3-(m-methylphenoxy)propan-1-ol | 13030-21-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 3-(m-methylphenoxy)propan-1-ol
• 英文别名: <3-Hydroxy-propyl>-<3-methyl-phenyl>-ether；3-(m-Methylphenoxy)propylalkohol；γ-m-cresyloxy-propyl alcohol；(γ-Oxy-propyl)-m-tolyl-aether；Trimethylenglykol-mono-m-tolylaether；γ-m-Kresoxy-propylalkohol；3-(m-cresoxy)-propanol；3-(3-Methylphenoxy)propan-1-ol
• CAS: 13030-21-2
• 化学式: C₁₀H₁₄O₂
• 分子量: 166.22
• InChiKey: VJTWRCVKEPMXKN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-(m-methylphenoxy)propan-1-ol 在 permanganate(VII) ion 、 magnesium sulfate 作用下， 生成 3-间甲苯氧基丙酸
  参考文献：
  名称：

  Powell; Johnson, Journal of the American Chemical Society, 1924, vol. 46, p. 2863

  摘要：

  DOI：
• 作为产物：
  描述：

  间甲酚 、 1,3-丙二醇 在 dialkyl azodicarboxylate 、 三苯基膦 作用下， 以 四氢呋喃 为溶剂， 以87.5%的产率得到3-(m-methylphenoxy)propan-1-ol
  参考文献：
  名称：

  Entropy-Controlled Asymmetric Synthesis. How Differential Activation Entropy Is Induced in Chiral Tethered Reactions

  摘要：

  [GRAPHICS]Kinetic measurements to determine effective molarities of intramolecular reactions using 2,4-pentanediol and related tethers showed that methyl groups on the tether accelerate the major diastereomeric process but decelerate the minor process. The efficient promotion of stereocontrol is suggested to be due to chiral perturbation of the reaction rate through the entropy term, The conformation of the encounter complex of the reagent and reactant moieties was deduced by stereochemical analysis of the intramolecular adducts.

  DOI：

  10.1021/ol006741m

文献信息

• [EN] VEGFR TYROSINE KINASE INHIBITORS<br/>[FR] INHIBITEURS DE TYROSINE KINASE VEGFR
  申请人：SUZHOU VIVOTIDE BIOTECHNOLOGIES CO LTD

  公开号：WO2014183300A1

  公开（公告）日：2014-11-20

  Novel compounds, their prodrugs, and the pharmaceutically acceptable salts as pharmaceutical compositions containing such compounds useful in treating certain diseases modulated by the inhibition of vascular endothelial growth factors (VEGFs) receptor tyrosine kinases are provided. In particular, compounds and compositions and the methods for the prophylaxis, management and treatment of cancers through the inhibition of VEGF receptor tyrosine kinases are provided.

  提供了作为含有这些化合物的药物组合物的前药和药用盐，用于治疗受血管内皮生长因子（VEGFs）受体酪氨酸激酶抑制调节的特定疾病。具体提供了通过抑制VEGF受体酪氨酸激酶来预防、管理和治疗癌症的化合物、组合物和方法。
• New Oxidative Aromatization of α,β-Unsaturated Cyclohexenones with Iodine–Cerium(IV) Ammonium Nitrate in Alcohol
  作者：C. Akira Horiuchi、Hirotada Fukunishi、Mika Kajita、Akihisa Yamaguchi、Hiroshi Kiyomiya、Shinji Kiji

  DOI：10.1246/cl.1991.1921

  日期：1991.11

  (methanol, ethanol, 1-propanol, 2-propanol, and 1-butanol) under refluxing, gave the corresponding alkyl phenyl ethers in good yields. In the case of diol (ethylene glycol, 1,3-propanediol, and 1,4-butanediol), phenoxyalkanol derivatives were obtained. The present method was also applicable to oxidative rearrangement of isophorone.

  2-环己烯-1-酮衍生物与碘-铈（IV）硝酸铵在醇（甲醇、乙醇、1-丙醇、2-丙醇和1-丁醇）中回流反应，得到相应的烷基苯基醚良好的收益。在二醇（乙二醇、1,3-丙二醇和1,4-丁二醇）的情况下，获得苯氧基链烷醇衍生物。本方法也适用于异佛尔酮的氧化重排。
• Dye mixtures of anthraquinone dyes
  申请人：Ciba Geigy Corporation

  公开号：US04510088A1

  公开（公告）日：1985-04-09

  Dye mixtures containing at least two dyes of the formula (1) ##STR1## wherein R is hydrogen, methyl or ethyl, and n is an integer from 2 to 4, exhibit on synthetic textile material a build-up which is considerably better than that of the individual dyes.

  含有至少两种化学式（1）中的染料的染料混合物##STR1##其中R为氢、甲基或乙基，n为2到4的整数，在合成纺织材料上表现出比单个染料更好得多的染色效果。
• METHOD FOR PRODUCING FLUORENE DERIVATIVE
  申请人：Fujii Katsuhiro

  公开号：US20120029244A1

  公开（公告）日：2012-02-02

  A method for producing a fluorene derivative by reacting fluorenone with a phenol or a phenoxyalcohol in the presence of an acid catalyst includes: adding an alkali to an obtained reaction liquid containing a fluorene derivative; and concentrating a resultant mixture liquid without removing the alkali thus added and a reaction product of the alkali, thereby separating an unreacted phenol or unreacted phenoxyalcohol.

  一种制备芴衍生物的方法，通过在酸催化剂存在下将芴酮与苯酚或苯氧乙醇反应，包括以下步骤：向含有芴衍生物的反应液中加入碱；在不去除已添加的碱和碱的反应产物的情况下浓缩混合液，从而分离未反应的苯酚或未反应的苯氧乙醇。
• Pesticidal heterocycles
  申请人：Dixson A. John

  公开号：US20050143418A1

  公开（公告）日：2005-06-30

  It has now been found that certain novel heterocyclic derivatives have provided unexpected insecticidal activity. These compounds are represented by formula (I): R Preferred are those compounds of formula (I) where R 2 and R3 taken together is ═NCH(R 6 )CH(R 7 )N(R 8 )—, ═NC(R6)═C(R7)N(R8)—, or ═CHN═C(R 7 )N(R 8 )—, and tautomers thereof, and where R 4 and R 5 taken together is —C(R11)═C(R12)C(R13)═C(R14) 1 12, —, where R,R,R 6, R 7, R8, R I1, R R 13, R 14, and X are described. In addition, compositions comprising an insecticidally effective amount of at least one compound of formula (I), and optionally, an effective amount of at least one of a second compound, with at least one insecticidally compatible carrier are also disclosed; along with methods of controlling insects comprising applying said compositions to a locus where insects are present or are expected to be present.

  现已发现某些新型杂环衍生物提供了意外的杀虫活性。这些化合物由式（I）表示：R。其中，首选的是式（I）中R2和R3结合起来为═NCH（R6）CH（R7）N（R8）—，═NC（R6）═C（R7）N（R8）—或═CHN═C（R7）N（R8）—及其互变异构体，并且其中R4和R5结合起来为—C（R11）═C（R12）C（R13）═C（R14）1 12,—，其中描述了R、R2、R3、R6、R7、R8、R11、R12、R13、R14和X。此外，还公开了包含式（I）中至少一种化合物的杀虫有效量和可选的第二种化合物的有效量，以及至少一种杀虫兼容载体的组合物；以及控制昆虫的方法，包括将所述组合物应用于昆虫存在或预计存在的地点。