| 129467-80-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧烷类
• CAS: 129467-80-7
• 化学式: C₁₃H₂₂O₂
• 分子量: 210.316
• InChiKey: QXLNTIZDNODPPD-WQDPKZQRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.37
• 重原子数：
  15.0
• 可旋转键数：
  0.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  29.46
• 氢给体数：
  1.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  以 乙醚 、 正戊烷 为溶剂， 生成
  参考文献：
  名称：

  Opening of oxabicyclo[3.2.1]octenes with organolithium reagents. A route to cyclic and acyclic compounds with high stereocontrol

  摘要：

  DOI：

  10.1021/jo00306a002
• 作为产物：
  描述：

  叔丁基锂 、 无 以 乙醚 为溶剂， 生成
  参考文献：
  名称：

  Opening of oxabicyclo[3.2.1]octenes with organolithium reagents. A route to cyclic and acyclic compounds with high stereocontrol

  摘要：

  DOI：

  10.1021/jo00306a002

文献信息

• INHIBITORS OF C-FMS KINASE
  申请人：Illig Carl R.

  公开号：US20090105296A1

  公开（公告）日：2009-04-23

  The invention is directed to compounds of Formula I: wherein Z, X, J, R 2 and W are set forth in the specification, as well as solvates, hydrates, tautomers and pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase. Methods of treating autoimmune diseases; and diseases with an inflammatory component; treating metastasis from ovarian cancer, uterine cancer, breast cancer, prostate cancer, lung cancer, colon cancer, stomach cancer, hairy cell leukemia; and treating pain, including skeletal pain caused by tumor metastasis or osteoarthritis, or visceral, inflammatory, and neurogenic pain; as well as osteoporosis, Paget's disease, and other diseases in which bone resorption mediates morbidity including rheumatoid arthritis, and other forms of inflammatory arthritis, osteoarthritis, prosthesis failure, osteolytic sarcoma, myeloma, and tumor metastasis to bone with the compounds of Formula I, are also provided.

  该发明涉及以下式I的化合物： 其中Z、X、J、R2和W如规范中所述，以及其溶剂化合物、水合物、互变异构体和药学上可接受的盐，能够抑制蛋白酪氨酸激酶，特别是c-fms激酶。本发明还提供了治疗自身免疫疾病；以及伴有炎症成分的疾病；治疗卵巢癌、子宫癌、乳腺癌、前列腺癌、肺癌、结肠癌、胃癌、毛细胞白血病的转移；以及治疗疼痛，包括肿瘤转移或骨关节炎引起的骨骼疼痛，或内脏、炎症和神经源性疼痛；以及骨质疏松症、帕盖特病和其他骨吸收介导发病率的疾病，包括类风湿性关节炎和其他形式的炎症性关节炎、骨关节炎、假体失败、溶骨性肉瘤、骨髓瘤和肿瘤转移至骨骼的方法，其中使用了式I的化合物。
• PROCESS FOR THE PREPARATION OF C-FMS KINASE INHIBITORS
  申请人：Janssen Pharmaceutica NV

  公开号：US20140045789A1

  公开（公告）日：2014-02-13

  The present invention is directed to a process for the preparation of heterocyclic derivatives of formula I wherein J, X, Z, and R 2 are as defined herein. Such compounds are useful as protein tyrosine kinase inhibitors, more particularly inhibitors of c-fms kinase.

  本发明涉及一种用于制备公式I的杂环衍生物的方法，其中J、X、Z和R2如本文所定义。这些化合物可用作蛋白酪氨酸激酶抑制剂，更具体地说是c-fms激酶的抑制剂。
• US8497376B2
  申请人：——

  公开号：US8497376B2

  公开（公告）日：2013-07-30
• US9029352B2
  申请人：——

  公开号：US9029352B2

  公开（公告）日：2015-05-12
• Opening of oxabicyclo[3.2.1]octenes with organolithium reagents. A route to cyclic and acyclic compounds with high stereocontrol
  作者：Mark Lautens、Alaa S. Abd-El-Aziz、Alan Lough

  DOI：10.1021/jo00306a002

  日期：1990.9