2,3,4,5,6-五氟-N-(五氟苯基)苯甲酰胺 | 19364-92-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2,3,4,5,6-五氟-N-(五氟苯基)苯甲酰胺
• 英文名称: 2,3,4,5,6-pentafluoro-N-(pentafluorophenyl)benzamide
• 英文别名: 2,3,4,5,6-pentafluoro-N-pentafluorophenylbenzamide；2,3,4,5,6-pentafluoro-N-(2,3,4,5,6-pentafluorophenyl)benzamide
• CAS: 19364-92-2
• 化学式: C₁₃HF₁₀NO
• 分子量: 377.141
• InChiKey: PULQTXBGJPVSPD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  25
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  11

反应信息

• 作为反应物：
  描述：

  2,3,4,5,6-五氟-N-(五氟苯基)苯甲酰胺 在 五氯化磷 作用下， 以 二氯甲烷 为溶剂， 生成 N-Pentafluorophenyl(C-pentafluorophenyl)imidoyl chloride
  参考文献：
  名称：

  Fluorinated Bis(phenoxyketimine)titanium Complexes for the Living, Isoselective Polymerization of Propylene:  Multiblock Isotactic Polypropylene Copolymers via Sequential Monomer Addition

  摘要：

  A series of bis(phenoxyketimine)titanium dichloride complexes were synthesized and evaluated as catalysts for living, isoselective propylene polymerization upon activation with methylaluminoxane (MAO). Catalysts bearing phenoxyketimine ligands with different substituents at the ortho and para. positions of the phenolate ring and substituents at the ketimine carbon were investigated. The identity of the ketimine substituent had the largest effect on the activity and isoselectivity of propylene polymerization. Complex 12/MAO promoted the living, isoselective polymerization of propylene ([m(4)] = 0.73, alpha = 0.94). This catalyst system was used for the synthesis of a number of block copolymers featuring isotactic polypropylene semicrystalline blocks and poly(ethylene-co-propylene) amorphous blocks. Several triblock samples with varying block lengths, a pentablock, and a heptablock copolymer were synthesized. Mechanical testing has revealed that each is elastomeric with elongations at break between similar to 790-1000%.

  DOI：

  10.1021/ja077772g
• 作为产物：
  描述：

  N-pentafluorophenyl-pentafluorophenylaldimine 在 双氧水 、 溶剂黄146 作用下， 以 乙腈 为溶剂， 反应 20.0h， 生成 2,3,4,5,6-五氟-N-(五氟苯基)苯甲酰胺
  参考文献：
  名称：

  氟代芳族衍生物。CII。用过酸氧化氟化苯硅二烯苯胺

  摘要：

  用过酸处理亚苄基苯胺，其在偶氮甲胺基团的碳和氮上具有苯基和多氟苯基取代基，用过酸进行处理，得到了偶氮甲碱键裂解的产物。用乙酸过酸氧化C 6 F 5 CH XNC 6 F 4 X-4（X = H，F，CH 3，OCH 3）类型的多氟化合物可得到稳定的α-（多氟苯胺基）-2,3过氧化物， 4,5,6-五氟苄基化合物为终产物。报道了α-（五氟苯胺基）-2,3,4,5,6-五氟苄基过氧化物的X射线结构分析数据和一些化学性质。

  DOI：

  10.1016/s0022-1139(00)85191-x

文献信息

• METHOD FOR CONVERTING HYDROXYL GROUP OF ALCOHOL
  申请人：Takasago International Corporation

  公开号：US20210047254A1

  公开（公告）日：2021-02-18

  The present invention relates to: a method for converting a hydroxyl group of an alcohol; and a catalyst which makes the method possible. A method for converting a hydroxyl group of an alcohol according to the present invention is characterized by producing a compound represented by CH(R 1 )(R 2 )Nu (wherein R 1 , R 2 and Nu are as defined below) by reacting an alcohol represented by CH(R 1 )(R 2 )OH (wherein each of R 1 and R 2 represents a hydrogen atom, an optionally substituted alkyl group, or the like) and a compound having an active proton, which is represented by H-Nu (wherein Nu represents a group represented by —CHX 1 -EWG 1 or —NR 3 R 4 ; X 1 represents a hydrogen atom or the like; EWG 1 represents an electron-withdrawing group; and each of R 3 and R 4 represents a hydrogen atom, an optionally substituted alkyl group, or the like), with each other in the presence of a complex of a group 7-11 metal of the periodic table and at least one solid base that is selected from the group consisting of layered double hydroxides, composite oxides and calcium hydroxide.

  本发明涉及：将醇的羟基转化为的方法；以及使该方法成为可能的催化剂。根据本发明的将醇的羟基转化为的方法的特征在于，在周期表的7-11族金属群的复合物存在下，通过将一个由CH(R1)(R2)OH（其中R1和R2分别表示氢原子、可选择取代的烷基基团或类似物）表示的醇与一个具有活性质子的化合物（其中Nu表示由—CHX1-EWG1或—NR3R4表示的基团；X1表示氢原子或类似物；EWG1表示电子吸引基团；R3和R4分别表示氢原子、可选择取代的烷基基团或类似物）反应，从而产生一个由CH(R1)(R2)Nu（其中R1、R2和Nu如下定义）表示的化合物。同时，所述反应中至少选择一种来自层状双氢氧化物、复合氧化物和氢氧化钙的固体碱作为催化剂。
• Reactions of polyfluoroaromatic imidoyl chloride derivatives with S-nucleophilic reagents
  作者：T.D. Petrova、V.E. Platonov、L.N. Shchegoleva、A.M. Maksimov、A. Haas、M. Schelvis、M. Lieb

