid phase under microwave irradiation.

  本发明涉及一种芳香化合物的酰化或磺化过程。 更具体地，该发明涉及一种对活化或去活化的芳香化合物进行酰化或磺化的过程。 该发明应用于芳香酮或磺酮的制备。 将至少一种芳香化合物与酰化剂或磺化剂在弗里德尔-克拉夫茨催化剂存在下反应的芳香化合物酰化或磺化过程的特征在于，在微波辐射下在液相中进行酰化或磺化反应。
• Synthesis, structure, and characterization of picolyl‐ and benzyl‐linked biphenyl palladium N‐heterocyclic carbene complexes and their catalytic activity in acylative cross‐coupling reactions
  作者：Nalluchamy Muniyappan、Shahulhameed Sabiah

  DOI：10.1002/aoc.5421

  日期：2020.4

  N‐heterocyclic carbene ligands with picolyl (L1H2Br2, L3H2Br2) and benzyl (L2H2Br2, L4H2Br2) linked biphenyl backbone were synthesized and characterized. Their palladium(II) complexes [PdL1]Br2 (1), [PdL2Br2] (2), [PdL3]Br2 (3), and [PdL4Br2] (4) were synthesized by direct method using Pd(OAc)2. All complexes (1–4) were characterized by CHN analysis, electrospray ionization‐MS, nuclear magnetic resonance

  合成并表征了具有吡啶基（L 1 H 2 Br 2，L 3 H 2 Br 2）和苄基（L 2 H 2 Br 2，L 4 H 2 Br 2）连接的联苯基骨架的N杂环卡宾配体。他们的钯（II）配合物[PdL 1 ] Br 2（1），[PdL 2 Br 2 ]（2），[PdL 3 ] Br 2（3）和[PdL 4 Br 2 ]（4）通过直接方法使用Pd（OAc）2合成。所有复合物（1 - 4）通过CHN分析，电喷雾电离质谱，核磁共振，和单晶X射线衍射进行了表征。分子结构证实了Pd（II）中心周围扭曲的方形平面几何形状。它们均在苯基硼酸与苯甲酰氯的酰基Suzuki交叉偶联中显示出良好的催化活性，从而以良好的收率得到二苯甲酮。
• Research on the Synthesis of Aromatic Hydrazone in Ionic Liquids
  作者：Haibin Wang、Li Sun、Xiaonian Li、Jiangli Duan、Wen Pei

  DOI：10.1080/00397911.2010.517612

  日期：2011.11.1

  Aromatic hydrazones are important intermediates for pesticides cibenzoline and cefxime. The methodology of synthesis of aromatic hydrazone from aromatic ketone and hydrazine hydrate in ionic liquid, was described and various aromatic hydrazones were prepared by the reaction of aromatic ketone with hydrazine hydrate in ionic 1iquid at 100 degrees C with good yields. The ionic liquids could be recycled and reused after the reaction. The influences of the various ionic liquids on the reaction are discussed. The product structure was characterized by infrared, mass spectrometry, NMR spectra, and elemental analysis.