trans-4-pyridine | 18096-82-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: trans-4-pyridine
• 英文别名: N,N-diethyl-N-[4-(2-(pyridin-4-yl)ethenyl)phenyl]amine；N,N-diethyl-4-[(E)-2-(pyridin-4-yl)ethenyl]aniline；(E)-(4-diethylanilinostyryl)pyridine；N,N-diethyl-4-((E)-2-(pyridin-4-yl)vinyl)benzenamine；N,N-diethyl-N-{4-[(E)-2-(4-pyridinyl)ethenyl]phenyl}amine；(E)-N,N-diethyl-4-(2-(pyridin-4-yl)vinyl)aniline；4-<4-Diethylamino-styryl>-pyridin；trans-4-(4-Diethylamino-styryl)-pyridin；4-(4-diethylaminostyryl)pyridine；N,N-Diaethyl-4-(trans-2-[4]pyridyl-vinyl)-anilin；N,N-diethyl-4-(trans-2-[4]pyridyl-vinyl)-aniline；N,N-diethyl-4-(2-pyridin-4-yl-vinyl)-aniline；4'-diethylamino-4-stilbazole；n,n-Diethyl-4-[2-(pyridin-4-yl)ethenyl]aniline；N,N-diethyl-4-[(E)-2-pyridin-4-ylethenyl]aniline
• CAS: 18096-82-7
• 化学式: C₁₇H₂₀N₂
• 分子量: 252.359
• InChiKey: ZHORASYCHBCYLU-AATRIKPKSA-N

物化性质

• 沸点：
  408.0±24.0 °C(Predicted)
• 密度：
  1.065±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  16.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  trans-4-pyridine 、 zinc(II) thiocyanate 以 甲醇 为溶剂， 反应 2.0h， 以81%的产率得到Zn(SCN)₂((E)-(4-diethylanilinostyryl)pyridine₎₂
  参考文献：
  名称：

  Self-assembly of a series of thiocyanate complexes with high two-photon absorbing active in near-IR range and bioimaging applications

  摘要：

  A series of novel complexes bearing high fluorescence quantum yields and showing the peak two-photon absorption (2 PA) cross-sections in the near-infrared region, Zn(SCN)(2)L-2 (1), [Cd(SCN)(2)L-2](n) (2), Co(SCN)(2)L-4 (3), Ni(SCN)(2)L-4 (4), [CdHgL2(SCN)(4)](n) (5) and [MnHg(SCN)(4)L-2](n) (6), containing functional chromophore (L = (E)-(4-diethyl anilinostyryl)pyridine), were synthesized in high yields. Crystal structures of all the complexes were confirmed. Hetero-metal complexes (5, 6: L:M = 1:1) present much higher two-photon absorption (2 PA) cross-sections (sigma) in comparison with those of the homo-metal complexes (L:M = 4:1 in 3 and 4, L:M = 2:1 in 1 and 2) and the free ligand (L) which may due to the fact that the hetero-metal complexes have more bridged anions (SCN-), conjugated subunits -[Hg(SCN)(2)M]- and -[Hg-2(SCN)(4)M-2]-. In addition, the results revealed that 2 PA response was much enhanced for the Zn(SCN)(2)L-2 and two-photon fluorescence cell imaging experiment proved its potential application. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.dyepig.2015.03.039
• 作为产物：
  描述：

  对氟苯甲醛 在 氢化钾 、 甲基三辛基氯化铵 、 potassium carbonate 、 叔丁醇 作用下， 以 二甲基亚砜 为溶剂， 反应 74.0h， 生成 trans-4-pyridine
  参考文献：
  名称：

  Self-assembly of a series of thiocyanate complexes with high two-photon absorbing active in near-IR range and bioimaging applications

