乙酸-1-14C | 2845-03-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 乙酸-1-14C
• 中文别名: [1-14C]乙酸
• 英文名称: ¹⁴C-acetic acid
• 英文别名: [1-¹⁴C]-acetic acid；[1-14C]acetic acid；acetic[1-14C] acid；[1-14C]-acetate；[14C]acetate；acetic acid；Acetic acid C-14
• CAS: 2845-03-6
• 化学式: C₂H₄O₂
• 分子量: 62.0416
• InChiKey: QTBSBXVTEAMEQO-HQMMCQRPSA-N

物化性质

• 闪点：
  40 °C

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  4
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 危险品标志：
  C
• 安全说明：
  S16,S26,S36/37/39,S45
• 危险类别码：
  R35,R10
• 危险品运输编号：
  UN 2910 7

SDS

Version 1.6
Regulation (EC) No 1907/2006

---

1 - Product and Company Information

---

Product Name ACETIC ACID-UL-14C

---

2 - Hazards Identification

---

SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Flammable. Causes severe burns.

---

3 - Composition/Information on Ingredients

---

Product Name CAS # EC no Annex I
Index Number
ACETIC ACID-1-14C 2845-03-6 None None
Formula C2H4O2
Molecular Weight 60,0500 AMU

---

4 - First Aid Measures

---

AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician immediately. Do not induce vomiting.

---

5 - Fire Fighting Measures

---

SIGMA www.molbase.com
EXTINGUISHING MEDIA
Suitable: For small (incipient) fires, use media such as
"alcohol" foam, dry chemical, or carbon dioxide. For large
fires, apply water from as far as possible. Use very large
quantities (flooding) of water applied as a mist or spray; solid
streams of water may be ineffective. Cool all affected
containers with flooding quantities of water.
SPECIAL RISKS
Specific Hazard(s): Flammable liquid. Emits toxic fumes under
fire conditions.
Explosion Hazards: Vapor may travel considerable distance to
source of ignition and flash back. Container explosion may occur
under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.

---

6 - Accidental Release Measures

---

PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area. Handle as a radioactive spill.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Cover with dry-lime, sand, or soda ash. Place in covered
containers using non-sparking tools and transport outdoors.
Ventilate area and wash spill site after material pickup is
complete.

---

7 - Handling and Storage

---

HANDLING
Directions for Safe Handling: Do not breathe vapor. Do not get
in eyes, on skin, on clothing. Avoid prolonged or repeated
exposure.
STORAGE
Conditions of Storage: Keep tightly closed. Keep away from heat,
sparks, and open flame.
Store at 2-8°C

---

8 - Exposure Controls / Personal Protection

---

ENGINEERING CONTROLS
Safety shower and eye bath. Use nonsparking tools. Use only in a
chemical fume hood.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Discard contaminated
shoes. Wash thoroughly after handling.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Use respirators and components tested and
approved under appropriate government standards such as NIOSH (US)
or CEN (EU). Where risk assessment shows air-purifying respirators
SIGMA www.molbase.com
are appropriate use a full-face respirator with multi-purpose
combination (US) or type ABEK (EN 14387) respirator cartridges as
a backup to engineering controls. If the respirator is the sole
means of protection, use a full-face supplied air respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
Special Protective Measures: Faceshield (8-inch minimum).

---

9 - Physical and Chemical Properties

---

Appearance Physical State: Liquid
Property Value At Temperature or Pressure
pH N/A
BP/BP Range N/A
MP/MP Range N/A
Flash Point 40,000 °C Method: closed cup
Flammability N/A
Autoignition Temp 427,00 °C
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits Lower: 4,000 %
Upper: 16,000 %
Vapor Pressure 11,400000000 mmHg 20,00 °C
Partition Coefficient N/A
Viscosity N/A
Vapor Density 2,070 g/l
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A

---

10 - Stability and Reactivity

---

STABILITY
Stable: Stable.
Conditions to Avoid: Moisture.
Materials to Avoid: Acids, Bases, Oxidizing agents, Soluble
carbonates and phosphates, Hydroxides, Oxides, Metals, Acid
anhydrides, Peroxides, Permanganates, Amines, Alcohols.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur

