1,2-Dimethyl-5-phenyl-pyrrol | 828-80-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 1,2-Dimethyl-5-phenyl-pyrrol
• 英文别名: 1,2-Dimethyl-5-phenylpyrrole
• CAS: 828-80-8
• 化学式: C₁₂H₁₃N
• 分子量: 171.242
• InChiKey: LSAWDSLDHCHAQY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  4.9
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  1,2-Dimethyl-5-phenyl-pyrrol 、 bis(4-bromophenyl)iodonium tetrafluoroborate 在 双(乙腈)氯化钯(II) 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 2.08h， 以86%的产率得到3-(4-Bromophenyl)-1,2-dimethyl-5-phenylpyrrole
  参考文献：
  名称：

  Palladium-Catalyzed C−H Arylation of 2,5-Substituted Pyrroles

  摘要：

  The palladium-catalyzed direct arylation of 2,5-substituted pyrrole derivatives with diaryliodonium salts to generate tri-, tetra-, and penta-substituted pyrrole products is described. The scope and limitations of these transformations are also reported.

  DOI：

  10.1021/ol102734g
• 作为产物：
  描述：

  (1-methyl-5-phenyl-pyrrol-2-yl)-acetic acid 生成 1,2-Dimethyl-5-phenyl-pyrrol
  参考文献：
  名称：

  Lukes; Preucil, Collection of Czechoslovak Chemical Communications, 1935, vol. 7, p. 482,486

  摘要：

  DOI：

文献信息

• Visible-light photocatalyzed synthesis of 2-aryl N -methylpyrroles, furans and thiophenes utilizing arylsulfonyl chlorides as a coupling partner
  作者：Palani Natarajan、Anu Bala、S.K. Mehta、K.K. Bhasin

  DOI：10.1016/j.tet.2016.03.087

  日期：2016.5

  cross-coupling reactions of arylsulfonyl chloride with N-methylpyrrole, furan, thiophene and their derivatives have been achieved in moderate to good yields at room temperature. A plausible mechanism has been proposed for the reaction. The arylation takes place at the C–H bond (C2–H or C5–H) next to the heteroatom with a high regioselective manner! Moreover, arylsulfonyl chlorides utilized in this study are inexpensive

  可见光（蓝色LED灯：hν= 425±15 nm）在室温下以中等至良好的产率实现了芳基磺酰氯与N-甲基吡咯，呋喃，噻吩及其衍生物的光催化交叉偶联反应。已经提出了对该反应的合理机制。芳基化反应在杂原子旁的C–H键（C 2 –H或C 5 –H）上以高区域选择性的方式发生！此外，与以前报道的通过可见光光催化条件合成杂联芳基的方法中通常用作偶联伙伴的重氮盐相比，本研究中使用的芳基磺酰氯价格便宜，对环境无害，并且对温度，湿度和空气相对更稳定。
• Synthesis of 2-Formylpyrroles from Pyridinium Iodide Salts
  作者：Ke Xu、Wenjing Li、Rui Sun、Lihua Luo、Xue Chen、Chunchun Zhang、Xueli Zheng、Maolin Yuan、Haiyan Fu、Ruixiang Li、Hua Chen

  DOI：10.1021/acs.orglett.0c02178

  日期：2020.8.7

  synthesis of 2-formylpyrroles from pyridinium salts is reported. This protocol enables the synthesis of diversely substituted 2-formylpyrroles in good yields under operationally simple conditions. The detailed mechanistic studies reveal that the reaction proceeds via a novel H2O-triggered ring opening of the pyridinium salt and a subsequent intramolecularly nucleophilic addition sequence.

  据报道，由I 2介导的从吡啶鎓盐中合成2-甲酰基吡咯。该方案能够在操作简单的条件下以高收率合成各种取代的2-甲酰基吡咯。详细的机理研究表明，该反应是通过吡啶鎓盐的新颖的H 2 O触发的开环和随后的分子内亲核加成序列进行的。
• 1,2-DIHYDROPYRIDINE COMPOUNDS, MANUFACTURING METHOD THEREOF AND USE THEREOF
  申请人：NAGATO Satoshi

  公开号：US20090275751A1

  公开（公告）日：2009-11-05

  The present invention provides a novel compound having an excellent AMPA receptor inhibitory action and/or kainate inhibitory action. A compound represented by the following formula, a salt thereof or hydrates thereof. In the formula, Q indicates NH, O or S; and R 1 , R 2 , R 3 , R 4 and R 5 are the same as or different from each other and each indicates hydrogen atom, a halogen atom, a C 1-6 alkyl group or a group represented by the formula —X-A (wherein X indicates a single bond, an optionally substituted C 1-6 alkylene group etc.; and A indicates an optionally substituted C 6-14 aromatic hydrocarbocyclic group or 5- to 14-membered aromatic heterocyclic group etc.).

  本发明提供了一种新型化合物，具有优异的AMPA受体抑制作用和/或kainate抑制作用。该化合物的化学式如下，其盐或水合物：在该式中，Q表示NH、O或S；R1、R2、R3、R4和R5相同或不同，且每个表示氢原子、卤素原子、C1-6烷基或由式—X-A表示的基团（其中X表示单键、可选地取代的C1-6烷基等；A表示可选地取代的C6-14芳香烃环基或5-至14元杂环芳香族基等）。
• MULTI-COMPONENT HOST MATERIAL AND ORGANIC ELECTROLUMINESCENT DEVICE COMPRISING THE SAME
  申请人：Rohm And Haas Electronic Materials Korea Ltd.

  公开号：EP3636726A1

  公开（公告）日：2020-04-15

  The present invention relates to an organic electroluminescent device comprising at least one light-emitting layer between an anode and a cathode, wherein the light-emitting layer comprises a host and a phosphorescent dopant; the host comprises plural host compounds; at least a first host compound of the plural host compounds has a structure of a nitrogen-containing heterocyclic linker bonded to a nitrogen atom of a carbazole of an indole-carbazole, indene-carbazole, benzofuran-carbazole, or benzothiophene-carbazole residue; and a second host compound has a carbazole-aryl-carbazole or carbazole-carbazole structure. According to the present invention, by using a specific multi-component host different from the conventional organic electroluminescent device, an organic electroluminescent device of significantly improved lifespan is provided.

  本发明涉及一种有机电致发光器件，该器件包括阳极和阴极之间的至少一个发光层，其中发光层包括宿主和磷光掺杂剂；宿主包括多个宿主化合物；多个宿主化合物中至少有一个第一宿主化合物具有与吲哚-咔唑、茚-咔唑、苯并呋喃-咔唑或苯并噻吩-咔唑残基的咔唑的氮原子键合的含氮杂环连接体的结构；以及一个第二宿主化合物具有咔唑-芳基-咔唑或咔唑-咔唑结构。根据本发明，通过使用不同于传统有机电致发光器件的特定多组分宿主，提供了一种寿命显著提高的有机电致发光器件。
• COMPOUND FOR ORGANIC ELECTROLUMINESCENT ELEMENT AND ORGANIC ELECTROLUMINESCENT ELEMENT
  申请人：Nippon Steel Chemical Co., Ltd.

  公开号：EP1956022B1

  公开（公告）日：2012-07-25