2-(hydroxymethyl)-2-(((4-methoxybenzyl)oxy)methyl)propane-1,3-diol | 186090-81-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(hydroxymethyl)-2-(((4-methoxybenzyl)oxy)methyl)propane-1,3-diol
• 英文别名: 2-(Hydroxymethyl)-2-[(4-methoxyphenyl)methoxymethyl]propane-1,3-diol
• CAS: 186090-81-3
• 化学式: C₁₃H₂₀O₅
• 分子量: 256.299
• InChiKey: BRIAGXLQRKPEMP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  18
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  79.2
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-(hydroxymethyl)-2-(((4-methoxybenzyl)oxy)methyl)propane-1,3-diol 在 吡啶 、 sodium hydride 作用下， 以 四氢呋喃 、 mineral oil 为溶剂， 反应 18.0h， 生成 3-[(4-methoxybenzyloxy)methyl]-oxetan-3-ylmethanol
  参考文献：
  名称：

  设计和合成新颖的1,25-二羟基维生素D 3类似物，其螺环氧杂环丁烷稠合在A环的C2位置

  摘要：

  设计并合成了四种结构新颖的1,25-二羟基维生素D 3（3a - d）的立体异构体，它们在A环的C2位置稠合了螺-氧杂环丁烷。维生素D类似物（3a，b）和（3c，d）的必需的A环烯炔前体（13a，b）分别根据十一步程序由季戊四醇合成。使用牛胸腺维生素D受体（VDR）对类似物进行的初步生物学评估表明，掺入螺-氧杂环丁烷部分而不是宝石在C 2位的-二甲基对VDR亲和力具有有益的作用。

  DOI：

  10.1016/j.bmc.2013.06.032
• 作为产物：
  描述：

  5,5-bis(acetyloxymethyl)-2-(p-methoxyphenyl)-1,3-dioxane 在 甲醇 、 三乙基硅烷 、 sodium 、 二氯乙基铝 作用下， 以 二氯甲烷 、 甲苯 为溶剂， 反应 1.58h， 生成 2-(hydroxymethyl)-2-(((4-methoxybenzyl)oxy)methyl)propane-1,3-diol
  参考文献：
  名称：

  Synthesis of a Nonavalent Mannoside Glycodendrimer Based on Pentaerythritol

  摘要：

  A nonavalent glycodendrimer bearing terminal alpha-D-mannopyranoside units has been synthesized with a convergent approach. Terminal trivalent mannoside dendrons bearing p-halophenyl ethers were prepared by glycosylation of pentaerythritol derivatives having three 2-hydroxyethyl ether substituents. Two efficient routes were developed for the synthesis of the pentaerythritol-based core (17), which has three terminal propargyl ethers. Conditions were found under which the triple Sonogashira coupling reaction of the dendron and the tri-O-propargyl ether (17) proceeded efficiently. The product was deprotected and it and precursors were fully characterized by NMR spectroscopy and FT-ICR mass spectrometry.

  DOI：

  10.1021/jo052045u

文献信息

• CATIONIC LIPIDS
  申请人：Takeda Pharmaceutical Company Limited

  公开号：US20200331841A1

  公开（公告）日：2020-10-22

  The present invention provides a technique that enables introduction of active ingredients, in particular, nucleic acids, into cells with superior efficiency; and cationic lipids, etc., for use in the technique. The compound or a salt thereof according to the present invention is a compound represented by formula (I) or a salt thereof. In formula (I), n represents an integer of 2 to 5, R represents a linear C 1-5 alkyl group, a linear C 7-11 alkenyl group, or a linear C 11 alkadienyl group, and wavy lines each independently represent a cis-bond or a trans-bond.

  本发明提供了一种技术，能够以优越的效率将活性成分，特别是核酸，引入细胞中；以及用于该技术的阳离子脂质等。根据本发明的化合物或其盐是由式（I）表示的化合物或其盐。在式（I）中，n代表2到5的整数，R代表线性C1-5烷基基团、线性C7-11烯基基团或线性C11烯二烯基团，波浪线各自独立表示顺式键或反式键。
• Synthesis of New Components for Tethered Bilayer Membranes and Preliminary Surface Characterization.
  作者：Christopher J.Burns、Leslie D. Field、Peter Culshaw、Mohammed Islam、Damon D. Ridley、Jacqueline Morgan、Burkhard Raguse、Lech Wieczorek、Matthew Wilkinson、Valentina Vignevich

  DOI：10.1071/ch99159

  日期：——

  Two analogues of the membrane-forming species PhCH2SS(C24H40O14)(C20H41) (1) have been prepared via short synthetic routes. The compounds readily form self-assembled monolayers on gold. PhCH2SS(C27H45O16)(C20H41)2 PhCH2SS(C29H48O17)(C20H41)3

  已准备好两种模拟膜形成物种PhCH2SS(C24H40O14)(C20H41)(1)，通过简短的合成途径。这些化合物容易在金表面上形成自组装单分子层。PhCH2SS(C27H45O16)(C20H41)2和PhCH2SS(C29H48O17)(C20H41)3。
• Self-Assembly of Maltoheptaose-<i>block</i>-polycaprolactone Copolymers: Carbohydrate-Decorated Nanoparticles with Tunable Morphology and Size in Aqueous Media
  作者：Takuya Isono、Kana Miyachi、Yusuke Satoh、Ryosuke Nakamura、Yao Zhang、Issei Otsuka、Kenji Tajima、Toyoji Kakuchi、Redouane Borsali、Toshifumi Satoh

  DOI：10.1021/acs.macromol.6b00781

  日期：2016.6.14

  This paper describes the systematic investigation into the aqueous self-assembly of a series of block copolymers (BCPs) consisting of maltoheptaose (MH; as the A block) and poly(e-caprolactone) (PCL; as the B block), i.e., linear AB-type diblock copolymers with varied PCL molecular weights (MH-b-PC1-(2.5(k,3.3k,5k10k))), AB(y)-type = 2, MH-b(PCL5k) 2; y = 3, MH-b-(PCL3.3k)(3)), A(2)B(2)-type ((MH)(2)-b(PCL(5)k)(2)), and AxB-type miktoarm star polymers (x = 2, (MH)2-b-PCL10k; x = 3, (MH)(3)-b-PCLiok), which had been precisely synthesized via the combination of the living ring opening polymerization and click reaction. Under similar conditions, the nanoprecipitation method was employed to self -assemble them in an aqueous medium. Imaging and dynamic light scattering techniques indicated the successful formation of the carbohydrate -decorated nanoparticles via self -assembly. The MH-b-PCLs formed regular core shell micellar nanoparticles with the hydrodynamic "radius (Rh) of 17-43 nm. MH-b-(PCL5k)2 and MH-b-(PCL3.3k)(3), which have an NPCL comparable to MH-b-PCLiok, were found to form large compound micelles with relatively large radii (Rh of 49 and 56 nm, respectively). On the other hand, (MH),-b-(PCL5k),, (MH),-b-PCLiok, and (MH)3-bPCLiok predominantly formed the regular core shell micellar nanoparticles (Rh = 29-39 nm) with a size smaller than that of MH-b-PCLiok (Rh = 43 nm).
• Synthesis and application of α-?-mannosyl clusters as photoaffinity ligands for mannose-binding proteins: Concanavalin A as a model receptor
  作者：J Lehmann

  DOI：10.1016/s0008-6215(96)00207-8

  日期：1996.11.20