---

11 - Toxicological Information

---

SIGNS AND SYMPTOMS OF EXPOSURE
Ingestion or inhalation of concentrated acetic acid causes
damage to tissues of the respiratory and digestive tracts.
Symptoms include: hematemesis, bloody diarrhea, edema and/or
SIGMA www.molbase.com
perforation of the esophagus and pylorus, hematuria, anuria,
uremia, albuminuria, hemolysis, convulsions, bronchitis,
pulmonary edema, pneumonia, cardiovascular collapse, shock, and
death. Direct contact or exposure to high concentrations of
vapor with skin or eyes can cause: erythema, blisters, tissue
destruction with slow healing, skin blackening, hyperkeratosis,
fissures, corneal erosion, opacification, iritis,
conjunctivitis, and possible blindness. To the best of our
knowledge, the chemical, physical, and toxicological properties
have not been thoroughly investigated. Symptoms of exposure may
include burning sensation, coughing, wheezing, laryngitis,
shortness of breath, headache, nausea, and vomiting. Inhalation
may result in spasm, inflammation and edema of the larynxand
bronchi, chemical pneumonitis, and pulmonary edema. Material is
extremely destructive to tissue of the mucous membranes and
upper respiratory tract, eyes, and skin.
ROUTE OF EXPOSURE
Skin Contact: Causes burns.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: Causes burns.
Inhalation: May be harmful if inhaled. Material is extremely
destructive to the tissue of the mucous membranes and upper
respiratory tract.
Ingestion: May be harmful if swallowed.
TARGET ORGAN INFORMATION
Teeth. Kidneys.
CONDITIONS AGGRAVATED BY EXPOSURE
Severe, acute pancreatitis may occur after ingestion of
concentrated acetic acid.
CHRONIC EXPOSURE - CARCINOGEN
Result: Contains a radioactive isotope which may produce cancer
and genetic mutation.

---

12 - Ecological Information

---

No data available.

---

13 - Disposal Considerations

---

SUBSTANCE DISPOSAL
Dispose of spilled material as radioactive waste. Consult local,
state, and federal regulations on the disposal of radioactive
waste. Observe all federal, state, and local environmental
regulations.

---

14 - Transport Information

---

RID/ADR
UN#: 2910
Class: 7
Proper Shipping Name: Radioactive material, excepted
package, limited quantity of material
IMDG
UN#: 2910
Class: 7
SIGMA www.molbase.com
Proper Shipping Name: RADIOACTIVE MATERIAL, EXCEPTED
PACKAGE - LIMITED QUANTITY OF MATERIAL
Marine Pollutant: No
Severe Marine Pollutant: No
IATA
UN#: 2910
Class: 7
Proper Shipping Name: Radioactive material, excepted
package, limited quantity of material
Inhalation Packing Group I: No

---

15 - Regulatory Information

---

CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
INDICATION OF DANGER: R-C
Radioactive. Corrosive.
R-PHRASES: 10-35
Flammable. Causes severe burns.
S-PHRASES: 16-26-36/37/39-45
Keep away from sources of ignition - no smoking. In case of
contact with eyes, rinse immediately with plenty of water and
seek medical advice. Wear suitable protective clothing, gloves,
and eye/face protection. In case of accident or if you feel
unwell, seek medical advice immediately (show the label where
possible).
Caution: Substance not yet fully tested (EU).
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 3
Self-Classification

---

16 - Other Information

---

WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2010 Co. License granted to make
unlimitedpaper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
SIGMA www.molbase.com

---

SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  乙酸-1-14C 在 磷化氢 、 溴 、 乙酸酐 作用下， 反应 2.0h， 生成 [1-¹⁴C]bromoacetic acid
  参考文献：
  名称：

