2,4,6-三氯苯乙醚 | 23399-88-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: 2,4,6-三氯苯乙醚
• 英文名称: 2,4,6-trichlorophenyl ethyl ether
• 英文别名: 2,4,6-trichloro-phenetole；2.4.6-Trichlor-1-aethoxy-benzol；2,4,6-Trichlor-phenetol；Aethyl-(2.4.6-trichlor-phenyl)-aether；Ethyl-(2.4.6-trichlorphenyl)-ether；Aethyl-2,4-6-trichlorphenylaether；2,4,6-Trichlorophenetole；1,3,5-trichloro-2-ethoxybenzene
• CAS: 23399-88-4
• 化学式: C₈H₇Cl₃O
• 分子量: 225.502
• InChiKey: GYDFVBYBCDOBFE-UHFFFAOYSA-N

物化性质

• 保留指数：
  1397.8

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 海关编码：
  2909309090

反应信息

• 作为反应物：
  描述：

  2,4,6-三氯苯乙醚 在 硫酸 、 硝酸 作用下， 生成 2,4,6-trichloro-3,5-dinitro-phenetole
  参考文献：
  名称：

  A Nested PCR Assay to Detect DNA in Sera for the Diagnosis of Deep-Seated Trichosporonosis

  摘要：

  AbstractDeep‐seated trichosporonosis caused by Trichosporon asahii has a high mortality rate and a very poor prognosis. New species‐specific oligonucleotide primers for T. asahii were developed from a sequence analysis of rRNA genes that included the internal transcribed spacer regions. A nested PCR assay with specific primers was used to examine 11 serum samples from 7 patients, who were diagnosed with deep‐seated trichosporonosis histologically at autopsy. In addition, Trichosporon cell wall polysaccharide (PS) was detected by a latex agglutination (LA) test. Of 11 samples, seven had a positive LA test, and T. asahii DNA was also detected with the nested PCR assay. Of the four samples in which PS antigen was not detected, the nested PCR of two samples was positive. Our new nested PCR assay may be used as an adjunct to conventional methods for diagnosing T. asahii infection.

  DOI：

  10.1111/j.1348-0421.2001.tb01282.x
• 作为产物：
  描述：

  sodium 2,4,6-trichlorophenolate 生成 2,4,6-三氯苯乙醚
  参考文献：
  名称：

  ZANKE, D.;EDLICH, W., TAGUNSBER. AKAD. LANDWIRTSCHAFTSWISS. DDR,(1987) N 253, 283-288

  摘要：

  DOI：

文献信息

• SNAAP Sulfonimidate Alkylating Agent for Acids, Alcohols, and Phenols
  作者：Tom Maricich、Matthew Allan、Brett Kislin、Andrea Chen、Fan-Chun Meng、Christine Bradford、Nai-Chia Kuan、Jeremy Wood、Omonigho Aisagbonhi、Alethea Poste、Dustin Wride、Sylvia Kim、Therese Santos、Michael Fimbres、Dianne Choi、Haydi Elia、Joseph Kaladjian、Ali Abou-Zahr、Arturo Mejia

  DOI：10.1055/s-0033-1339921

  日期：——

  iodoethane and silver(I) oxide in dichloromethane. This sulfonimidate directly ethylates various acids to esters; the stronger the acid, the faster it alkylates and in higher yield. It readily ethylates alcohols and phenols to ethers at room temperature in the presence of tetrafluoroboric acid catalyst without molecular rearrangements or racemization. We have defined these reactions as SNAAP alkylations:

  摘要 稳定，晶状ñ -叔丁基-4- nitrobenzenesulfonimidate已经通过直接O形乙基高收率制备ñ -叔丁基-4-硝基苯磺酰胺与碘乙烷和二氯甲烷银（I）氧化物。该亚磺酸磺酸盐将各种酸直接乙基化为酯。酸越强，烷基化速度越快，收率越高。在四氟硼酸催化剂存在下，在室温下容易将醇和酚乙基化为醚，而不会发生分子重排或外消旋化。我们定义这些反应如烷基化SNAAP：小号ubstitution，Ñ的ucleophilic一个的CID，一个lcohols和p henols]。所述硬sulfonimidate烷化剂是化学选择性的，宁愿氧气>氮气>硫。烷基化的磺酰胺副产物易于再循环至磺酰亚胺酯。 稳定，晶状ñ -叔丁基-4- nitrobenzenesulfonimidate已经通过直接O形乙基高收率制备ñ -叔丁基-4-硝基苯磺酰胺与碘乙烷和二氯甲烷银（I）氧化物。该亚磺酸磺酸盐将各种酸直
• ACTIVATED CYTOTOXIC COMPOUNDS FOR ATTACHMENT TO TARGETING MOLECULES FOR THE TREATMENT OF MAMMALIAN DISEASE CONDITIONS
  申请人：Fegley Glenn

