cholestene-(4)-diyl-(3β.6α)-diacetate | 3023-03-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: cholestene-(4)-diyl-(3β.6α)-diacetate
• 英文别名: (10R)-3c.6t-Diacetoxy-10r.13c-dimethyl-17c-((R)-1.5-dimethyl-hexyl)-(8cH.9tH.14tH)-Δ⁴-tetradecahydro-1H-cyclopenta[a]phenanthren；Cholesten-(4)-diyl-(3β.6α)-diacetat；3β.6α-Diacetoxy-cholesten-(4)；3β,6α-Diacetoxy-Δ⁴-cholesten；3β,6α-Diacetoxy-cholest-4-en；[(3S,6S,8S,9S,10R,13R,14S,17R)-6-acetyloxy-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,6,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate
• CAS: 3023-03-8
• 化学式: C₃₁H₅₀O₄
• 分子量: 486.736
• InChiKey: KFYYRJPCJHIFRL-CKLXOZIPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.4
• 重原子数：
  35
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.87
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  cholestene-(4)-diyl-(3β.6α)-diacetate 在 氢氧化钾 、 aluminum tri-tert-butoxide 、 丙酮 、 苯 作用下， 生成 (5alpha)-胆甾烷-3,6-二酮
  参考文献：
  名称：

  Technical efficiency of European railways: a distance function approach

  摘要：

  This study has two principal objectives. The first objective is to measure and compare the performance of European railways. The second objective is to illustrate the usefulness of econometric distance functions in the analysis of production in multi-output industries, where behavioural assumptions such as cost minimization or profit maximization, are unlikely to be applicable. Using annual data on 17 railways companies during 1988-1993, multioutput distance functions are estimated using corrected ordinary least squares (COLS). The resulting technical efficiency estimates range from 0.980 for the Netherlands to 0.784 for Italy, with a mean of 0.863. The distance function results are also compared with those obtained from single-output production functions, where aggregate output measures are formed using either total revenue or a Tornqvist index. The results obtained indicate substantial differences in parameter estimates and technical efficiency rankings, casting significant doubt upon the reliability of these single-output models, particularly when a total revenue measure is used to proxy aggregate output.

  DOI：

  10.1080/00036840050155896
• 作为产物：
  描述：

  3β-Hydroxycholestan-5α,6α-diol 在 吡啶 、 氯化亚砜 作用下， 生成 cholestene-(4)-diyl-(3β.6α)-diacetate
  参考文献：
  名称：

  Technical efficiency of European railways: a distance function approach

  摘要：

  This study has two principal objectives. The first objective is to measure and compare the performance of European railways. The second objective is to illustrate the usefulness of econometric distance functions in the analysis of production in multi-output industries, where behavioural assumptions such as cost minimization or profit maximization, are unlikely to be applicable. Using annual data on 17 railways companies during 1988-1993, multioutput distance functions are estimated using corrected ordinary least squares (COLS). The resulting technical efficiency estimates range from 0.980 for the Netherlands to 0.784 for Italy, with a mean of 0.863. The distance function results are also compared with those obtained from single-output production functions, where aggregate output measures are formed using either total revenue or a Tornqvist index. The results obtained indicate substantial differences in parameter estimates and technical efficiency rankings, casting significant doubt upon the reliability of these single-output models, particularly when a total revenue measure is used to proxy aggregate output.

  DOI：

  10.1080/00036840050155896

文献信息

• 19-nor-5β-Methyl-steroide, III. Die Acetolyse von 3-Methoxy-steroiden
  作者：Günther Snatzke

  DOI：10.1002/jlac.19656860120

  日期：1965.7.15

  y-Δ4-cholesten (III), 3β.6β-Diacetoxy-Δ4-cholesten (V) und dessen 3α-Epimeres (IVb) identifiziert werden. IV b und V entstehen durch Acetolyse aus dem 3β-Methoxy-Derivat III. Das 6-Monoacetat (VIc) des 5α-Cholestan-3α.5.6β-triols liefert mit SOCl2 ein cyclisches Sulfit VII, das 3-Monoacetat VId das entsprechende 5α.6α-Epoxyd IXb. Die Acetolyse gesättigter und ungesättigter 3β- und 3α-Methoxy-steroide

  的副产物3β甲氧基6β乙酰氧基5α胆甾-5-醇的重排威斯特法伦存在的（Ib）中可能是3β甲氧基6β乙酰氧基Δ的三个4 -cholesten（III），3β。 6β-二乙酰氧基Δ 4 -cholesten（V）和其3α差向异构体（IVb）中被识别。IV b和V通过3β-甲氧基衍生物III的乙酰化作用形成。5α-胆甾烷-3α.5.6β-三醇的6-单乙酸盐（VIc）为SOCl 2提供环状亚硫酸盐VII，3-单乙酸盐VId提供相应的5α.6α-环氧化物IXb。KHSO 4或SnCl 4对饱和和不饱和3β-和3α-甲氧基类固醇的乙酰化作用在相同条件下，在乙酸酐中加入3，3-乙氧基化合物和甲醇消除产物的量各不相同，而胆固醇甲醚在相同条件下仅产生胆固醇乙酸酯。3β-甲氧基-19-的反应也不-5β甲基Δ 9 -cholesten-6β醇（IIa）中进行了描述。
• Studies on stereocontrolled epoxidations of bis-alicyclic alcohols in steroidal skeletons: preparation of eight diastereomerically pure epoxides from cholest-4-en-3β,6β-; -3β,6α-; -3α,6β- and -3α,6α-diols
  作者：Kejun Zhao、Yongfeng Wang、David C. Billington

  DOI：10.1016/s0957-4166(01)00174-4

  日期：2001.5

  Eight diastereomerically pure epoxides have been prepared from cholest-4-en-3β,6β; -3β,6α-; -3α,6β- and -3α,6α-diols via a combination of steric, protecting group and oxidant effects on stereocontrolled epoxidations of a bis-alicyclic alcohol system within the steroidal skeleton.

  从cholest-4-en-3β，6β制备了八种非对映体纯的环氧化物；-3β，6α-; -3α，6β-和-3α，6α-二醇通过空间，保护基和氧化剂的组合作用对甾体骨架内双脂环式醇系统的立体控制的环氧化作用。
• Willingness to pay for publicly-financed health care: how should we use the numbers?
  作者：Phil Shackley、Cam Donaldson

  DOI：10.1080/00036840050155940

  日期：2000.12.1

  This paper addresses the question of how willingness to pay (WTP) values in health care evaluation can be used by policy makers. The way in which WTP values are used depends on from whom values are elicited and whether the good concerned is privately-financed or publicly-financed through taxation. Thus, four possible uses of WTP values are identified. The focus is on the two uses which arise in the publicly-financed situation. 'Conventional' use of WTP values, where the decision as to whether or not to provide a service depends upon whether or not WTP values are greater than total cost, applies only in the privately-financed, and not publicly-financed situations. The situations with publicly-financed goods are more complex. The use of WTP values for publicly-financed goods is justified and illustrated.
• 627. Steroids and related compounds. Part VII. Some derivatives of 5-methyl-10-norandrost-8(9)-ene-3 : 6-diol-17-one
  作者：M. Davis、V. Petrow

  DOI：10.1039/jr9490002973

  日期：——
• Acid catalysed rearrangements of some 5α-acertoxy steroids
  作者：J.M. Coxon、M.P. Hartshorn、G.A. Lane、K.E. Richards、U.M. Senanayake

  DOI：10.1016/s0039-128x(69)80006-1

  日期：1969.10