diphenylmethyl hydroperoxide | 20614-54-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: diphenylmethyl hydroperoxide
• 英文别名: Diphenylmethaneperoxol；[hydroperoxy(phenyl)methyl]benzene
• CAS: 20614-54-4
• 化学式: C₁₃H₁₂O₂
• 分子量: 200.237
• InChiKey: QFISYKBJJWTOOD-UHFFFAOYSA-N

物化性质

• 熔点：
  50-52 °C
• 沸点：
  361.6±31.0 °C(Predicted)
• 密度：
  1.154±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  diphenylmethyl hydroperoxide 在 锌 作用下， 以 二氯甲烷 、 溶剂黄146 为溶剂， 反应 18.0h， 生成 (1S,2R)-1,2-diphenylethane-1,2-diol
  参考文献：
  名称：

  醇类的光化学反应-II：芳族醇的辐照

  摘要：

  芳香醇的紫外线照射导致形成多种产物：羰基化合物，醚，α-乙二醇和四-芳基-1,4-二恶烷。

  DOI：

  10.1016/0040-4020(82)85088-6
• 作为产物：
  描述：

  二苯基甲烷 在 Cr₂O₄^(2-)*Cu⁽²⁺⁾ 、 双氧水 作用下， 以 乙腈 为溶剂， 生成 diphenylmethyl hydroperoxide
  参考文献：
  名称：

  CuCr 2 O 4尖晶石纳米粒子的制备：通过激活C sp3- H键选择性氧化环烷烃的潜在催化剂

  摘要：

  我们在这里报告了由水热途径中的阳离子表面活性剂CTAB介导的CuCr 2 O 4尖晶石纳米颗粒催化剂的制备。X射线衍射显示形成了CuCr 2 O 4尖晶石相，而透射电镜显示其粒径为30-60 nm。推测该催化剂对于用H 2 O 2将环己烷选择性氧化为环己酮具有高活性。在50℃的温度下，在该催化剂上实现了70％的环己烷转化率和85％的环己酮选择性。而且，即使再使用8次，该催化剂也没有表现出任何明显的活性损失，并证明了其在氧化其他环烷烃中的功效。

  DOI：

  10.1016/j.catcom.2014.10.015

文献信息

• The PANDAS Subgroup: Recognition and Treatment
  作者：Susan E. Swedo、Marjorie Garvey、Lisa Snider、Charlotte Hamilton、Henrietta L. Leonard

  DOI：10.1017/s1092852900021799

  日期：2001.11

  A subgroup of patients with childhood-onset obsessive-compulsive disorder (OCD) has been identified who share a common clinical course characterized by dramatic symptom exacerbations following Group A beta-hemolytic streptococcal (GABHS) infections. The term PANDAS has been applied to the subgroup, to indicate the postulated etiology of their symptoms: Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infections. Five clinical characteristics define the PANDAS subgroup: presence of OCD and/or tic disorder, prepubertal symptom onset, sudden onset or abrupt exacerbations (sawtooth course), association with neurological abnormalities (presence of adventitious movements or motoric hyperactivity during exacerbations), and temporal association between symptom exacerbations and GABHS infections. Post-streptococcal symptom exacerbations are typically quite dramatic, with patients reporting that their symptoms “…came on overnight” or “…appeared all of a sudden a few days after I had a sore throat.” The post-streptococcal inflammatory nature of the neuropsychiatric symptoms provides novel opportunities for treatment and prevention, including immunomodulatory therapies such as therapeutic plasma exchange (TPE) and intravenous immunoglobulin (IVIG). A recently completed placebo-controlled trial revealed that both IVIG and TPE were effective in reducing neuropsychiatric symptom severity (40% to 55% reductions, respectively) for a group of severely ill children with OCD and/or tic disorders. Further research is required to determine why the treatments are helpful, as well as to ascertain whether or not antibiotic prophylaxis can help prevent post-streptococcal symptom exacerbations.

  摘要 在儿童期发病的强迫症（OCD）患者中发现了一个亚群，他们具有共同的临床病程，其特点是在感染 A 组β-溶血性链球菌（GABHS）后症状急剧加重。PANDAS 一词已用于该亚群，以表明其症状的假定病因：与链球菌感染相关的小儿自身免疫性神经精神障碍。PANDAS 亚组有五个临床特征：存在强迫症和/或抽搐症、青春期前发病、突然发病或突然加重（锯齿状病程）、与神经系统异常有关（加重时出现临近运动或运动亢进）以及症状加重与 GABHS 感染在时间上有关。链球菌感染后的症状加重通常相当剧烈，患者会说他们的症状"......一夜之间就出现了 "或"......在我喉咙痛几天后突然出现"。链球菌感染后神经精神症状的炎症性质为治疗和预防提供了新的机会，包括治疗性血浆置换（TPE）和静脉注射免疫球蛋白（IVIG）等免疫调节疗法。最近完成的一项安慰剂对照试验显示，对于一组患有强迫症和/或抽搐症的重症儿童，静脉注射免疫球蛋白和治疗性血浆置换疗法都能有效减轻神经精神症状的严重程度（分别减轻 40% 至 55%）。还需要进一步的研究来确定为什么这些治疗方法有帮助，以及抗生素预防是否有助于预防链球菌感染后症状加重。
• Indium-Mediated Synthesis of Benzylic Hydroperoxides
  作者：Yuxuan Hou、Jinjin Hu、Ruigang Xu、Shulei Pan、Xiaofei Zeng、Guofu Zhong

  DOI：10.1021/acs.orglett.9b01070

  日期：2019.6.21

  An indium(0)-metal-mediated efficient synthesis of benzylic hydroperoxides is described. The reaction proceeds efficiently with a broad range of benzyl bromides under aerobic conditions at room temperature to afford benzyl hydroperoxides in good to excellent yields. In addition, the tandem hydroperoxidation-Michael addition of (E)-1-(bromomethyl)-2-(2-nitrovinyl)benzene was also demonstrated.

