1,3-Propandiolbis(acetylsalicylat) | 19283-97-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1,3-Propandiolbis(acetylsalicylat)
• 英文别名: 1,3-propanediol bis-acetylsalicylate；3-(2-Acetyloxybenzoyl)oxypropyl 2-acetyloxybenzoate
• CAS: 19283-97-7
• 化学式: C₂₁H₂₀O₈
• 分子量: 400.385
• InChiKey: HAOFYQRIYUWUOD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  29
• 可旋转键数：
  12
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  105
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  1,3-二溴丙烷 、 阿司匹林 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 1,3-Propandiolbis(acetylsalicylat)
  参考文献：
  名称：

  Synthesis and in vitro evaluation of triphenylphosphonium derivatives of acetylsalicylic and salicylic acids: structure-dependent interactions with cancer cells, bacteria, and mitochondria

  摘要：

  DOI：

  10.1007/s00044-020-02674-6

文献信息

• Process for the preparation of a pharmacologically active chemical combination
  申请人：Laboratori Alchemica S.r.l.

  公开号：US06369260B1

  公开（公告）日：2002-04-09

  Process for the preparation of a pharmacologically active chemical combination constituted by the association, through chemical bonds, of units equal to one another, having each an own pharmacological activity, and with the general formula (I): M—A—X—B—M, where M indicates said unit having an own pharmacological activity, X indicates a “bidentate” structure suitable to interconnect the M units, A and B indicate functional groups either equal to or different from one another which allow the interconnection between M and X.

  制备一种药物活性化学组合物的过程，该组合物通过化学键连接相等单元构成，每个单元均具有自身的药理活性，并具有通用公式(I)：M—A—X—B—M，其中M表示具有自身药理活性的单元，X表示适合于相互连接M单元的“双齿”结构，A和B表示相等或不同的功能团，它们允许M和X之间的相互连接。
• PROCESS FOR PRODUCING CELLULOSE ESTER FILM, CELLULOSE ESTER FILM, POLARIZATION PLATE AND DISPLAY UNIT
  申请人：Kawabe Satomi

  公开号：US20090306361A1

  公开（公告）日：2009-12-10

  A process for producing a cellulose ester film that is produced by a melt casting method using no solvent at film formation, and that attains reduction of bright spot foreign matter, excelling in planarity, and that attains reduction of staining, excelling in dimensional stability. It is also intended to provide such a cellulose ester film, a polarizing plate and a liquid crystal display unit. There is provided a process for producing a cellulose ester film, characterized by forming into a film a material containing a cellulose ester and an ester compound of 1 to 7.5 distribution coefficient obtained by condensation of a polyhydric alcohol and an organic acid of the general formula: (1) according to a melt casting method.
• METHOD OF PRODUCING CELLULOSE ESTER FILM, CELLULOSE ESTER FILM, POLARIZING PLATE AND LIQUID CRYSTAL DISPLAY
  申请人：Kawabe Satomi

  公开号：US20100151156A1

  公开（公告）日：2010-06-17

  Disclosed is a method for producing a cellulose ester film wherein a film-forming material containing the following components A-C is heated and melted, and a cellulose ester film is formed therefrom by melt-casting. A: a cellulose resin, B: an ester compound obtained by condensing an organic acid represented by Formula (1) and a polyalcohol, and C: an aliphatic polyester or an aliphatic-aromatic copolymer.
• US8246880B2
  申请人：——

  公开号：US8246880B2

  公开（公告）日：2012-08-21
• Synthesis and in vitro evaluation of triphenylphosphonium derivatives of acetylsalicylic and salicylic acids: structure-dependent interactions with cancer cells, bacteria, and mitochondria
  作者：Olga V. Tsepaeva、Taliya I. Salikhova、Leysan R. Grigor’eva、Denis V. Ponomaryov、Trinh Dang、Rezeda A. Ishkaeva、Timur I. Abdullin、Andrey V. Nemtarev、Vladimir F. Mironov

  DOI：10.1007/s00044-020-02674-6

  日期：2021.4