4-(isopropylamino)benzaldehyde | 27914-21-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 4-(isopropylamino)benzaldehyde
• 英文别名: 4-isopropylamino-benzaldehyde；4-Isopropylamino-benzaldehyd；4-methylethylaminobenzaldehyde；4-(propan-2-ylamino)benzaldehyde
• CAS: 27914-21-2
• 化学式: C₁₀H₁₃NO
• 分子量: 163.219
• InChiKey: FMWJFHMFGDMYAB-UHFFFAOYSA-N

物化性质

• 沸点：
  287.6±23.0 °C(Predicted)
• 密度：
  1.060±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-(isopropylamino)benzaldehyde 、 二乙基 3,5-二甲氧基苄基磷酸酯 在 sodium methylate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.5h， 以32%的产率得到(E)-4-(3,5-dimethoxystyryl)-N-isopropylaniline
  参考文献：
  名称：

  Design, synthesis, and evaluation of resveratrol derivatives as Aß1–42 aggregation inhibitors, antioxidants, and neuroprotective agents

  摘要：

  A series of novel resveratrol derivatives were designed, synthesised and evaluated as potential therapeutic agents for the treatment of Alzheimer's disease. Among these compounds, compound 7l, (E)-5-(4-(isopropylamino)styryl)benzene-1,3-diol, exhibited potent beta-amyloid aggregation inhibition activity, which was confirmed by a ThT fluorescence assay (71.65% at 20 mu M) and transmission electron microscopy (TEM). Compound 7l also exhibited good antioxidant activity (4.12 Trolox equivalents in an oxygen radical absorbance capacity assay and a 37% reduction in reactive oxygen species in cells at 10 mu M). The cytotoxicity analysis of compounds 7f, 7i, 7j and 7l indicated that these compounds have lower toxicities than resveratrol at 60 mu M. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.09.105
• 作为产物：
  描述：

  N-异丙基苯胺 生成 4-(isopropylamino)benzaldehyde
  参考文献：
  名称：

  Haddow et al., Philosophical Transactions of the Royal Society of London, 1948, vol. 241, p. 147,188

  摘要：

  DOI：

文献信息

• Method and apparatus for improving the oxidative thermal stability of distillate fuel
  申请人：Taylor Edwin Spencer

  公开号：US20050103686A1

  公开（公告）日：2005-05-19

  The present invention provides methods of improving the thermal oxidative stability of a distillate fuel which comprise selectively reducing the active concentration in the fuel of N—H containing heterocyclic aromatic compounds in which the nitrogen atom of the N—H group is part of the aromatic system, and wherein said fuel also contains an active concentration of metal compounds or will be exposed to active metal compounds in storage or in use. The present invention also provides methods of determining the thermal oxidative stability of a distillate fuel and apparatus for performing said methods.

  本发明提供了一种改善馏分燃料的热氧化稳定性的方法，其包括有选择地减少燃料中含有N-H杂环芳香化合物的活性浓度，其中N-H基团的氮原子是芳香系统的一部分，且该燃料还包含金属化合物的活性浓度或将在储存或使用中暴露于活性金属化合物。本发明还提供了一种确定馏分燃料的热氧化稳定性的方法和执行该方法的装置。
• 1,4-disubstituted piperidine derivatives and their use as 11,betahsd1 inhibitors
  申请人：Barton John Peter

  公开号：US20050256159A1

  公开（公告）日：2005-11-17

  A method for inhibiting 11βHSD1 by administering a compound of formula (I) is described, wherein A, X, Y, R 1 , R 12 , n, q, and m are as described in the specification. Novel compounds and methods employing them are also described and claimed.

  本发明涉及一种通过给予式(I)化合物来抑制11βHSD1的方法，其中A、X、Y、R1、R12、n、q和m如规范中所述。本发明还描述和声明了新的化合物和使用它们的方法。
• Cyclic Diguanylate G-Quadruplex Inducer-Nitric Oxide Donor Conjugate as a Bifunctional Antibiofilm Agent and Antibacterial Synergist against <i>Pseudomonas aeruginosa</i> with a Hyperbiofilm Phenotype
  作者：Qian-Wen Lin、Jin-Qiang Lu、Ye-Si Huang、Jie-Jiao Liu、Wei-Min Chen、Jing Lin

