dicholesteryl sulfite | 50736-01-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: dicholesteryl sulfite
• 英文别名: Schwefligsaeure-dicholesterylester；Dicholesteryl-sulfit；bis[(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] sulfite
• CAS: 50736-01-1
• 化学式: C₅₄H₉₀O₃S
• 分子量: 819.373
• InChiKey: HLGNAFRHPNDEGO-MALNHOFLSA-N

物化性质

• 熔点：
  185-186 °C
• 沸点：
  784.8±40.0 °C(Predicted)
• 密度：
  1.06±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  18.2
• 重原子数：
  58
• 可旋转键数：
  14
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  54.7
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  dicholesteryl sulfite 在 乙醚 、 溴 、 溶剂黄146 作用下， 生成 sulfurous acid bis-(5,6β-dibromo-5α-cholestanyl-(3β)-ester)
  参考文献：
  名称：

  Equine respiratory viruses in foals in New Zealand

  摘要：

  AIMS: To identify the respiratory viruses that are present among foals in New Zealand and to establish the age at which foals first become infected with these viruses.METHODS: Foals were recruited to the study in October/ November 1995 at the age of 1 month (Group A) or in March/ April 1996 at the age of 4-6 months (Groups B and C). Nasal swabs and blood samples were collected at monthly intervals. Nasal swabs and peripheral blood leucocytes (PBL) harvested from heparinised blood samples were used for virus isolation; serum harvested from whole-blood samples was used for serological testing for the presence of antibodies against equine herpesvirus (EHV)-1 or -4, equine rhinitis-A virus (ERAV), equine rhinitis-B virus (ERBV), equine adenovirus 1 (EAdV-1), equine arteritis virus (EAV), reovirus 3 and parainfluenza virus type 3 (PIV3). Twelve foals were sampled until December 1996; the remaining 19 foals were lost from the study at various times prior to this date.RESULTS: The only viruses isolated were EHV 2 and EHV 5. EHV 2 was isolated from 155/157 PBL samples collected during the period of study and from 40/172 nasal swabs collected from 18 foals. All isolations from nasal swabs, except one, were made over a period of 2-4 months from January to April (Group A), March to April (Group B) or May, to July (Group C). EHV 5 was isolated from either PBL, nasal swabs, or both, from 15 foals on 32 occasions. All foals were positive for antibodies to EHV 1 or EHV 4, as tested by serum neutralisation (SN), on at least one sampling occasion and all but one were positive for EHV 1 antibodies measured by enzyme-linked immunosorbent assay (ELISA) on at least one sampling occasion. Recent EHV 1 infection was evident at least once during the period of study in 18/23 (78%) foals for which at least two samples were collected. SN antibodies to ERBV were evident in 19/23 (83%) foals on at least one sampling occasion and 15/23 foals showed evidence of seroconversion to ERBV Antibodies to ERAV were only detected in serum samples collected from foals in Group A and probably represented maternally-derived antibodies. Haemagglutination inhibition (HI) antibody titres greater than or equal to 1:10 to EAdV-1 were evident in 21/23 (91%) foals on at least one sampling occasion and 16/23 foals showed serological evidence of recent EAdV-1 infection. None of the 67 serum samples tested were positive for antibodies to EAV, reovirus 3 or PIV3. There was no clear association between infection with any of the viruses isolated or tested for and the presence of overt clinical signs of respiratory disease.CONCLUSIONS: There was serological and/or virological evidence that EHV-1, EHV-2, EHV-5, EAdV-1 and ERBV infections were present among foals in New Zealand. EHV-2 infection was first detected in foals as young as 3 months of age. The isolation of EHV-2 from nasal swabs preceded serological evidence of infection with other respiratory viruses, suggesting that EHV-2 may predispose foals to other viral infections.

  DOI：

  10.1080/00480169.2002.36300
• 作为产物：
  描述：

  cholesterol 在 吡啶 、 氯化亚砜 、 苯 作用下， 生成 dicholesteryl sulfite
  参考文献：
  名称：

  Kitasato; Sone, Chemische Berichte, 1931, vol. 64, p. 1142,1145

  摘要：

  DOI：

文献信息

• THE ACTION OF THIONYL CHLORIDE UPON CHOLESTEROL AND CERTAIN OTHER ALCOHOLS¹
  作者：Paul J. Daughenbaugh、James B. Allison

  DOI：10.1021/ja01387a031

  日期：1929.12
• Daeumer,E., Diss. <Halle 1912> S. 20
  作者：Daeumer,E.

  DOI：——

  日期：——
• US5225330A
  申请人：——

  公开号：US5225330A

  公开（公告）日：1993-07-06