(S)-2-(3-bromopyridin-2-ylamino)propan-1-ol | 1234623-03-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: (S)-2-(3-bromopyridin-2-ylamino)propan-1-ol
• 英文别名: (S)-2-(3-Bromopyridin-2-ylamino)propan-1-ol；(2S)-2-[(3-bromopyridin-2-yl)amino]propan-1-ol
• CAS: 1234623-03-0
• 化学式: C₈H₁₁BrN₂O
• 分子量: 231.092
• InChiKey: INZAWDRVDDLXQC-LURJTMIESA-N

物化性质

• 沸点：
  344.0±32.0 °C(Predicted)
• 密度：
  1.548±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  45.2
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (S)-2-(3-bromopyridin-2-ylamino)propan-1-ol 在 palladium diacetate 、 caesium carbonate 、 2-(二叔丁基膦)联苯 作用下， 以 甲苯 为溶剂， 以74%的产率得到(S)-3-methyl-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine
  参考文献：
  名称：

  Microwave-assisted amination of 3-bromo-2-chloropyridine with various substituted aminoethanols

  摘要：

  A simple method for microwave-assisted amination of 3-bromo-2-chloropyridine with various substituted aminoethanols is described. The reaction was carried out under microwave irradiation conditions (at 180 degrees C for 1-2 h) and the result was superior in terms of conversion and yield when compared to that of the corresponding conventional heating conditions. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.05.021
• 作为产物：
  描述：

  3-溴-2-氯吡啶 、 L-氨基丙醇 以 吡啶 为溶剂， 反应 1.5h， 以84%的产率得到(S)-2-(3-bromopyridin-2-ylamino)propan-1-ol
  参考文献：
  名称：

  Microwave-assisted amination of 3-bromo-2-chloropyridine with various substituted aminoethanols

  摘要：

  A simple method for microwave-assisted amination of 3-bromo-2-chloropyridine with various substituted aminoethanols is described. The reaction was carried out under microwave irradiation conditions (at 180 degrees C for 1-2 h) and the result was superior in terms of conversion and yield when compared to that of the corresponding conventional heating conditions. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.05.021

文献信息

• Microwave-assisted amination of 3-bromo-2-chloropyridine with various substituted aminoethanols
  作者：Jeong Geun Kim、Eun Hae Yang、Woo Sup Youn、Ji Won Choi、Deok-Chan Ha、Jae Du Ha

  DOI：10.1016/j.tetlet.2010.05.021

  日期：2010.7

  A simple method for microwave-assisted amination of 3-bromo-2-chloropyridine with various substituted aminoethanols is described. The reaction was carried out under microwave irradiation conditions (at 180 degrees C for 1-2 h) and the result was superior in terms of conversion and yield when compared to that of the corresponding conventional heating conditions. (C) 2010 Elsevier Ltd. All rights reserved.