Ethyl 4-[benzenesulfonyl(methyl)amino]benzoate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Ethyl 4-[benzenesulfonyl(methyl)amino]benzoate
• 化学式: C₁₆H₁₇NO₄S
• 分子量: 319.381
• InChiKey: OUQJSCNLCGTNKS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  72.1
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  Ethyl 4-[benzenesulfonyl(methyl)amino]benzoate 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 以62 %的产率得到N-[4-(hydroxymethyl)phenyl]-N-methylbenzenesulfonamide
  参考文献：
  名称：

  [EN] SMALL MOLECULE INHIBITORS OF THE CRL4 UBIQUITIN LIGASE
  [FR] INHIBITEURS À PETITES MOLÉCULES DE L'UBIQUITINE LIGASE CRL4

  摘要：

  Compounds of formula (I), compounds of formula (II), and compounds of formula (III) are disclosed. Also disclosed are compounds, compositions, and methods to inhibit CUL4A expression or activity, CUL4B expression or activity, and/or DDB1 expression or activity for the treatment or prevention of cancer, DNA damage, or related conditions. In some aspects, the interaction between CUL4A and/or CUL4B and the beta-propeller B of DDB1 is disrupted with the compounds, compositions, or methods.

  公开号：

  WO2023173136A2
• 作为产物：
  描述：

  苯磺酰氯 在 吡啶 、 potassium carbonate 作用下， 以 四氢呋喃 为溶剂， 反应 24.0h， 生成 Ethyl 4-[benzenesulfonyl(methyl)amino]benzoate
  参考文献：
  名称：

  [EN] SMALL MOLECULE INHIBITORS OF THE CRL4 UBIQUITIN LIGASE
  [FR] INHIBITEURS À PETITES MOLÉCULES DE L'UBIQUITINE LIGASE CRL4

  摘要：

  Compounds of formula (I), compounds of formula (II), and compounds of formula (III) are disclosed. Also disclosed are compounds, compositions, and methods to inhibit CUL4A expression or activity, CUL4B expression or activity, and/or DDB1 expression or activity for the treatment or prevention of cancer, DNA damage, or related conditions. In some aspects, the interaction between CUL4A and/or CUL4B and the beta-propeller B of DDB1 is disrupted with the compounds, compositions, or methods.

  公开号：

  WO2023173136A2

文献信息

• Copper-catalyzed cross-coupling of sulfonamides with aryl iodides and bromides facilitated by amino acid ligands
  作者：Wei Deng、Lei Liu、Chen Zhang、Min Liu、Qing-Xiang Guo

  DOI：10.1016/j.tetlet.2005.08.149

  日期：2005.10

  A highly general, convenient, and inexpensive catalyst system was developed for the N-arylation of sulfonamides with aryl iodides or bromides by using 5–20 mol % of CuI as catalyst, 20 mol % of N-methylglycine (for aryl iodides) or N,N-dimethylglycine (for aryl bromides) as ligand, and K3PO4 as base.

  高度通常，方便，廉价的催化剂体系用于将显影Ñ通过使用5-20％（摩尔）的CuI作为催化剂的，20摩尔％的与芳基碘化物或溴化物磺胺-arylation Ñ -methylglycine（为芳基碘化物）或ñ，N-二甲基甘氨酸（对于芳基溴化物）为配体，K 3 PO 4为碱。
• [EN] SMALL MOLECULE INHIBITORS OF THE CRL4 UBIQUITIN LIGASE<br/>[FR] INHIBITEURS À PETITES MOLÉCULES DE L'UBIQUITINE LIGASE CRL4
  申请人：[en]CORNELL UNIVERSITY

  公开号：WO2023173136A2

  公开（公告）日：2023-09-14

  Compounds of formula (I), compounds of formula (II), and compounds of formula (III) are disclosed. Also disclosed are compounds, compositions, and methods to inhibit CUL4A expression or activity, CUL4B expression or activity, and/or DDB1 expression or activity for the treatment or prevention of cancer, DNA damage, or related conditions. In some aspects, the interaction between CUL4A and/or CUL4B and the beta-propeller B of DDB1 is disrupted with the compounds, compositions, or methods.