5α-cholesta-8,14-diene | 5226-34-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 5α-cholesta-8,14-diene
• 英文别名: 5α-cholestadiene-(8.14)；5α-Cholestadien-(8.14)；(5R,10S,13R,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,5,6,7,11,12,16,17-decahydro-1H-cyclopenta[a]phenanthrene
• CAS: 5226-34-6
• 化学式: C₂₇H₄₄
• 分子量: 368.646
• InChiKey: YNOMASPNJHCVPH-XONHKMQKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.1
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  5α-cholesta-8,14-diene 、 乙酸乙酯 、 alkaline earth salt of/the/ methylsulfuric acid 生成 Δ^8,14-cholestene
  参考文献：
  名称：

  Problems With Null Hypothesis Significance Testing (NHST): What Do the Textbooks Say?

  摘要：

  The first of 3 objectives in this study was to address the major problem with Null Hypothesis Significance Testing (NHST) and 2 common misconceptions related to NHST that cause confusion for students and researchers. The misconceptions are (a) a smaller p indicates a stronger relationship and (b) statistical significance indicates practical importance. The second objective was to determine how this problem and the misconceptions were treated in 12 recent textbooks used in education research methods and statistics classes. The third objective was to examine how the textbooks' presentations relate to current best practices and how much help they provide for students. The results show that almost all of the textbooks fail to acknowledge that there is controversy surrounding NHST. Most of the textbooks dealt, at least minimally, with the alleged misconceptions of interest, but they provided relatively little help for students.

  DOI：

  10.1080/00220970209602058
• 作为产物：
  描述：

  Δ^8,14-cholestene 在 甲醇 、 乙醚 、 溴 作用下， 生成 5α-cholesta-8,14-diene
  参考文献：
  名称：

  Problems With Null Hypothesis Significance Testing (NHST): What Do the Textbooks Say?

  摘要：

  The first of 3 objectives in this study was to address the major problem with Null Hypothesis Significance Testing (NHST) and 2 common misconceptions related to NHST that cause confusion for students and researchers. The misconceptions are (a) a smaller p indicates a stronger relationship and (b) statistical significance indicates practical importance. The second objective was to determine how this problem and the misconceptions were treated in 12 recent textbooks used in education research methods and statistics classes. The third objective was to examine how the textbooks' presentations relate to current best practices and how much help they provide for students. The results show that almost all of the textbooks fail to acknowledge that there is controversy surrounding NHST. Most of the textbooks dealt, at least minimally, with the alleged misconceptions of interest, but they provided relatively little help for students.

  DOI：

  10.1080/00220970209602058

文献信息

• Acid-Catalysed Backbone Rearrangement of cholesta-6,8(14)-dienes
  作者：Rong-Ming Liu、Xavier F. D. Chillier、Philippe Kamalaprija、Ulrich Burger、Fazil O. Gülaçar

  DOI：10.1002/hlca.19960790407

  日期：1996.6.26

  Rearrangement of 5α- and 5β-cholesta-6,8(14)-dienes (13a and 13b, resp.) in the presence of anhydrous toluene-4-sulfonic acid in acetic acid leads to 5α- and 5β-12(13 14)-abeo-cholesta-8,13(17)-dienes (15a and 15b, resp.) via 5α- and 5β-cholesta-8,14-dienes (14a and 14b, resp.), respectively. Epimerization at C(20) of the spirosteradienes 15a and 15b occurs with increasing reaction time. Molecular-mechanics

  在无水甲苯-4-磺酸存在下，在乙酸中重排5α-和5β-胆甾醇-6,8（14）-二烯（分别为13a和13b）会导致5α-和5β-12（13 14 ） -的abeo- -胆甾-8,13-（17）-dienes（15A和15B，RESP）。通过5α-和5β -胆甾-8,14-二烯（14A和14B，RESP），分别。spirosteradienes 15a和15b在C（20）处的差向异构化随着反应时间的增加而发生。这些化合物及其同类物的相对稳定性的分子力学计算与所观察到的反应路径一致。
• The Preparation of ▵⁸-, ▵⁸⁽¹⁴⁾- and ▵¹⁴-Cholestenes¹
  作者：J. C. Eck、E. W. Hollingsworth

  DOI：10.1021/ja01856a035

  日期：1941.11
• Problems With Null Hypothesis Significance Testing (NHST): What Do the Textbooks Say?
  作者：Jeffrey A. Gliner、Nancy L. Leech、George A. Morgan

  DOI：10.1080/00220970209602058

  日期：2002.1

  The first of 3 objectives in this study was to address the major problem with Null Hypothesis Significance Testing (NHST) and 2 common misconceptions related to NHST that cause confusion for students and researchers. The misconceptions are (a) a smaller p indicates a stronger relationship and (b) statistical significance indicates practical importance. The second objective was to determine how this problem and the misconceptions were treated in 12 recent textbooks used in education research methods and statistics classes. The third objective was to examine how the textbooks' presentations relate to current best practices and how much help they provide for students. The results show that almost all of the textbooks fail to acknowledge that there is controversy surrounding NHST. Most of the textbooks dealt, at least minimally, with the alleged misconceptions of interest, but they provided relatively little help for students.