  DOI：10.1021/acs.jmedchem.3c00516

  日期：2023.9.14

  influence the level of cyclic diguanylate (c-di-GMP), a universal secondary messenger that plays an important role in biofilm formation in bacteria. Based on our previous finding that c-di-GMP G-quadruplex inducers are effective biofilm formation inhibitors, we designed and synthesized a c-di-GMP G-quadruplex inducer-NO donor conjugate (A11@NO) as a bifunctional antibiofilm agent after obtaining the c-di-GMP

  生物膜形成引起的抗生素耐药性是一个临床挑战。一氧化氮（NO）可以有效地分散成熟的生物膜，还可以协同影响环二鸟苷酸（c-di-GMP）的水平，环二鸟苷酸是一种通用的第二信使，在细菌生物膜的形成中发挥着重要作用。基于我们之前发现c-di-GMP G-四联体诱导剂是有效的生物膜形成抑制剂，我们设计并合成了c-di-GMP G-四联体诱导剂-NO供体缀合物（A11@NO）作为双功能抗生物膜剂。获得c-di-GMP G-四联体诱导剂( A11 )，其具有能够与亚硝基(NO供体)结合的氨基。缀合物A11@NO表现出比A11更好的生物膜抑制效率，并且还可以根除成熟的生物膜。此外，它对铜绿假单胞菌表现出良好的抗菌协同作用，有助于提高妥布霉素对生物膜形成细菌的杀菌效率。与妥布霉素联合使用，A11@NO还提高了秀丽隐杆线虫在超生物膜环境中的存活率。
• Preparation of amino acids from unsaturated hydantoins
  申请人：STAUFFER CHEMICAL COMPANY

  公开号：EP0177072A2

  公开（公告）日：1986-04-09

  Amino acids can be easily prepared by reducing unsaturated hydantoins to the corresponding saturated hydantoins by hydrogenating the unsaturated hydantoin using either Raney Nickel catalyst in the presence of more than a stoichiometric amount of caustic or by using zinc and hydrochloric acid followed by hydrolyzing the resultant composition with at least 3 molar equivalents of an alkali metal hydroxide to produce a racemate of an alpha amino acid. The amino acid in suitable derivative form can then be resolved particularly using a two-phase solvent system. The residual isomer of the amino acid remaining after the resolution process can then be racemized using either pyridoxal-5-phosphate or an aliphatic acid in combination with an aldehyde or a ketone. By these procedures, it is possible to obtain high yields of amino acids.

  通过使用雷尼镍催化剂在超过一定量的苛性碱存在下将不饱和海因氢化，或使用锌和盐酸将不饱和海因氢化，然后用至少 3 摩尔当量的碱金属氢氧化物水解所得到的组合物，生成α-氨基酸的外消旋体，从而将不饱和海因还原成相应的饱和海因，可以很容易地制备氨基酸。然后，以适当的衍生物形式存在的氨基酸可以通过两相溶剂系统进行溶解。然后，可使用吡哆醛-5-磷酸或脂肪族酸与醛或酮结合，对解析过程后残留的氨基酸异构体进行消旋化。通过这些程序，可以获得高产率的氨基酸。
• Promotion of raney nickel catalyst
  申请人：STAUFFER CHEMICAL COMPANY

  公开号：EP0210683A1

  公开（公告）日：1987-02-04

  There is disclosed a number of processes for the promotion of the Raney Nickel catalyzed hydrogenation of carbon-carbon double bonds. (a) One process uses tertiary amines to promote the Raney Nickel catalyzed hydrogenation. (b) Another process uses acetylene and acetylene derivatives to promote the Raney Nickel catalyzed hydrogenation. The promotion of Raney Nickel catalyst is particularly suited for the reduction of unsaturated hydantoins to saturated hydantoins and also for the reduction of cyclic and acyclic olefins and diolefins to the corresponding cyclic and acyclic alkanes.

  已公开了一些促进拉尼镍催化碳碳双键氢化的工艺。 (a) 一种工艺使用叔胺促进拉尼镍催化氢化。 (b) 另一种工艺使用乙炔和乙炔衍生物促进拉尼镍催化氢化。 拉尼镍催化剂的促进作用特别适用于将不饱和海因还原为饱和海因，也适用于将环状和非环状烯烃和二烯烃还原为相应的环状和非环状烷烃。