2',5'-bis-O-(tert-butyldimethylsilyl)-4-N-<2-<(tert-butyldiphenylsiloxy)methyl>benzoyl>cytidin-3'-yl 2',3'-bis-O-(tert-butyldimethylsilyl)uridin-5'-yl hydrogen phosphonate | 143344-22-3

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: 2',5'-bis-O-(tert-butyldimethylsilyl)-4-N-<2-<(tert-butyldiphenylsiloxy)methyl>benzoyl>cytidin-3'-yl 2',3'-bis-O-(tert-butyldimethylsilyl)uridin-5'-yl hydrogen phosphonate
• 英文别名: 2',5'-bis-O-(tert-butyldimethylsilyl)-4-N-{2-[(tert-butyldiphenylsiloxy)methyl]benzoyl}cytidin-3'-yl 2',3'-bis-O-(tert-butyldimethylsilyl)uridin-5'-yl hydrogen phosphonate
• CAS: 143344-22-3
• 化学式: C₆₆H₁₀₄N₅O₁₄PSi₅
• 分子量: 1362.98
• InChiKey: CZTCBTWHUQPELA-LAJLRAPBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  12.9
• 重原子数：
  91.0
• 可旋转键数：
  23.0
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  218.99
• 氢给体数：
  2.0
• 氢受体数：
  17.0

反应信息

• 作为反应物：
  描述：

  2',5'-bis-O-(tert-butyldimethylsilyl)-4-N-<2-<(tert-butyldiphenylsiloxy)methyl>benzoyl>cytidin-3'-yl 2',3'-bis-O-(tert-butyldimethylsilyl)uridin-5'-yl hydrogen phosphonate 在 四丁基氟化铵 、 sulfur 作用下， 以 四氢呋喃 、 吡啶 为溶剂， 反应 3.0h， 生成 cytidine-3'-yl uridin-5'-yl phosphorothioate
  参考文献：
  名称：

  Synthesis of diribonucleoside phosphorothioates via stereospecific sulfuration of H-phosphonate diesters

  摘要：

  Sulfurization of diribonucleoside H-phosphonates with elemental sulfur was found to be a stereospecific reaction. With this finding as the basis, an efficient method for the preparation of stereochemically homogeneous diribonucleoside phosphorothioates has been developed. The procedure consists of the synthesis and separation of the diastereomeric (R(p) and S(p)) pairs of the corresponding H-phosphonate diesters, followed by their stereospecific sulfurization and a single deprotection step using fluoride ion. The methodology has been used in synthesis of eight diribonucleoside phosphorothioates (four pairs of R(p) and S(p) diastereomers).

  DOI：

  10.1021/jo00049a022
• 作为产物：
  描述：

  叔丁基二甲基氯硅烷 在 吡啶 、 三甲基乙酰氯 、 silver nitrate 作用下， 以 四氢呋喃 、 吡啶 为溶剂， 生成 2',5'-bis-O-(tert-butyldimethylsilyl)-4-N-<2-<(tert-butyldiphenylsiloxy)methyl>benzoyl>cytidin-3'-yl 2',3'-bis-O-(tert-butyldimethylsilyl)uridin-5'-yl hydrogen phosphonate
  参考文献：
  名称：

  Synthesis of diribonucleoside phosphorothioates via stereospecific sulfuration of H-phosphonate diesters

  摘要：

  Sulfurization of diribonucleoside H-phosphonates with elemental sulfur was found to be a stereospecific reaction. With this finding as the basis, an efficient method for the preparation of stereochemically homogeneous diribonucleoside phosphorothioates has been developed. The procedure consists of the synthesis and separation of the diastereomeric (R(p) and S(p)) pairs of the corresponding H-phosphonate diesters, followed by their stereospecific sulfurization and a single deprotection step using fluoride ion. The methodology has been used in synthesis of eight diribonucleoside phosphorothioates (four pairs of R(p) and S(p) diastereomers).

  DOI：

  10.1021/jo00049a022