Nα-acetyl-lysine methyl ester | 687984-51-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Nα-acetyl-lysine methyl ester
• 英文别名: α-acetyllysine methyl ester；Nα-acetyl-Lys-OMe；methyl ester of N-acetyllysine；methyl N-acetyl-lysinate；Methyl 2-acetamido-6-aminohexanoate
• CAS: 687984-51-6
• 化学式: C₉H₁₈N₂O₃
• mdl: MFCD24390334
• 分子量: 202.254
• InChiKey: HHOLXTXLQMKUGJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  14
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.777
• 拓扑面积：
  81.4
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-(naphthalen-1-ylamino)propanoic acid 、 Nα-acetyl-lysine methyl ester 在 1-羟基苯并三唑 、 N,N'-二环己基碳二亚胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以98%的产率得到Methyl 2-acetamido-6-[3-(naphthalen-1-ylamino)propanoylamino]hexanoate
  参考文献：
  名称：

  Fluorescence derivatisation of amino acids in short and long-wavelengths

  摘要：

  3-(Naphthalen-1-ylamino)propanoic acid was coupled to the amino group of the main and lateral chains of various amino acids in order to evaluate its applicability as a fluorescent derivatising reagent. The resulting amino acid derivatives are strongly fluorescent with a maximum emission of about 415 run. Condensation of these derivatives with 5-ethylamino-4-methyl-2-nitrosophenol hydrochloride resulted in the corresponding blue benzo[a]phenoxazinium conjugates, also revealing strong fluorescence in ethanol and water at physiological pH and good quantum yields, but with emission wavelengths between 644 and 657 nm, which was preferable in biological assays. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.03.070
• 作为产物：
  描述：

  methyl 2-acetamido-6-(3-oxoprop-1-enylamino)hexanoate 在 水 作用下， 生成 丙二醛 、 Nα-acetyl-lysine methyl ester
  参考文献：
  名称：

  Degenerative chemistry of malondialdehyde. Structure, stereochemistry, and kinetics of formation of enaminals from reaction with amino acids

  摘要：

  DOI：

  10.1021/ja00401a020

文献信息

• ANTI-ODOR COMPOSITIONS AND THERAPEUTIC USE
  申请人：Yu J. Ruey

  公开号：US20060251597A1

  公开（公告）日：2006-11-09

  This application discloses a composition comprising a malodor compound and an anti-odor ingredient effective for reducing the presence or production of malodor. The composition may be topically applied to a subject and is useful for cosmetic conditions, pharmaceutical indications, or other objectives.

  本申请公开了一种包含恶臭化合物和抑臭成分的组合物，用于减少恶臭的存在或产生。该组合物可以局部应用于一个对象，并且适用于化妆条件、药用指示或其他目的。
• Heat-sensitive compounds exhibitng a cloud point which can be used as extractants for the separation of metals in aqueous solution
  申请人：Commissariat a L'Energie Atomique

  公开号：US07015340B2

  公开（公告）日：2006-03-21

  The invention relates to a heat-sensitive compound having the property of being soluble in water below a critical temperature Tc and insoluble in water above this temperature Tc, this property being thermally reversible, characterized in that it comprises a first amphiphilic and thermally reversible part corresponding to one of the following formulae (I) and (II): in which i is an integer ranging from 1 to 20 and j is an integer ranging from 3 to 30. This compound can be used to extract a chemical entity, such as uranium.

  该发明涉及一种热敏化合物，具有以下性质：在临界温度Tc以下可溶于水，在该温度Tc以上不溶于水，该性质在热上是可逆的，其特征在于它包含第一疏水亲和力和热可逆性部分，对应于以下公式（I）和（II）中的一种：其中i是一个范围从1到20的整数，j是一个范围从3到30的整数。该化合物可用于提取化学实体，如铀。
• POWDERY PREPARATION FOR TRANSMUCOSAL ADMINISTRATION CONTAINING A POLYMERIC FORM OF DRUG AND EXHIBITING IMPROVED STORAGE STABILITY
  申请人：KIRIN BEER KABUSHIKI KAISHA

  公开号：EP1273306A1

  公开（公告）日：2003-01-08

  A powdery preparation for transmucosal administration comprising a medicine of high molecular weight, a cationic polymer and, as needed, a viscous polymer, further comprising an effective amount of a basic amino acid. The powdery preparation for transmucosal administration has an improved storage stability for the medicine of high molecular weight while maintaining an improved mucosal absorption of the medicine.

  一种用于经粘膜给药的粉末状制剂，包含一种高分子量药物、一种阳离子聚合物以及必要时的一种粘性聚合物，还包含有效量的碱性氨基酸。这种经粘膜给药的粉末状制剂可提高高分子量药物的贮存稳定性，同时保持药物更好的粘膜吸收。
• Glycoconjugation processes and compositions
  申请人：PFIZER INC.

  公开号：US10583187B2

  公开（公告）日：2020-03-10

  The invention provides eTEC linked glycoconjugates comprising a saccharide covalently conjugated to a carrier protein through a (2-((2-oxoethyl)thio)ethyl)carbamate (eTEC) spacer, immunogenic compositions comprising such glycoconjugates, and methods for the preparation and use of such glycoconjugates and immunogenic compositions.

  本发明提供了 eTEC 连接糖结合物，包括通过(2-((2-氧代乙基)硫)乙基)氨基甲酸乙酯（eTEC）间隔物与载体蛋白共价连接的糖，包含这种糖结合物的免疫原组合物，以及制备和使用这种糖结合物和免疫原组合物的方法。
• Immunogenic glycoprotein conjugates
  申请人：PFIZER INC.

  公开号：US10668164B2

  公开（公告）日：2020-06-02

  The present invention relates generally to glycoconjugates comprising a saccharide covalently conjugated to a carrier protein through a spacer containing ((2-oxoethyl)thio)). In an aspect the invention provides oxo-eT linked glycoconjugates comprising a saccharide covalently conjugated to a carrier protein through a ((2-oxoethyl)thio) spacer having the formula (I): (I) wherein: A is a group (C═X)m wherein X is S or O and m is 0 or 1; B is a bond, O, or CH2; and when m is 0, B can also be (C═O); R is a C2-C16 alkylene, C2-C16 heteroalkylene, NH—C(═O)—C2-C16 alkylene, or NH—C(═O)—C2-C16 heteroalkylene, wherein said alkylene and heteroalkylene are optionally substituted by 1, 2 or 3 groups independently selected from COOR′ where R′ is selected from H, methyl, ethyl or propyl. The invention further relates to immunogenic compositions comprising such glycoconjugates, and to methods for the preparation and use of such glycoconjugates and immunogenic compositions.

  本发明一般涉及糖共轭物，该糖共轭物包括通过含有((2-氧代乙基)硫)的间隔物与载体蛋白共价连接的糖。）在一个方面，本发明提供了氧化-eT 连接的糖结合物，该糖结合物包含通过含有式（I）的（（2-氧代乙基）硫代）间隔物与载体蛋白共价连接的糖：(I) 其中A是基团(C═X)m，其中X是S或O，m是0或1；B是键、O或CH2；当m为0时，B也可以是(C═O)；R是C2-C16亚烷基、C2-C16杂亚烷基、NH-C(═O)-C2-C16亚烷基或NH-C(═O)-C2-C16杂亚烷基，其中所述亚烷基和杂亚烷基任选被1、2或3个独立选自COOR′的基团取代，其中R′选自H、甲基、乙基或丙基。本发明进一步涉及包含这种糖结合物的免疫原组合物，以及制备和使用这种糖结合物和免疫原组合物的方法。