  摘要：

  A series of novel complexes bearing high fluorescence quantum yields and showing the peak two-photon absorption (2 PA) cross-sections in the near-infrared region, Zn(SCN)(2)L-2 (1), [Cd(SCN)(2)L-2](n) (2), Co(SCN)(2)L-4 (3), Ni(SCN)(2)L-4 (4), [CdHgL2(SCN)(4)](n) (5) and [MnHg(SCN)(4)L-2](n) (6), containing functional chromophore (L = (E)-(4-diethyl anilinostyryl)pyridine), were synthesized in high yields. Crystal structures of all the complexes were confirmed. Hetero-metal complexes (5, 6: L:M = 1:1) present much higher two-photon absorption (2 PA) cross-sections (sigma) in comparison with those of the homo-metal complexes (L:M = 4:1 in 3 and 4, L:M = 2:1 in 1 and 2) and the free ligand (L) which may due to the fact that the hetero-metal complexes have more bridged anions (SCN-), conjugated subunits -[Hg(SCN)(2)M]- and -[Hg-2(SCN)(4)M-2]-. In addition, the results revealed that 2 PA response was much enhanced for the Zn(SCN)(2)L-2 and two-photon fluorescence cell imaging experiment proved its potential application. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.dyepig.2015.03.039

文献信息

• Proton-controlled photoisomerization: rhenium(i) tricarbonyl bipyridine linked to amine or azacrown ether groups by a styryl pyridine bridging ligand
  作者：Jared D. Lewis、Robin N. Perutz、John N. Moore

  DOI：10.1039/b005889k

  日期：——

  Complexes in which fac-(bpy)Re(CO)3 is linked by a styryl pyridine to an amine or an azacrown ether show no photoreaction in acetonitrile in the absence of acid, but they photoisomerize readily at the stilbene-like bridging ligand when the terminal amine or azacrown ether group is protonated because an intramolecular energy-transfer mechanism becomes available.

  fac-(bpy)Re(CO)3 通过苯乙烯基吡啶与胺或氮杂冠醚连接的配合物在没有酸的情况下在乙腈中没有显示出光反应，但当末端胺或氮杂冠醚基团被质子化，因为分子内能量转移机制变得可用。
• Series of C^N^C Cyclometalated Pt(II) Complexes: Synthesis, Crystal Structures, and Nonlinear Optical Properties in the Near-Infrared Region
  作者：Bin Fang、Yingzhong Zhu、Lei Hu、Yu Shen、Guoqing Jiang、Qiong Zhang、Xiaohe Tian、Shengli Li、Hongping Zhou、Jieying Wu、Yupeng Tian

  DOI：10.1021/acs.inorgchem.8b01967

  日期：2018.11.19

  It is currently challenged that nonlinear optical (NLO) properties in the near-infrared region (NIR) of metal complexes can be tunable with an assistant ligand. Herein, the linear and nonlinear photophysical properties of the novel C^N^C cyclometalated Pt(II) complexes with different substituents as auxiliary ligands are presented. The complexes displayed intense triplet metal/ligand-to-ligand charge-transfer

  当前面临的挑战是，金属配合物的近红外区域（NIR）中的非线性光学（NLO）特性可以通过辅助配体进行调节。本文介绍了具有不同取代基作为辅助配体的新型C ^ N ^ C环金属化Pt（II）配合物的线性和非线性光物理性质。复合物显示强烈的三重态的金属/配体-配体电荷转移（3 MLCT / 3 LLCT）和intraligand 3 π，π*在低温发射。TD-DFT计算，瞬态吸收和发射寿命进一步证实了激发态特性。该铂3具有相对较高的量子产率（9.1％），中等的三重态激发态寿命（5.32μs），以及从可见光到近红外区域的宽激发态吸收。有趣的是，我们发现了Pt-3表现出高2PA横截面的值（σ 2到367 GM在820纳米），以及良好的光学性质限制在一个可调谐飞秒激光。在晶体结构信息的基础上，系统地研究了结构与性能之间的关系。因此，环金属化的Pt（II）配合物将成为NIR NLO材料应用的候选者。
• Synthesis, crystal structures, and solid state quadratic nonlinear optical properties of a series of stilbazolium cations combined with gold cyanide counter-ion
  作者：Pascal G. Lacroix、M. Carmen Munoz、Ana Belén Gaspar、José Antonio Real、Sébastien Bonhommeau、Vincent Rodriguez、Keitaro Nakatani

