2-羟基-3,5-二碘苯腈 | 2314-30-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-羟基-3,5-二碘苯腈
• 英文名称: 2-hydroxy-3,5-diiodobenzonitrile
• 英文别名: 3,5-diiodo-2-hydroxybenzonitrile；ioxynil；2-hydroxy-3,5-diiodo-benzonitrile；2-Hydroxy-3,5-dijod-benzonitril；2-Cyano-4,6-diiodphenol；Benzonitrile, 2-hydroxy-3,5-diiodo-
• CAS: 2314-30-9
• 化学式: C₇H₃I₂NO
• 分子量: 370.916
• InChiKey: FNNNLVLLTDINFG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  44
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2926909090

反应信息

• 作为反应物：
  描述：

  2-羟基-3,5-二碘苯腈 在 N-甲基吗啉 作用下， 反应 5.0h， 以92%的产率得到2-羟基-5-碘-苯甲腈
  参考文献：
  名称：

  Nonreductive Deiodination of ortho-Iodo-Hydroxylated Arenes Using Tertiary Amines

  摘要：

  [GRAPHIC]A convenient and nonreductive deiodination is reported for the ortho-iodo-hydroxylated arenes inch, ding derivatives of quinolinol, phenol, and naphthol. Tertiary amines pyridine, triethylamine, and N-methylmorpholine in the presence of water initiated deiodination of ortho-iodo-hydroxylated arenes without affecting para-iodine and other reduction-susceptible groups. This reported method also works efficiently for polyiodinated systems. Simplicity, short reaction times, and absence of reducing catalyst are features of this method.

  DOI：

  10.1021/jo051191x
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 生成 2-羟基-3,5-二碘苯腈
  参考文献：
  名称：

  Buu-Hoi et al., Bulletin de la Societe Chimique de France, 1954, p. 294

  摘要：

  DOI：

文献信息

• Regioselective Iodine/Zinc Exchange for the Selective Functionalization of Polyiodinated Arenes and Heterocycles in Toluene
  作者：Florian Sanchez、Alexandre Desaintjean、Paul Knochel、Fanny Danton

  DOI：10.1055/a-1559-3384

  日期：2021.12

  Regioselective I/Zn-exchange reactions were performed on polyiodinated arenes or heterocycles within 20 minutes at 0–25 °C using the bimetallic combination pTol2Zn·2LiOR [R = (CH2)2N(Me)(CH2)2NMe2] in toluene. The resulting diaryl- or diheteroarylzincs reacted well with allylic bromides and acyl chlorides to provide functionalized (hetero)aryl iodides in good yields.

  使用双金属组合 pTol2Zn·2LiOR [R = (CH2)2N(Me)(CH2)2NMe2] 在甲苯中，在 20 分钟内在 0–25 °C 下对多碘化芳烃或杂环进行区域选择性 I/Zn 交换反应。所得二芳基-或二杂芳基锌与烯丙基溴和酰氯反应良好，以良好的产率提供官能化的（杂）芳基碘化物。
• Directed Ortho Insertion (DoI):  A New Approach to Functionalized Aryl and Heteroaryl Zinc Reagents
  作者：Nadège Boudet、Shohei Sase、Pradipta Sinha、Ching-Yuan Liu、Arkady Krasovskiy、Paul Knochel

  DOI：10.1021/ja074060h

  日期：2007.10.1

  A wide range of directing groups (ester, ketone, acetate, aryl sulfonate, triazene, carbamate) allow the regioselective directed ortho insertion (DoI) of zinc in the presence of LiCl leading to polyfunctional aryl and heteroaryl zinc reagents.

  范围广泛的导向基团（酯、酮、乙酸酯、芳基磺酸盐、三氮烯、氨基甲酸酯）允许在 LiCl 存在下区域选择性定向邻位插入（DoI）锌，从而产生多官能的芳基和杂芳基锌试剂。
• Microencapsulated agriculturally active material
  申请人：GRIFFIN CORPORATION

  公开号：EP0380325A2

  公开（公告）日：1990-08-01

  Agriculturally active materials, such as pesticides, herbicides and the like and a process for microencapsulating said materials. The present invention includes trifluralin having a polymorphic form characterized by a yellow color and a melting point of approximately 41°-- 43° C. The present invention also includes a method of using the yellow polymorphic form of trifluralin as a herbicide. In addition, the present invention includes a method of microencapsulating low-melting agricurally active materials, such as trifluralin. The microencapsulation process comprises the steps of heating a low-melting, water-immiscible, agricurally active material to a molten state. The molten active material is then combined with an aqueous solution of a water-soluble, film-forming polymer at a temperature sufficient to maintain the active material in its molten state. The active material is then dispersed or emulsified in the aqueous solution so that the active material has a primary particle size of between approximately 0.1 and 10 microns. The resulting dispersion or emulsion is then spray dried at a temperature between approximately 50° and 220° C. so as to microencapsulate the active material in the polymer. Compounds for promoting the rapid solidification of the active material are also disclosed.

  农业活性材料，如杀虫剂、除草剂等，以及微囊化上述材料的工艺。本发明包括具有多晶型的三氟拉林，其特征为黄色，熔点约为 41°-43° C，本发明还包括将黄色多晶型的三氟拉林用作除草剂的方法。此外，本发明还包括一种微胶囊化低熔点农业活性物质（如三氟脲）的方法。微胶囊化工艺包括以下步骤：将低熔点、不溶于水的农用活性材料加热至熔融状态。然后，在足以使活性物质保持熔融状态的温度下，将熔融活性物质与水溶性成膜聚合物的水溶液混合。然后将活性材料分散或乳化在水溶液中，使活性材料的主要粒径在 0.1 至 10 微米之间。然后在约 50° 至 220° C 的温度下喷雾干燥所得到的分散体或乳液，以便将活性材料微囊化在聚合物中。此外，还公开了促进活性材料快速凝固的化合物。
• Herbicidal compositions
  申请人：Bayer CropScience S.A.

  公开号：EP1346638A1

  公开（公告）日：2003-09-24

  This invention provides a method for controlling the growth of weeds (i.e. undesired vegetation) at a locus which comprises applying to the locus a herbicidally effective amount of: (a) a phenoxypicolinamide derivative of formula I; and (b) a urea herbicide.

  本发明提供了一种控制杂草（即不受欢迎的植被）生长的方法，该方法包括在某一地点施用除草剂有效量的下列物质： (a) 式 I 的苯氧基吡啶脲衍生物 (b) 尿素除草剂。
• Piperidine-mediated annulation of 2-acylphenols with 4-nitrobenzaldehyde to 3-benzofuranones
  作者：Nishant Verma、Varun Kundi、Naseem Ahmed

  DOI：10.1016/j.tetlet.2015.05.023

  日期：2015.7

  Piperidine mediated reactions of 2-acylphenols and 4-nitrobenzaldehydes afforded 3-benzofuranones in high yield (82-95%) at reflux temperature in ethanol. The electron density calculation of HOMO-LUMO energy in the chalcone intermediates by DFT showed the influence of the 4-nitro group and alkyl chain at C-2 position for the regioselective products. However, the reaction of 2- and 3-nitrobenzaldehydes with 2-acylphenols afforded flavones and flavanones, respectively, under the same reaction conditions. The substituent position effects were further studied in respect of 2-, 3- and 4-nitro substituted benzaldehydes and 2-acylphenols in the product formation. (C) 2015 Elsevier Ltd. All rights reserved.