N-(Trimethylsilyl)-4-(trimethylsiloxy)benzolamin | 52726-86-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(Trimethylsilyl)-4-(trimethylsiloxy)benzolamin
• 英文别名: bis(trimethylsilyl) derivative of 4-aminophenol；N,O-bistrimethylsilyl-p-aminophenol；O,N-bis-(trimethylsilyl)-4-aminophenol；p-(Trimethylsilyloxy)-N-(trimethylsilyl)-anilin；N,O-Bis(trimethylsilyl)-p-aminophenol；Silanamine, 1,1,1-trimethyl-N-[4-[(trimethylsilyl)oxy]phenyl]-；N-trimethylsilyl-4-trimethylsilyloxyaniline
• CAS: 52726-86-0
• 化学式: C₁₂H₂₃NOSi₂
• 分子量: 253.492
• InChiKey: AKOKOVKFSOYFHK-UHFFFAOYSA-N

物化性质

• 沸点：
  270 °C
• 密度：
  0.9448 g/cm3
• 保留指数：
  1528.1

计算性质

• 辛醇/水分配系数(LogP)：
  4.15
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-(Trimethylsilyl)-4-(trimethylsiloxy)benzolamin 在 三甲基氯硅烷 、 三乙胺 作用下， 以 甲苯 为溶剂， 反应 8.5h， 生成 4-(4-Hydroxyphenyl)-1,2,4-triazolidin-3,5-dion
  参考文献：
  名称：

  Burgert, Josef; Stadler, Reimund, Chemische Berichte, 1987, vol. 120, p. 691 - 694

  摘要：

  DOI：
• 作为产物：
  描述：

  对氨基苯酚 、 三甲基硅烷基二乙胺 反应 3.0h， 以90%的产率得到N-(Trimethylsilyl)-4-(trimethylsiloxy)benzolamin
  参考文献：
  名称：

  Kozyukov, V. P.; Mironova, N. V., Journal of general chemistry of the USSR, 1980, vol. 50, # 3, p. 504 - 509

  摘要：

  DOI：

文献信息

• A simple and efficient room temperature silylation of diverse functional groups with hexamethyldisilazane using CeO2 nanoparticles as solid catalysts
  作者：Nagaraj Anbu、Chellappa Vijayan、Amarajothi Dhakshinamoorthy

  DOI：10.1016/j.mcat.2019.03.015

  日期：2019.9

  In this study, a mild and efficient method is developed for the silylation of diverse functional groups using CeO2 nanoparticles (n-CeO2) as solid catalysts with hexamethyldisilazane (HMDS) as silylating agent at room temperature. Alcohols, phenols and acids are silylated to their respective silyl derivatives with faster reaction rate while amines and thiols required relatively longer reaction time

  在这项研究中，开发了一种温和而有效的方法，用于使用CeO 2纳米颗粒（n-CeO 2）作为固体催化剂，在室温下以六甲基二硅氮烷（HMDS）作为甲硅烷基化剂。醇，酚和酸以更快的反应速率被甲硅烷基化为它们各自的甲硅烷基衍生物，而胺和硫醇则需要相对较长的反应时间。而且，固体催化剂易于从反应混合物中分离并循环使用五次以上，而其活性没有任何明显的下降。粉末X射线衍射（XRD），透射电子显微镜（TEM），紫外可见漫反射光谱（UV-DRS）和拉曼分析显示，与再利用的固体相比，重复使用的固体具有相同的结构完整性，粒径，吸收边缘和化合价态。新鲜的固体催化剂。
• 7-aryl-6(Z)-heptatrienoic acid retinamides
  申请人：Hoffmann-LA Roche Inc.

  公开号：US06310247B1

  公开（公告）日：2001-10-30

  Novel trienoic retinoid compounds of with apoptotic activity useful for the prevention and treatment of cancer.

  具有凋亡活性的新型三烯醇类维生素A化合物，可用于预防和治疗癌症。
• Calverley, Martin J., Synthetic Communications, 1983, vol. 13, # 7, p. 601 - 610
  作者：Calverley, Martin J.

  DOI：——

  日期：——
• A study of ortho- and para-siloxyanilines for the synthesis of mono-, bi-, and tetra-nuclear early transition metal–imido complexes
  作者：J.M Benito、Silvia Arévalo、E de Jesús*、F.J de la Mata、J.C Flores*、R Gómez

  DOI：10.1016/s0022-328x(00)00391-0

  日期：2000.9

  The siloxyanilines o-Me(3)SiOC(6)H(4)NH(2) (1) and p-RMe(2)SiOC(6)H(4)NH(2) (R = H (2); R = Me (3)), and their N-silylated derivatives p-Me(3)SiOC(6)H(4)NHSiMe(3) (4) and p-Me(3)SiOC(6)H(4)N(SiMe(3))(2) (5) have been prepared from ortho- or para-aminophenol and used in the synthesis of imido complexes. Thus, binuclear [Ti(eta (5)-C(5)H(5))Cl} mu -NC(6)H(4)(p-OSiMe(3))}](2) (6) and mononuclear [TiCl(2)NC(6)H(4)(p-OSiMe(3))}(py)(3)] (7) imido complexes have been obtained from the reaction of 3 and [Ti(eta (5)-C(5)H(5))Cl(3)] or [TiCl(2)(N'Bu)(py)(3)], respectively. In contrast, the reaction of 1 with TiCl(4) and 'Bupy affords the titanocycle [TiCl(2)OC(6)H(4)(o-NH)-N,O}('Bupy)(2)] (8). Compound 5 has also been used to prepare the niobium imide complex [NbCl(3)NC(6)H(4)(p-OSiMe(3))}(MeCN)(2)] (9), by its reaction with NbCl(5) in CH(3)CN. These findings have been applied to the synthesis of polynuclear systems. Thus, chlorocarbosilane Si[CH(2)CH(2)CH(2)Si(Me)(2)Cl], (CS-Cl) has been functionalized with the ortho- and para-aminophenoxy groups to give 10 and 11, respectively. The use of 11 has allowed the formation of the tetranuclear compound 12. Attempts to synthesize terminal imido titanium complexes from 10 and TiCl(4) in the presence of 'Bupy and Et(3)N, give complex 8 and carbosilane CS-Cl. (C) 2000 Elsevier Science S.A. All rights reserved.
• Cyclodextrins in Polymer Chemistry:  Enzymatically Catalyzed Oxidative Polymerization of Para-Functionalized Phenol Derivatives in Aqueous Medium by Use of Horseradish Peroxidase
  作者：Yanjie Pang、Helmut Ritter、Monir Tabatabai

  DOI：10.1021/ma021678x

  日期：2003.9.1

  Ethyl 1-[(4-hydroxyphenyl)aminocarbonyl)]-2-vinylcyclopropane carboxylate has been oligomerized using horseradisch peroxidase as catalyst. The oligomerization was achieved in the presence of cyclodextrine at room temperature in phosphate buffer (pH 7). The oligomer formed was cross-linked via free radical polymerization.