Δ^8,14-cholestene | 54725-42-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: Δ^8,14-cholestene
• 英文别名: 5α-cholest-8(14)-ene；5α-cholestene-(8(14))；5α-Cholesten-(8(14))；5α-Cholest-14(8)-en；5α-Cholest-8(14)-en；Cholest-8(14)-ene, (5alpha)-；(5R,9R,10S,13R,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,5,6,7,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene
• CAS: 54725-42-7
• 化学式: C₂₇H₄₆
• 分子量: 370.662
• InChiKey: LOYUFUGUVLIJNJ-IFNNUIFPSA-N

物化性质

• 熔点：
  53.5-55 °C
• 沸点：
  448.4±12.0 °C(Predicted)
• 密度：
  0.94±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  9.7
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  Δ^8,14-cholestene 在 三氟化硼乙醚 作用下， 生成 12(13<*>14)abeo-5α-cholest-13(17)-ene
  参考文献：
  名称：

  Anastasia,M. et al., Journal of the Chemical Society. Perkin transactions I, 1978, p. 1131 - 1132

  摘要：

  DOI：
• 作为产物：
  描述：

  5α-Cholesta-2,6,8(14)-trien 在 palladium on activated charcoal 氢气 作用下， 生成 Δ^8,14-cholestene
  参考文献：
  名称：

  204.仙人掌固醇，peniocerol（胆甾8-烯-3β，6α-二醇）的结构

  摘要：

  DOI：

  10.1039/jr9650001160

文献信息

• Mass spectrometry in structural and stereochemical problems. Part CCXX. Synthesis and mass spectra of 5α-cholest-8(9)- and 8(14)-en-7-ones
  作者：Ian Midgley、Carl Djerassi

  DOI：10.1039/p19720002771

  日期：——

  spectroscopic evidence, it was shown that these samples are correctly formulated, whereas those reported earlier, by others, are not. Each of these enones undergoes a characteristic reaction in the mass spectrometer, and mechanisms for both diagnostically important processes are suggested.

  5α-Cholest-8（14）-en-7-one（II）的制备方法已知可生产真正的甾体Δ8 （14） -7-酮和Δ8 （9） -7-酮（I从该反应的副产物获得）。根据化学和光谱学证据，表明这些样品配方正确，而其他人先前报告的样品则不正确。这些烯酮中的每一个在质谱仪中都会经历特征性反应，并且提出了对两种诊断重要过程均起作用的机制。
• Peakman, Torren M.; Maxwell, James R., Journal of the Chemical Society. Perkin transactions I, 1988, p. 1065 - 1071
  作者：Peakman, Torren M.、Maxwell, James R.

  DOI：——

  日期：——
• Problems With Null Hypothesis Significance Testing (NHST): What Do the Textbooks Say?
  作者：Jeffrey A. Gliner、Nancy L. Leech、George A. Morgan

  DOI：10.1080/00220970209602058

  日期：2002.1

  The first of 3 objectives in this study was to address the major problem with Null Hypothesis Significance Testing (NHST) and 2 common misconceptions related to NHST that cause confusion for students and researchers. The misconceptions are (a) a smaller p indicates a stronger relationship and (b) statistical significance indicates practical importance. The second objective was to determine how this problem and the misconceptions were treated in 12 recent textbooks used in education research methods and statistics classes. The third objective was to examine how the textbooks' presentations relate to current best practices and how much help they provide for students. The results show that almost all of the textbooks fail to acknowledge that there is controversy surrounding NHST. Most of the textbooks dealt, at least minimally, with the alleged misconceptions of interest, but they provided relatively little help for students.
• The Preparation of ▵⁸-, ▵⁸⁽¹⁴⁾- and ▵¹⁴-Cholestenes¹
  作者：J. C. Eck、E. W. Hollingsworth

  DOI：10.1021/ja01856a035

  日期：1941.11
• Heats of Hydrogenation. I. Apparatus and the Heats of Hydrogenation of Bicyclo-[2,2,1]heptene, Bicyclo[2,2,1]heptadiene, Bicyclo[2,2,2]octene and Bicyclo[2,2,2]octadiene
  作者：Richard B. Turner、W. R. Meador、R. E. Winkler

  DOI：10.1021/ja01572a039

  日期：1957.8