4-苯基萘-1-胺 | 87833-80-5

• 物质功能分类: 化学试剂 - 有机试剂 - 多环化合物
• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: 4-苯基萘-1-胺
• 中文别名: 1-氨基-4-苯基萘
• 英文名称: 4-phenylnaphthalen-1-amine
• CAS: 87833-80-5
• 化学式: C₁₆H₁₃N
• 分子量: 219.286
• InChiKey: HPNTZCAYLSSXRP-UHFFFAOYSA-N

物化性质

• 熔点：
  73-74 °C
• 沸点：
  140-146 °C(Press: 14 Torr)
• 密度：
  1.147±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4-苯基萘-1-胺 在 四(三苯基膦)钯 potassium carbonate 、 三氯氧磷 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 16.0h， 生成 4-氯-2,6-二苯基苯并[H]喹啉
  参考文献：
  名称：

  COMPOUND FOR AN ORGANIC OPTOELECTRONIC DEVICE, ORGANIC LIGHT EMITTING DIODE INCLUDING THE SAME, AND DISPLAY INCLUDING THE ORGANIC LIGHT EMITTING DIODE

  摘要：

  一种用于有机光电器件、有机发光二极管和显示器件的化合物，该化合物由以下化学式1表示：

  公开号：

  US20120280613A1
• 作为产物：
  描述：

  3,4-二氢-1-苯基萘 在 盐酸 、 硝酸 、 sulfur 、 溶剂黄146 、 tin(ll) chloride 作用下， 生成 4-苯基萘-1-胺
  参考文献：
  名称：

  Weiss; Woidich, Monatshefte fur Chemie, 1925, vol. 46, p. 457

  摘要：

  DOI：

文献信息

• AROMATIC AMINE DERIVATIVE AND ORGANIC ELECTROLUMINESCENT DEVICE USING SAME
  申请人：Idemitsu Kosan Co., Ltd.

  公开号：EP1997799A1

  公开（公告）日：2008-12-03

  Provided are a novel aromatic amine derivative represented by the following general formula (1) and an organic electroluminescent device including an organic thin film formed of one or a plurality of layers including at least a light emitting layer interposed between a cathode and an anode, in which at least one layer of the organic thin film contains the aromatic amine derivative alone or as a component of a mixture, which contributes to suppressing molecular crystallization and improving yield in the production of an organic electroluminescent device, whereby an organic electroluminescent device having a long lifetime can be obtained, and the aromatic amine derivative is capable of realizing the organic electroluminescent device: where: R1 represents an aryl group or the like; a represents an integer of 0 to 4; b represents an integer of 1 to 3; and at least one of Ar1 to Ar4 represents a group represented by the following general formula (2): where Ar5 represents a fused aromatic ring group and Ar6 represents an aryl group or an aromatic heterocyclic group, where remaining groups of Ar1 to Ar4, none of which is represented by the general formula (2), each independently represent an aryl group or an aromatic heterocyclic group.

  提供了一种由以下一般式（1）表示的新型芳香胺衍生物，以及包括由至少一个或多个层次组成的有机薄膜的有机电致发光装置，其中有机薄膜的至少一层包含仅芳香胺衍生物或作为混合物成分的芳香胺衍生物，有助于抑制分子结晶并提高有机电致发光装置的产量，从而可以获得寿命长的有机电致发光装置，且该芳香胺衍生物能够实现该有机电致发光装置： 其中：R1代表芳基或类似物；a代表0到4的整数；b代表1到3的整数；Ar1至Ar4中至少一个代表由以下一般式（2）表示的基团： 其中Ar5代表融合芳香环基团，Ar6代表芳基或芳香杂环基团， Ar1至Ar4的其余基团，其中没有一个被一般式（2）表示，各自独立地代表芳基或芳香杂环基团。
• Ruthenium(II)-Catalyzed <i>Ortho</i>-C–H Alkylation of Naphthylamines with Diazo Compounds for Synthesis of 2,2-Disubstituted π-Extended 3-Oxindoles in Water
  作者：Xiaogang Wang、Jin Zhang、Yuan He、Di Chen、Chao Wang、Fangzhou Yang、Weitao Wang、Yangmin Ma、Michal Szostak

