Cp2Ti(P(OEt)3)2 | 185991-38-2

• 分子结构分类: 有机化合物 - 有机磷化合物 - 有机膦及其衍生物
• 英文名称: Cp2Ti(P(OEt)3)2
• 英文别名: cyclopenta-1,3-diene;titanium(2+);triethyl phosphite
• CAS: 185991-38-2
• 化学式: C₂₂H₄₀O₆P₂Ti
• 分子量: 510.384
• InChiKey: BNQISBFBNVTOKF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  Cp2Ti(P(OEt)3)2 、 tetrakis[bis(phenylthio)methyl]germane 以 四氢呋喃 为溶剂， 以75%的产率得到2,2,6,6-tetrakis(η5-cyclopentadienyl)-1,3,5,7-tetrakis(phenylthio)-4-germa-2,6-dititanaspiro[3.3]heptane
  参考文献：
  名称：

  Stereoselective formation of phenylthio groups substituted 1-metalla-3-titanacyclobutanes

  摘要：

  Desulfurizative titanation of group 14 metal compounds bearing two or four bis(phenylthio)methyl groups with the low-valent titanium reagent Cp2Ti[P(OEt)(3)](2) produced phenylthio groups substituted 1-metalla-3-titanacyclobutanes stereoselectively. The molecular structures of the titanacycles were unambiguously confirmed by X-ray diffraction analysis. (c) 2010 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jorganchem.2010.09.080
• 作为产物：
  描述：

  二氯二茂钛 、 亚磷酸三乙酯 在 magnesium 作用下， 以 四氢呋喃 为溶剂， 25.0 ℃ 、399.97 Pa 条件下， 反应 3.0h， 生成 Cp2Ti(P(OEt)3)2
  参考文献：
  名称：

  利用甲硅烷基取代的钛卡宾配合物作为双金属合成试剂的共轭二烯和烯基环丙烷的多样性取向合成

  摘要：

  研究了使用甲硅烷基取代的钛卡宾配合物的顺序反应，以多样性为导向的共轭二烯和链烯基环丙烷的合成方法。二烯基硅烷是通过将羰基化合物与γ-甲硅烷基乙烯基卡宾配合物进行烯化而制得的。用乙烯基碳烯络合物对1-烯烃进行环丙烷化可生成具有高立体选择性的（E）-（β-甲硅烷基乙烯基）环丙烷。β-（三烷基甲硅烷基）卡宾络合物与高炔丙醇的烷氧基锌反应生成具有高区域和立体选择性的6-甲硅烷基-3,5-己二-1-醇。通过钯催化的或铜（I）促进的与有机卤化物的交叉偶联，将如此获得的（E）-烯基硅烷转化为一系列不饱和化合物，并保留了构型。

  DOI：

  10.1016/j.tet.2014.06.043
• 作为试剂：
  描述：

  [5-Chloro-4-(chloromethyl)hexyl]benzene 在 Cp2Ti(P(OEt)3)2 作用下， 以 四氢呋喃 为溶剂， 反应 3.0h， 生成 4-methyl-1-phenylhexane 、 3-(2-methylcyclopropyl)propylbenzene 、 3-(2-methylcyclopropyl)propylbenzene
  参考文献：
  名称：

  Formation of Cyclopropanes by the Reductive Coupling of 1,3-Dihalides Promoted by Titanocene(II) Species

  摘要：

  各种含酯基的1,3-二卤化物及其他1,3-二卤化物的处理方法与二茂钛(II)物种发生反应，能够以良好的产率生成环丙烷。具有两个二级卤素的二卤化物的反应立体选择性地进行，主要产物为反式异构体。

  DOI：

  10.1246/cl.2002.290

文献信息

• Preparation of 1,4-dienes by the reaction of titanocene cycloalkenylidenes with 1-alkenes
  作者：Takeshi Takeda、Yuzo Teramoto、Yuta Inoue、Akira Tsubouchi

  DOI：10.1016/j.tetlet.2015.04.124

  日期：2015.6

  o-1-cycloalkenes with titanocene(II)-triethyl phosphite complex, reacted with styrene derivatives to produce (E)-1,4-dienes. Their reaction with vinyl-borane and -silane also produced 1-boryl- and silyl-1,4-dienes, which were transformed into 1-substituted 1,4-dienes through the palladium(0)-catalyzed or copper(I)-promoted reaction with organic halides.