  描述了铟（0）-金属介导的苄基氢过氧化物的有效合成。在室温下，在有氧条件下，反应可与多种苄基溴有效地进行，从而以良好或优异的收率得到氢过氧化苄基。另外，还证实了串联的（E）-1-（溴甲基）-2-（2-硝基乙烯基）苯的加氢过氧化-迈克尔加成。
• Enantioselective Peroxidation of <i>C</i>-alkynyl imines enabled by chiral BINOL calcium phosphate
  作者：Zhongwen Sun、Lijun Chen、Kaixiong Qiu、Bo Liu、Hongtao Li、Fang Yu

  DOI：10.1039/d1cc07156d

  日期：——

  Herein, we report a catalytic enantioselective addition of C-alkynyl imines with hydroperoxides catalyzed by chiral BINOL calcium phosphate, affording a broad range of enantioenriched α-peroxy propargylamines in good yields (80–99%) with high enantioselectivities (up to 94% ee). The protocol is characterized by mild conditions, easy accessibility and good practicability.

  在此，我们报道了由手性 BINOL 磷酸钙催化的C-炔基亚胺与氢过氧化物的催化对映选择性加成，以良好的收率（80-99%）和高对映选择性（高达 94% ee）提供范围广泛的对映富集的 α-过氧炔丙基胺）。该协议具有条件温和、易于获取、实用性强的特点。
• Living cationic polymerization process
  申请人：Polysar Limited

  公开号：US04943616A1

  公开（公告）日：1990-07-24

  A polymerization process is provided for producing a terminally functional polymer which comprises introducing a monomer charge, a Lewis acid and an organic peroxy compound into a suitable reaction vessel and polymerizing the monomer charge at a temperature of from about 0.degree. to about -80.degree. C. to form the terminally functional polymer, wherein the monomer charge comprises isobutylene and the organic peroxy compound is charged in an amount of from about 10.sup.-4 to about 10.sup.-1 moles per mole of the isobutylene. In a preferred embodiment, the monomer charge additionally comprises vinylidene aromatic or diolefin monomers. In another preferred embodiment the monomer charge comprises the sequential addition of isobutylene and vinylidene aromatic or diolefin monomers. In a further preferred embodiment said reaction vessel is additionally charged with an electron door having an electron door number of from about 22 to about 50 the amount of said electron door being from about 10.sup.-4 to about 10.sup.-1 moles of said isobutylene. The invention also provides a novel catalyst system comprising an organic peroxy compund and a Lewis acid for the polymerization of isobutylene or monomer mixtures containing isobutylene.

  提供一种聚合过程，用于生产末端官能团聚合物。该过程包括将单体、路易斯酸和有机过氧化物化合物引入适当的反应容器中，并在约0℃至-80℃的温度下聚合单体，以形成末端官能团聚合物。其中，单体包括异丁烯，有机过氧化物化合物的充电量为每摩尔异丁烯约10^-4至10^-1摩尔。在一种优选实施例中，单体还包括乙烯基芳香族或二烯单体。在另一种优选实施例中，单体包括顺序加入的异丁烯和乙烯基芳香族或二烯单体。在进一步的优选实施例中，所述反应容器还充电有一个电子门，其电子门数为约22至50，所述电子门的量为每摩尔异丁烯约10^-4至10^-1摩尔。该发明还提供了一种新型催化剂体系，包括有机过氧化物化合物和路易斯酸，用于异丁烯或含异丁烯的单体混合物的聚合。
• Fluid, stable interpolymer/polyol compositions, process for the production thereof and processes for the production of elastomeric polyurethanes and polyurethane foams therefrom
  申请人：UNION CARBIDE CORPORATION

  公开号：EP0006605A1

  公开（公告）日：1980-01-09

  Fluid, stable polymer-polyols are provided which consist of an organic polyol medium and an interpolymer of a minor amount of polymerized ethylenically unsaturated dicarboxylic acid anhydride, such as maleic acid anhydride, and a major amount of at least one different polymerized ethylenically unsaturated monomer, the interpolymer being in the form of particles that are stably dispersed in the polyol. Polyurethane foams produced from these polymer/ polyols display improved load bearing and compression set when compared with polymer/polyols produced in a similar manner without the ethylenically unsaturated dicarboxylic acid anhydride: elastomers so produced have improved tensile modulus and tear properties.

  提供了流体稳定聚合物多元醇，它由有机多元醇介质和少量聚合乙烯基不饱和二羧酸酐（如马来酸酐）与大量至少一种不同的聚合乙烯基不饱和单体的互聚物组成，互聚物呈颗粒状稳定地分散在多元醇中。与不含乙烯基不饱和二羧酸酐的聚合物/多元醇相比，用这些聚合物/多元醇生产的聚氨酯泡沫塑料的承载能力和压缩永久变形都有所改善：用这种方法生产的弹性体具有更好的拉伸模量和撕裂性能。