  DOI：10.1039/c1jm12105g

  日期：——

  Three salts built up from (E)-4′-(dimethylamino)-stilbazolium (DMAS)H+, (E)-4′-(diethylamino)-stilbazolium (DEAS)H+, (E)-4′-2-(methoxymethyl) pyrrolidinyl}-stilbazolium (MPS)H+, and gold cyanide as a counter-ion, are reported. The crystal structures have been solved for (DEAS)H+ Au(CN)2− (Cc space group), and for (MPS)H+ Au(CN)2− (P1 space group). The semi-empirical (ZINDO) calculated static hyperpolarizability (β0) of (MPS)H+ is equal to 147 × 10−30 cm5esu−1, in solid state, which is 25% higher than that of the cation of the well known (E)-4′-(dimethylamino)-methylstilbazolium tosylate (DAST). (MPS)H+ Au(CN)2− exhibits a unique crystal structure in which the cations are perfectly aligned. This combination of large hyperpolarizability and strict 1-dimensional character leads to a giant dzzz quadratic susceptibility (χ(2)) tensor component estimated between ∼4500 pm V−1 (∼11 × 10−6 esu) and 12 400 pm V−1 (∼30 × 10−6 esu) at 1.064 μm, by a confocal μ-SHG technique. The use of such material in ultra-thin devices is critically evaluated.

  报告了由(E)-4′-(二甲基氨基)-芪(DMAS)H+、(E)-4′-(二乙基氨基)-芪(DEAS)H+、(E)-4′-2-(甲氧基甲基)吡咯烷基}-芪(MPS)H+和作为反离子的氰化金生成的三种盐。(DEAS)H+ Au(CN)2-（Cc 空间群）和 (MPS)H+ Au(CN)2-（P1 空间群）的晶体结构已经解决。在固态下，(MPS)H+ 的半经验（ZINDO）计算静态超极化率（β0）等于 147 × 10-30 cm5esu-1，比已知的 (E)-4′-(dimethylamino)-methylstilbazolium tosylate (DAST) 阳离子的超极化率高 25%。(MPS)H+ Au(CN)2- 具有独特的晶体结构，其中的阳离子完全对齐。通过共焦μ-SHG 技术，在 1.064 μm 处，这种大超极化性和严格的一维特性相结合，产生了巨大的 dzzz 二次方电感（χ(2)）张量分量，估计介于 ∼4500 pm V-1 (∼11 × 10-6 esu) 和 12 400 pm V-1 (∼30 × 10-6 esu) 之间。对这种材料在超薄设备中的应用进行了严格评估。
• A novel ratiometric fluorescence probe based on the FRET-ICT mechanism for detecting fluoride ions and viscosity
  作者：Yi Zheng、Shu-Mei Zhai、Meng-Min Xiao、Pei-Zhen Dong、Jia-Rui Xu、Bao-Xiang Zhao

  DOI：10.1016/j.saa.2023.123822

  日期：2024.3

  Fluoride ion is not only important for dental health, but also a contributing factor in a variety of diseases. At the same time, fluoride ions and cell viscosity are both important to the physiological environment of mitochondria. We developed a dual-response ratiometric fluorescent probe BDF based on Förster resonance energy transfer (FRET) and intramolecular charge transfer (ICT) mechanism for the

  氟离子不仅对牙齿健康很重要，而且还是多种疾病的促成因素。同时，氟离子和细胞粘度对于线粒体的生理环境都很重要。我们开发了一种基于福斯特共振能量转移（FRET）和分子内电荷转移（ICT）机制的双响应比率荧光探针BDF ，用于检测F -和粘度。 BDF具有高达 97.7% 的出色分子内能量转移效率，在氟离子检测方面表现出优异的性能。此外，当体系粘度增加时， BDF的荧光发射强度大大增强，表明粘度检测的可能性。最后，基于BDF的荧光特性，我们使用探针检测牙膏样品中的F-并对HeLa细胞中的外源氟离子进行成像。
• Therapeutic inhibitor for EBV-associated tumor with tailor responsive optical imaging
  申请人：Hong Kong Baptist University

  公开号：US10842846B2

  公开（公告）日：2020-11-24

  The present disclosure provides peptides useful as inhibitors of the dimerization interface of EBNA1. The present disclosure also provides methods for treating and imaging EBV-associated cancers.

  本公开提供了可用作 EBNA1 二聚化界面抑制剂的多肽。本公开还提供了用于治疗和成像 EBV 相关癌症的方法。