N-(2-苯基乙基)-3-戊胺 | 71797-47-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N-(2-苯基乙基)-3-戊胺
• 英文名称: (1-Ethylpropyl)(2-phenylethyl)amine
• 英文别名: N-(2-phenylethyl)pentan-3-amine
• CAS: 71797-47-2
• 化学式: C₁₃H₂₁N
• mdl: MFCD08691720
• 分子量: 191.316
• InChiKey: ODDCELUOAPMLAA-UHFFFAOYSA-N

物化性质

• 沸点：
  272.7±9.0 °C(Predicted)
• 密度：
  0.894±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.538
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  Pentan-3-ylidene(2-phenylethyl)amine 在 bis(η5-cyclopentadinyl)dihydridomolybdenum 对甲苯磺酸 、 溶剂黄146 作用下， 以 甲苯 为溶剂， 反应 92.0h， 生成 N-(2-苯基乙基)-3-戊胺
  参考文献：
  名称：

  Reductions of CO and CN groups with the systems composed of (η5-C5H5)2MoH2 and acids

  摘要：

  Selective reductions of organic compounds, such as carbonyl compounds and imines, using a system composed of Cp2MoH2 and acids are examined. This system can reduce the substrates under mild conditions. Extremely high diastereoselectivity was achieved in the reduction of 4-t-butylcyclohexanone. The reactivity of imines depends on their structure. Aromatic imines are found to be more reactive than aliphatic imines. (C) 1998 Elsevier Science S.A. All rights reserved.

  DOI：

  10.1016/s0022-328x(98)00782-7

文献信息

• Preparation of secondary amines by reductive amination with metallic magnesium
  作者：Ivan V. Mićović、M. D. Ivanović、Goran M. Roglić、Vesna D. Kiricojević、Jelena B. Popović

  DOI：10.1039/p19960000265

  日期：——

  A novel and efficient method for the preparation of secondary amines by reductive amination of carbonyl compounds with primary amines has been developed. The reduction, effected with metallic magnesium in methanol, utilizing triethylamine–acetic acid as a buffer, gave pure secondary amines, mostly in good yields (65–80%). No formation of tertiary amines or alcohols was observed. Use of ammonium acetate

  已经开发了通过用伯胺还原胺化羰基化合物来制备仲胺的新颖而有效的方法。还原反应是利用三乙胺-乙酸作为缓冲液，用甲醇中的金属镁完成的，得到的纯仲胺大部分收率很高（65-80％）。没有观察到叔胺或醇的形成。使用乙酸铵作为氨基组分以适度的产率（约50％）得到伯胺，以及可变量的仲胺。烯胺未经历还原。该方法便宜，相对快速，操作简单并且适用于大规模制备。另外，已经开发了一种从仲胺中分离伯胺的简单方法。
• Structure–activity relationships of small molecule inhibitors of RAGE-Aβ binding
  作者：Nathan T. Ross、Rashid Deane、Sheldon Perry、Benjamin L. Miller

  DOI：10.1016/j.tet.2013.05.079

  日期：2013.9

  The Receptor for Advanced Glycation Endproducts ('RAGE') mediates transport of amyloid-beta peptide (A beta) into the brain, and is therefore an important target for the development of therapeutic agents for Alzheimer's disease. We describe structure activity relationships for inhibition of RAGE-A beta binding, derived from the analysis of a library of tertiary amides. (C) 2013 Elsevier Ltd. All rights reserved.
• KOZLOV N. S.; GLADKIX L. V.; KOZINTSEV S. I.; EFIMOVA T. K., DOKLADY AN BSSR, 1979, 23, HO 8, 713-715
  作者：KOZLOV N. S.、 GLADKIX L. V.、 KOZINTSEV S. I.、 EFIMOVA T. K.

  DOI：——

  日期：——
• US9758477B2
  申请人：——

  公开号：US9758477B2

  公开（公告）日：2017-09-12