methyl p-nitrophenyl phosphorochloridothionate | 96790-19-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: methyl p-nitrophenyl phosphorochloridothionate
• 英文别名: Chloro-methoxy-(4-nitrophenoxy)-sulfanylidene-lambda5-phosphane；chloro-methoxy-(4-nitrophenoxy)-sulfanylidene-λ5-phosphane
• CAS: 96790-19-1
• 化学式: C₇H₇ClNO₄PS
• 分子量: 267.63
• InChiKey: NPQGIDCAFMILNP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  96.4
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  methyl p-nitrophenyl phosphorochloridothionate 、 4-氨基丁酸 在 potassium hydroxide 作用下， 以 甲醇 为溶剂， 反应 0.08h， 生成
  参考文献：
  名称：

  Agent orange herbicides, organophosphate and triazinic pesticides analysis in olive oil and industrial oil mill waste effluents using new organic phase immunosensors

  摘要：

  New immunosensors working in organic solvent mixtures (OPIEs) for the analysis of traces of different pesticides (triazinic, organophosphates and chlorurates) present in hydrophobic matrices such as olive oil were developed and tested. A Clark electrode was used as transducer and peroxidase enzyme as marker. The competitive process took place in a chloroform-hexane 50% (V/V) mixture, while the subsequent enzymatic final measurement was performed in decane and using tert-butylhydroperoxide as substrate of the enzymatic reaction. A linear response of between about 10 nM and 5.0 mu M was usually obtained in the presence of olive oil. Recovery tests were carried out in commercial or artisanal extra virgin olive oil. Traces of pesticides were also checked in the oily matrix, in pomace and mill wastewaters from an industrial oil mill. Immunosensors show good selectivity and satisfactory precision and recovery tests performed in olive oil gave excellent results. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.foodchem.2014.07.137
• 作为产物：
  描述：

  去甲基-甲基对硫磷 在 五氯化磷 作用下， 以 氯仿 为溶剂， 反应 2.0h， 以90%的产率得到methyl p-nitrophenyl phosphorochloridothionate
  参考文献：
  名称：

  的两种对映体的立体选择性合成P -chirogenic 2-氧代-2-硫代-1,3,2- oxazaphosphorinane四甲基铵盐作为关键前体在结构上不同的手性衍生物

  摘要：

  2-氧代-2-硫代-1,3,2- oxazaphosphorinanyl盐的两种对映体的完全立体选择性合成已在五个步骤而完成的具有总体40-45％的产率从非对映异构起始Ñ甲基-methylstrychninium盐p -硝基苯基硫代磷酸。将其转化为对氯苯基硫代氯代磷酸对硝基苯基酯的两步磷酸化剂的对映体形式，可以在该反应序列中形成1,3,2-氧杂氮杂正膦环。开发了对映纯标题盐的另一种四步方法，该方法涉及第一步和关键步骤是硫代磷酰氯与N之间的环缩合含有1，3-氨基丙醇基的-α-萘乙基几乎完全具有非对映选择性。

  DOI：

  10.1016/j.tet.2011.10.085

文献信息

• 甲基对硫磷半抗原及其制备方法和应用
  申请人：北京勤邦生物技术有限公司

  公开号：CN103288872B

  公开（公告）日：2016-07-27

  本发明公开了一种半抗原及其制备方法和应用，具体涉及一种甲基对硫磷半抗原。本发明还公开了所述半抗原的制备方法及其应用。基于甲基对硫磷半抗原建立的试剂盒快速检测产品，使用方便、检测成本低、检测方法高效、准确、快速、可同时检测大批量的样本，适用于玉米、苹果样本中甲基对硫磷残留的现场监控和大量样本的筛查。
• Shao-Yong, Wu; Eto, Morifusa, Agricultural and Biological Chemistry, 1984, vol. 48, # 12, p. 3071 - 3080
  作者：Shao-Yong, Wu、Eto, Morifusa

  DOI：——

  日期：——
• Hirashima, Akinori; Eto, Morifusa, Agricultural and Biological Chemistry, 1983, vol. 47, # 12, p. 2831 - 2840
  作者：Hirashima, Akinori、Eto, Morifusa

  DOI：——

  日期：——
• Agent orange herbicides, organophosphate and triazinic pesticides analysis in olive oil and industrial oil mill waste effluents using new organic phase immunosensors
  作者：Elisabetta Martini、Giovanni Merola、Mauro Tomassetti、Luigi Campanella

  DOI：10.1016/j.foodchem.2014.07.137

  日期：2015.2

  New immunosensors working in organic solvent mixtures (OPIEs) for the analysis of traces of different pesticides (triazinic, organophosphates and chlorurates) present in hydrophobic matrices such as olive oil were developed and tested. A Clark electrode was used as transducer and peroxidase enzyme as marker. The competitive process took place in a chloroform-hexane 50% (V/V) mixture, while the subsequent enzymatic final measurement was performed in decane and using tert-butylhydroperoxide as substrate of the enzymatic reaction. A linear response of between about 10 nM and 5.0 mu M was usually obtained in the presence of olive oil. Recovery tests were carried out in commercial or artisanal extra virgin olive oil. Traces of pesticides were also checked in the oily matrix, in pomace and mill wastewaters from an industrial oil mill. Immunosensors show good selectivity and satisfactory precision and recovery tests performed in olive oil gave excellent results. (C) 2014 Elsevier Ltd. All rights reserved.
• Stereoselective synthesis of both enantiomers of P-chirogenic 2-oxo-2-thio-1,3,2-oxazaphosphorinane tetramethylammonium salt as key precursors to structurally diverse chiral derivatives
  作者：Marian Mikołajczyk、Jerzy Łuczak、Lesław Sieroń、Michał W. Wieczorek

  DOI：10.1016/j.tet.2011.10.085

  日期：2012.1

  A fully stereoselective synthesis of both enantiomers of 2-oxo-2-thio-1,3,2-oxazaphosphorinanyl salt has been accomplished in five steps with an overall 40–45% yield starting from the diastereoisomeric N-methylstrychninium salts of methyl p-nitrophenyl phosphorothioic acid. Their conversion to the enantiomeric forms of methyl p-nitrophenyl phosphorochloridothionate as a two-step phosphorylating agent

  2-氧代-2-硫代-1,3,2- oxazaphosphorinanyl盐的两种对映体的完全立体选择性合成已在五个步骤而完成的具有总体40-45％的产率从非对映异构起始Ñ甲基-methylstrychninium盐p -硝基苯基硫代磷酸。将其转化为对氯苯基硫代氯代磷酸对硝基苯基酯的两步磷酸化剂的对映体形式，可以在该反应序列中形成1,3,2-氧杂氮杂正膦环。开发了对映纯标题盐的另一种四步方法，该方法涉及第一步和关键步骤是硫代磷酰氯与N之间的环缩合含有1，3-氨基丙醇基的-α-萘乙基几乎完全具有非对映选择性。