  通过用钛茂（II）-三乙基亚磷酸酯络合物对3-（芳硫基）-1-氯-1-环烯烃进行还原钛化反应生成的二茂钛环烯基与苯乙烯衍生物反应生成（E）-1,4-二烯。他们与乙烯基硼烷和-硅烷的反应还产生了1-硼基-和甲硅烷基-1,4-二烯，它们通过钯（0）催化或铜（I）-被转化为1-取代的1,4-二烯。促进了与有机卤化物的反应。
• Preparation of silyl polyenol ethers by carbonyl olefination of silyl esters
  作者：Takeshi Takeda、Tatsuya Fukada、Akira Tsubouchi

  DOI：10.1016/j.tetlet.2014.01.040

  日期：2014.2

  Silyl enol ethers were produced by the carbonyl olefination of silyl esters with titanium carbene complexes generated by the desulfurizative titanation of thioacetals. The regioselective preparation of silyl dienol and trienol ethers has been achieved by using unsaturated silyl esters and thioacetals.

  甲硅烷基烯醇醚是通过将甲硅烷基酯的羰基烯化与硫代乙缩醛的脱硫钛化反应生成的钛碳烯配合物而制得的。甲硅烷基二烯醇和三烯醇醚的区域选择性制备已经通过使用不饱和甲硅烷基酯和硫代缩醛实现。
• [2 + 2 + 1] Cycloaddition between Alkynes, Acrylates, and Titanocene(II): Regioselective Formation of 5-Alkoxycarbonyltitanacyclopent-2-enes and Their Addition to Carbonyls
  作者：Shigeki Oishi、Kaoru Ohomika、Akira Tsubouchi、Takeshi Takeda

  DOI：10.1246/cl.2010.723

  日期：2010.7.5

  5-Alkoxycarbonyltitanacyclopent-2-enes were produced regioselectively by the [2 + 2 + 1] cycloaddition between alkynes, acrylates, and titanocene(II) reagent Cp 2 Ti[P(OEt) 3 ] 2 . Although the titanacycles were inactive toward carbonyl compounds, their addition proceeded in the presence of titanocene(II).

  通过炔烃、丙烯酸酯和二茂钛 (II) 试剂 Cp 2 Ti[P(OEt) 3 ] 2 之间的 [2 + 2 + 1] 环加成反应，区域选择性地制备了 5-烷氧基羰基钛环戊-2-烯。尽管钛环对羰基化合物无活性，但它们的加成是在二茂钛 (II) 存在下进行的。
• Synthesis of carbocycles and heterocycles by the titanocene(II)-promoted reactions of thioacetals
  作者：Takeshi Takeda、Md.Abdur Rahim、Mayumi Takamori、Kenjirou Yanai、Tooru Fujiwara

  DOI：10.1016/s0277-5387(99)00388-5

  日期：2000.3

  The preparation of carbocyclic and heterocyclic compounds by the low-valent titanium species-promoted intramolecular reactions of thioacetals was studied. The cyclization of thioacetals having an olefin moiety proceeded with the loss of terminal olefin carbon to produce the corresponding five-, six-, and seven-membered cycloalkenes when they were treated with the low-valent titanium species Cp2Ti[P(OEt)(3)](2). This method has been successfully applied to the syntheses of cyclic unsaturated amines and ethers. When S-[3,3-bis (phenylthio) propyl] thioalkanoates were treated with the low-valent titanium species, the intramolecular carbonyl olefination proceeded to produce 5-substituted 2,3-dihydrothiophenes. (C) 2000 Elsevier Science Ltd All rights reserved.
• New Carbonyl Olefination Using Thioacetals
  作者：Yasuo Horikawa、Mikako Watanabe、Tooru Fujiwara、Takeshi Takeda

  DOI：10.1021/ja962240d

  日期：1997.2.1