  不同位置放射性碳标记的德兰环烷的合成

  摘要：

  [U- 14 C]溴苯，根据文献方法由[ 14 C]碳酸钡制备，转化（Li/二乙醚）为[ 14 C]苯基锂，后者与樟脑缩合生成[U- 14 C-苯基]冰片：2。后者在转化为其钠盐后，与二甲氨基乙基氯反应，得到[ 14 C-Ar]德环环烷，将其作为富马酸盐分离。这种由[ 14 C]BaCO 3 的8步合成得到12%的总产率。[1- 14 C]乙酸钠，通过标准的 5 步文献程序，被转化为 N,N-二甲氨基乙基-1- 14 C 氯化物 5，后者与 2-苯基冰片的钠衍生物缩合生成 [1- 14 C-侧链]Deramciclane，再次分离为富马酸盐。这种由[ 14 C]BaCO 3 的6步合成得到8％的总产率。两种合成的比放射性分别为40 mCi/mmol和21 mCi/mmol；化学和放射化学纯度均优于 98%。

  DOI：

  10.1002/(sici)1099-1344(199712)39:12<1011::aid-jlcr49>3.0.co;2-z
• 作为产物：
  描述：

  乙酸钠-1-14C 在 硫酸 作用下， 以 not given 为溶剂， 生成 乙酸-1-14C
  参考文献：
  名称：

  Muxart, R.; Daudel, P.; Rigolet, C., Bulletin de la Societe Chimique de France

  摘要：

  DOI：

文献信息

• 7-Oxo-24ξ(28)-dihydrocycloeucalenol, a potent inhibitor of plant sterol biosynthesis
  作者：Alain Rahier、Paulette Schmitt、Pierre Benveniste

  DOI：10.1016/0031-9422(82)83024-0

  日期：1982.1

  from higher plant cells catalyses the opening of the cyclopropane ring of cycloeucalenol yielding obtusifoliol. 7-Oxo-24ξ(28)-dihydrocycloeucalenol was not a substrate but behaved like a potent inhibitor of the isomerase. The inhibition was reversible and highly specific; the inhibitor needed the presence of the 7-oxo group, the cyclopropane ring and the absence of a 4β-methyl group to be active. Other

  摘要 来自高等植物细胞的环桉油醇-钝叶醇异构酶催化环桉油醇的环丙烷环打开，产生钝叶醇。7-Oxo-24ξ(28)-dihydrocycloeucalenol 不是底物，但表现得像异构酶的有效抑制剂。这种抑制作用是可逆的且具有高度特异性；抑制剂需要存在 7-氧代基团、环丙烷环和不存在 4β-甲基基团才能起作用。7-oxo-24ξ(28)-dihydrocycloeucalenol 不会抑制其他参与植物甾醇生物合成的酶，如 2, 3-oxidosqualene-cycloartenol cyclase 和 S-adenosyl methionine cycloartenol C-24 甲基转移酶。
• Biosynthesis of a retrochalcone, echinatin: a feeding study with advanced precursors
  作者：Shin-lchi Ayabe、Tsutomu Furuya

  DOI：10.1016/s0040-4039(01)93286-1

  日期：1981.1

  Feeding experiments with 14C-labeled compounds established that a dibenzoylmethane, licodione(), is an obligate intermediate in the biosynthesis of a retrochalcone, echinatin(1).

  用14种C标记的化合物进料的实验确定，二苯甲酰甲烷licodione（）是逆向查尔松（紫锥花）（1 ）的生物合成中的专性中间体。
• Anker, Journal of Biological Chemistry, 1948, vol. 176, p. 1334
  作者：Anker

  DOI：——

  日期：——
• Synthesis and Spectroscopic Characterization of [1′-14C]Ubiquinone-2, [1′-14C]-5-Demethoxy-5-hydroxyubiquinone-2, and [1′-14C]-5-Demethoxyubiquinone-2
  作者：Anita van der Klei、Robertus L. P. de Jong、Johan Lugtenburg、Aloysius G. M. Tielens

  DOI：10.1002/1099-0690(200209)2002:17<3015::aid-ejoc3015>3.0.co;2-g

  日期：2002.9
• Tracer Studies with Radioactive Carbon. The Exchange between Acetic Anhydride and Sodium Acetate
  作者：S. Ruben、M. B. Allen、P. Nahinsky

  DOI：10.1021/ja01264a513

  日期：1942.12