  DOI：10.1016/0022-1139(96)03465-3

  日期：1996.7

  N-pentafluorophenylcarbonimidoyl dichloride, N-pentafluorophenylbenzimidoyl chloride and N-pentafluorophenyl (C-pentafluorophenyl) imidoyl chloride with the S-nucleophilic reagents thiourea, sodiumN,N-diethyldithiocarbamate, thiocarbonyl difluoride and bis(trifluoromethyl)trithiocarbonate in the presence of CsF or AgSCF3, or thiophenol and polyfluorinated thiophenols in the presence of anhydrous K2CO3, were studied

  的相互作用Ñ -pentafluorophenylcarbonimidoyl二氯化物，Ñ -pentafluorophenylbenzimidoyl酰氯和Ñ -pentafluorophenyl（C-五氟苯基）亚氨酰氯与S-亲核试剂硫脲，钠盐N，N- -diethyldithiocarbamate，在存在硫代羰基二氟化物和双（三氟甲基）三硫代碳酸酯研究了在无水K 2 CO 3存在下的CsF或AgSCF 3，或苯硫酚和多氟化苯酚。在碱的存在下，与带电荷的S-亲核试剂和与S-亲核试剂的反应进行，从而在反应产物中保留了NC多重键。通过改变反应条件N-五氟苯基-汽车-亚氨基二氯可以取代一个或两个氯，得到一或二硫代亚氨酸酯。当C 6 ˚F 5或SC 6 ˚F 5个基团存在于该NC多重键的C原子，所述的优先的取代对位-氟原子发生。半经验PM3计算数据用于解释这些反应的方向。N-五氟苯基碳亚氨基二氯与N
• Reactions of N-(Pentafluorophenyl)carbonimidoyl Dichloride with Fluorinated Benzenes in the Presence of AlCl3
  作者：Tamara D. Petrova、Vyacheslav E. Platonov、Leonid M. Pokrovskii、Tatyana V. Rybalova、Yurii V. Gatilov

  DOI：10.1135/cccc20021449

  日期：——

  N-(Pentafluorophenyl)carbonimidoyl dichloride (1) reacts, in the presence of excess AlCl₃, with fluorinated benzenes containing 1-5 fluorine atoms in the molecule. With fluoro- and 1,3,5-trifluorobenzene the reaction gives the corresponding imidoyl chlorides and azomethines; at elevated temperatures, azomethines are formed in increased amounts. With 1,2,4,5-tetrafluorobenzene and pentafluorobenzene, intramolecular cyclization, leading to polyfluorinated 1,2,3,4-tetrahydroquinazoline-2,4-diones 9 is preferred. The side reactions are fluorine substitution with chlorine and formation of 1,3-bis(pentafluorophenyl)urea (10).

  N-(五氟苯基)碳亚胺二氯化物（1）在过量AlCl3存在下，与含有1-5个氟原子的氟化苯发生反应。与氟代苯和1,3,5-三氟苯反应会生成相应的亚胺氯化物和偶氮甲烷；在升高温度下，偶氮甲烷的生成量会增加。与1,2,4,5-四氟苯和五氟苯反应会发生分子内环化反应，导致多氟化的1,2,3,4-四氢喹啉-2,4-二酮（9）的形成更为优先。副反应包括氟与氯的取代反应以及1,3-双(五氟苯基)脲（10）的生成。
• Polyfluoroheterocyclic compounds. Part XIV. Some reactions of tetrafluoroisonicotinic acid and pentafluorobenzoic acid
  作者：R. D. Chambers、C. A. Heaton、W. K. R. Musgrave

  DOI：10.1039/j39680001933

  日期：——

  The anhydride and acid chloride of tetrafluoroisonicotinic acid have been made and used to prepare substituted amides and hydrazines. NN′-Di(tetrafluoroisonicotinoyl)hydrazine undergoes cyclodehydration when treated with phosphoryl chloride or phosphorus pentasulphide, to give 2,5-di(tetrafluoro-4-pyridyl)-1,3,4-oxadiazole and -thiadiazole respectively. Tetrafluoroisonicotinoyl fluoride reacts with

  已经制备了四氟异烟酸的酸酐和酰氯，并用于制备取代的酰胺和肼。神经网络当用磷酰氯或五硫化二磷处理时，'-二（四氟异烟酰基）肼经历环脱水作用，分别得到2,5-二（四氟-4-吡啶基）-1,3,4-恶二唑和-噻二唑。四氟异二十二碳酰氟与由六氟丙烯和氟离子制备的七氟异丙基阴离子反应，得到全氟（异丙基4-吡啶基酮）。其中一些反应已与五氟苯甲酰氯和五氟苯甲酰氟重复进行。除了与七氟异丙基阴离子形成酮外，后者还在环中进行亲核取代，从而得到全氟（异丙基4-异丙基苯基酮）。
• Vlasov, V. M.; Terekhova, M. I.; Petrov, E. S., Journal of Organic Chemistry USSR (English Translation), 1981, vol. 17, # 10, p. 1807 - 1813
  作者：Vlasov, V. M.、Terekhova, M. I.、Petrov, E. S.、Shatenshtein, A. I.、Yakobson, G. G.

  DOI：——

  日期：——