  公开号：US20100022615A1

  公开（公告）日：2010-01-28

  Activated cytotoxic compounds are described for attachment to targeting molecules for the treatment of a mammalian disease condition which comprise, an activator, a spacer linker, a linker (e.g., self-immolative), and a cytotoxic drug selected from the group consisting of AMINO-SUBSTITUTED (E)-2,6-DIALKOXYSTYRYL 4-SUBSTITUTED BENZYLSULFONES, AMINO-AND-HYDROXY SUBSTITUTED STYRYLSULFONANILIDES, and SUBSTITUTED PHENOXY- AND PHENYLTHIO-STYRYLSULFONE DERIVATIVES. Activated cytotoxic compound attached to a targeting molecule are described wherein the targeting molecule is selected from the group consisting essentially of an antibody, a receptor, a ligand, a cytokine, a hormone, and a signal transduction molecule. The invention is further directed to a method of treatment of disease conditions.

  本发明涉及一种激活的细胞毒性化合物，用于附着于靶向分子治疗哺乳动物疾病状况，包括激活剂、间隔连接剂、连接剂（例如自解性连接剂）和从AMINO-SUBSTITUTED（E）-2,6-DIALKOXYSTYRYL 4-SUBSTITUTED BENZYLSULFONES、AMINO-AND-HYDROXY SUBSTITUTED STYRYLSULFONANILIDES和SUBSTITUTED PHENOXY-AND PHENYLTHIO-STYRYLSULFONE DERIVATIVES组成的细胞毒性药物。本发明还涉及附着于靶向分子的激活的细胞毒性化合物，其中靶向分子从抗体、受体、配体、细胞因子、激素和信号转导分子等组成的群体中选择。本发明进一步涉及一种治疗疾病状况的方法。
• Ketene Acetals. VII.¹ The Reaction of Ketene Diethylacetal with Various Halogen Compounds and Acids
  作者：S. M. McElvain、D. Kundiger

  DOI：10.1021/ja01254a015

  日期：1942.2
• Formation of nonaromatic products in the chlorination of simple substituted aromatic ethers
  作者：William David Watson

  DOI：10.1021/jo00148a009

  日期：1982.12
• Accurate Determination of 2,4,6-Trichloroanisole in Wines at Low Parts Per Trillion by Solid-Phase Microextraction Followed by GC-ECD
  作者：Roberto Alzaga、Laura Ortiz、Francisco Sánchez-Baeza、M.-Pilar Marco、Josep Maria Bayona

  DOI：10.1021/jf0211682

  日期：2003.6.1

  A headspace solid-phase microextraction (HS-SPME) procedure at 30 degreesC with a 100 mum PDMS fiber of a saturated NaCl solution stirred at 1100 rpm combined to GC-ECD for the 2,4,6-trichloroanisol (TCA) determination in wines has been developed. Due to the matrix complexity and ethanol absorption into the fiber, the internal standard selection was crucial to obtain unbiased results. Thus, matrix effects were observed when analyzing different types of Spanish wines (white, early, and vintage red wines) spiked with TCA at low concentration levels (i.e., <40 ng L-1). In contrast, the use of 2,4,6-tribromoanisole (TBA) as internal standard overcame these matrix effects, whereas the use of 2,4,6-trichlorophenyl ethyl ether led to inconsistent results. The developed HS-SPME-GC-ECD methodology reaches a limit of quantitation for TCA in wine within 2.9-18 ng L-1, with a relative standard deviation of 2.5-13.4%, depending on the TCA concentration level and wine characteristics. This analytical method is comparable to the existing methodologies based on HS-SPME followed by GC-MS in terms of accuracy, precision, length of determination, and length of quantification; however, analysis cost is reduced.