  DOI：10.1021/acs.orglett.0c01811

  日期：2020.7.2

  Ruthenium(II)-catalyzed ortho-C–H alkylation of naphthylamines with diazo compounds for the synthesis of 2,2-disubstituted π-extended 3-oxindoles has been developed. The method represents the first example of C–H alkylation via carbenoid insertion in water as a sustainable solvent. The procedure includes an inexpensive ruthenium catalyst as well as aqueous media and results in the release of benign

  已经开发了钌（II）催化的萘胺与重氮化合物的邻位C-H烷基化反应，用于合成2,2-二取代的π-延伸的3-氧吲哚。该方法代表了通过类胡萝卜素插入水中作为可持续溶剂进行C–H烷基化的第一个例子。该过程包括廉价的钌催化剂以及水性介质，并导致良性N 2的释放。π-扩展的3-氧吲哚产物在用于荧光成像的水溶液中显示出良好的抗肿瘤性能和显着的荧光性能。
• Free‐Amine‐Directed Iridium‐Catalyzed C−H Bond Activation and Cyclization of Naphthalen‐1‐amines with Diazo Compounds Leading to Naphtho[1,8‐ <i>bc</i> ]pyridines
  作者：Kelu Yan、Yongxue Lin、Yong Kong、Bin Li、Baiquan Wang

  DOI：10.1002/adsc.201801598

  日期：2019.4

  Iridium‐catalyzed C−H activation and cyclization of naphthalen‐1‐amines with diazo compounds leading to naphtho[1,8‐bc]pyridines have been developed. Different from the previous free‐amine‐directed C−H functionalization with diazo compounds that relied on the coordination of lone pair electrons or in situ formation of imine, this transformation passes through a five‐membered iridacycle intermediate containing an

  已经开发了铱催化的CH-1活化和萘-1-胺与重氮化合物的环合反应，从而生成萘[1,8- bc ]吡啶。与以前的重氮化合物基于孤对电子的配位或亚胺的原位形成的重氮化合物的游离胺定向的CH官能化不同，该转化过程通过包含N-Irσ-键的五元iridacycle中间体进行。 。它为在温和条件下合成有用的各种萘并[1,8- bc ]吡啶衍生物提供了另一种方法。
• Aurora Kinase Modulators and Method of Use
  申请人：Amgen Inc.

  公开号：US20140336182A1

  公开（公告）日：2014-11-13

  The present invention relates to chemical compounds having a general formula I wherein A 1-8 , D′, L 1 , L 2 , R 1 , R 6-8 and n are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of such kinases. For example, the compounds are capable of modulating Aurora kinase thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of Aurora kinase.

  本发明涉及具有一般式I的化合物，其中A1-8、D'、L1、L2、R1、R6-8和n在此处定义，并且具有调节各种蛋白激酶受体酶并因此影响与这些激酶活动相关的各种疾病状态和病况的能力的合成中间体。例如，这些化合物能够调节枢纽激酶，从而影响细胞周期和细胞增殖过程，以治疗癌症和与癌症相关的疾病。该发明还包括包括这些化合物的药物组合物，以及治疗与枢纽激酶活性相关的疾病状态的方法。
• Aromatic substitution by phenylnitrenium and naphthylnitrenium ions formed from phenyl azide and 1-azidonaphthalene in the presence of trifluoromethanesulphonic acid
  作者：Hiroshi Takeuchi、Katsuyuki Takano

  DOI：10.1039/c39830000447

  日期：——

  Aromatic N-substitution by phenylnitrenium ions generated from phenyl azide in the presence of a catalytic amount of trifluoromethanesulphonic acid gave diarylamines (in especially good yield in the reactions with biphenyl or naphthalene), whereas naphthylnitrenium ions from 1-azidonaphthalene react with benzene to afford a C-substitution product, 1-amino-4-phenylnaphthalene.

  在催化量的三氟甲磺酸存在下，由叠氮化物生成的苯氮化物离子芳香N取代生成二芳基胺（与联苯或萘的反应收率特别高），而1-叠氮萘的萘氮化萘离子与苯反应生成苯甲酰胺。C-取代产物1-氨基-4-苯基萘。