1-methyl-piperidine-2,6-dicarboxylic acid diethyl ester | 182950-23-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1-methyl-piperidine-2,6-dicarboxylic acid diethyl ester
• 英文别名: 1-Methyl-piperidin-2,6-dicarbonsaeure-diaethylester；Diethyl 1-methylpiperidine-2,6-dicarboxylate
• CAS: 182950-23-8
• 化学式: C₁₂H₂₁NO₄
• 分子量: 243.303
• InChiKey: JWXBWRHECKWURL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  55.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  1-methyl-piperidine-2,6-dicarboxylic acid diethyl ester 、 二乙氨基乙醇 在 sodium 2-(diethylamino)ethanolate 作用下， 生成 1-methyl-piperidine-2,6-dicarboxylic acid bis-(2-diethylamino-ethyl ester)
  参考文献：
  名称：

  Rubzow et al., Zhurnal Obshchei Khimii, 1956, vol. 26, p. 130,132; engl. Ausg. S. 129, 131

  摘要：

  DOI：
• 作为产物：
  描述：

  2,6-吡啶二羧酸二乙酯 在 盐酸 、 乙醇 、 铂 、 碘甲烷 作用下， 生成 1-methyl-piperidine-2,6-dicarboxylic acid diethyl ester
  参考文献：
  名称：

  Rubzow et al., Zhurnal Obshchei Khimii, 1956, vol. 26, p. 130,132; engl. Ausg. S. 129, 131

  摘要：

  DOI：

文献信息

• [EN] NOVEL 3,8-DIAZA-BICYCLO[3.2.1]OCTANE- AND 3,9-DIAZA-BICYCLO[3.3.1]-NONANE-3-CARBOXYLIC ACID ESTER DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS<br/>[FR] NOUVEAUX DÉRIVÉS D'ESTER 3,8-DIAZA-BICYCLO[3.2.1]OCTANE- AND 3,9-DIAZA-BICYCLO[3.3.1]-NONANE-3-ACIDE CARBOXYLIQUE ET LEUR UTILISATION EN TANT QU'INHIBITEURS DE LA RECAPTURE DU NEUROTRANSMETTEUR MONOAMINES
  申请人：NEUROSEARCH AS

  公开号：WO2009109517A1

  公开（公告）日：2009-09-11

  This invention relates to novel 3,8-diaza-bicyclo[3.2.1]octane-and 3,9-diaza- bicyclo[3.3.1]nonane-3-carboxylic acid ester derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention. Formula (I).

  这项发明涉及作为单胺神经递质再摄取抑制剂有用的新型3,8-二氮杂双环[3.2.1]辛烷和3,9-二氮杂双环[3.3.1]壬烷-3-羧酸酯衍生物。在其他方面，该发明涉及将这些化合物用于治疗方法以及包括该发明化合物的药物组合物。公式（I）。
• Diazabicyclic Aryl Derivatives and Their Use as Chinolinergic Ligands at the Nicotinic Acetylcholine Receptors
  申请人：Peters Dan

  公开号：US20080146582A1

  公开（公告）日：2008-06-19

  This invention relates to novel diazabicyclic aryl derivatives which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

  本发明涉及一种新型的二氮杂双环芳基衍生物，这些衍生物被发现是乙酰胆碱受体的胆碱能配体，以及单胺类受体和转运体的调节剂。由于它们的药理特性，本发明的化合物可能对治疗与中枢神经系统（CNS）和周围神经系统（PNS）的胆碱能系统相关的疾病或障碍、平滑肌收缩相关的疾病或障碍、内分泌疾病或障碍、神经退行性疾病或障碍、炎症相关的疾病或障碍、疼痛以及因滥用化学物质而引起的戒断症状可能有用。
• Novel Diazabicycylic Aryl Derivatives and Their Medical Use
  申请人：Peters Dan

  公开号：US20080280912A1

  公开（公告）日：2008-11-13

  This invention relates to novel diazabicyclic aryl derivatives, which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

  本发明涉及一种新颖的二氮杂双环芳基衍生物，其被发现是尼古丁乙酰胆碱受体的胆碱能配体，并且是单胺类受体和转运体的调节剂。由于它们的药理特性，本发明的化合物可能对与中枢神经系统（CNS）和周围神经系统（PNS）的胆碱能系统相关的疾病或障碍，与平滑肌收缩相关的疾病或障碍，内分泌疾病或障碍，与神经退行性疾病相关的疾病或障碍，与炎症、疼痛以及由于滥用化学物质而导致的戒断症状相关的疾病或障碍的治疗可能有用。
• NOVEL 3,8-DIAZA-BICYCLO[3.2.1]OCTANE-AND 3,9-DIAZA-BICYCLO[3.3.1]-NONANE-3-CARBOXYLIC ACID ESTER DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS
  申请人：Peters Dan

  公开号：US20110092487A1

  公开（公告）日：2011-04-21

  This invention relates to novel 3,8-diaza-bicyclo[3.2.1]octane-and 3,9-diaza-bicyclo[3.3.1]nonane-3-carboxylic acid ester derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention. Formula (I).

  本发明涉及新型3,8-二氮杂双环[3.2.1]辛烷和3,9-二氮杂双环[3.3.1]壬烷-3-羧酸酯衍生物，其可用作单胺神经递质再摄取抑制剂。在其他方面，本发明涉及使用这些化合物的治疗方法以及包含本发明化合物的制药组合物。式（I）。
• INDOLYL-PYRIDAZINYL-DIAZABICYCLONONANE DERIVATIVES IN LABELLED AND UNLABELLED FORM AND THEIR USE IN DIAGNOSTIC METHODS
  申请人：Peters Dan

  公开号：US20110142758A1

  公开（公告）日：2011-06-16

  The present invention relates to indolyl-pyhdazinyl-diazabicyclononane derivatives in their labelled and unlabelled form. Furthermore, the present invention relates to the use of said derivatives in their labelled or unlabelled form in diagnostic methods, in particular for in vivo receptor imaging (neuroimaging).

  本发明涉及标记和未标记的吲哚基吡嗪基二氮杂双环壬烷衍生物。此外，本发明涉及所述衍生物在其标记或未标记形式中在诊断方法中的使用，特别是用于体内受体成像（神经成像）。