1-(5-溴-2-吡啶基)吡咯烷-2,5-二酮 | 213193-28-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 1-(5-溴-2-吡啶基)吡咯烷-2,5-二酮
• 英文名称: 1-(5-bromo-2-pyridyl)pyrrolidine-2,5-dione
• 英文别名: 1-(5-Bromopyridin-2-yl)pyrrolidine-2,5-dione
• CAS: 213193-28-3
• 化学式: C₉H₇BrN₂O₂
• 分子量: 255.071
• InChiKey: LAKLVAMMQQVVQG-UHFFFAOYSA-N

物化性质

• 沸点：
  488.6±30.0 °C(Predicted)
• 密度：
  1.742±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  50.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-(5-溴-2-吡啶基)吡咯烷-2,5-二酮 在 sodium tetrahydroborate 作用下， 以 四氢呋喃 、 水 为溶剂， 以68%的产率得到1-(5-溴-2-吡啶基)-2-吡咯烷酮
  参考文献：
  名称：

  2-Amino-5-aryl-pyridines as selective CB2 agonists: Synthesis and investigation of structure–activity relationships

  摘要：

  2-Amino-5-aryl-pyridines, exemplified by compound 1, had been identified as a synthetically tractable series of CB2 agonists from a high-throughput screen of the GlaxoSmithKline compound collection. Described herein are the results of an investigation of the structure-activity relationships (SAR) which led to the identification a number of potent and selective agonists. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.10.041
• 作为产物：
  描述：

  丁二酸酐 、 2-氨基-5-溴吡啶 在 乙酰氯 作用下， 以 5,5-dimethyl-1,3-cyclohexadiene 为溶剂， 反应 8.0h， 以80%的产率得到1-(5-溴-2-吡啶基)吡咯烷-2,5-二酮
  参考文献：
  名称：

  [EN] PLANT GROWTH REGULATING COMPOUNDS
  [FR] COMPOSÉS RÉGULATEURS DE CROISSANCE DES PLANTES

  摘要：

  本发明涉及新型非甾体类固醇植物激素类似物衍生物，涉及用于制备它们的工艺和中间体，涉及包含它们的植物生长调节剂组合物，以及使用它们控制植物生长和/或促进种子萌发的方法。

  公开号：

  WO2013164245A1

文献信息

• Wright; Hageman; McClure, Journal of Heterocyclic Chemistry, 1998, vol. 35, # 3, p. 717 - 723
  作者：Wright、Hageman、McClure

  DOI：——

  日期：——
• [EN] PLANT GROWTH REGULATING COMPOUNDS<br/>[FR] COMPOSÉS RÉGULANT LA CROISSANCE DES PLANTES
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：WO2014131732A2

  公开（公告）日：2014-09-04

  The present invention relates to novel non-steroidal brassinosteroid mimetic derivatives, to processes and intermediates for preparing them, to plant growth regulator compositions comprising them and to methods of using them for controlling the growth of plants and/or promoting the germination of seeds.
• [EN] PLANT GROWTH REGULATING COMPOUNDS<br/>[FR] COMPOSÉS RÉGULATEURS DE CROISSANCE DES PLANTES
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：WO2013164245A1

  公开（公告）日：2013-11-07

  The present invention relates to novel non-steroidal brassinosteroid mimetic derivatives, to processes and intermediates for preparing them, to plant growth regulator compositions comprising them and to methods of using them for controlling the growth of plants and/or promoting the germination of seeds.

  本发明涉及新型非甾体类固醇植物激素类似物衍生物，涉及用于制备它们的工艺和中间体，涉及包含它们的植物生长调节剂组合物，以及使用它们控制植物生长和/或促进种子萌发的方法。
• 2-Amino-5-aryl-pyridines as selective CB2 agonists: Synthesis and investigation of structure–activity relationships
  作者：Robert J. Gleave、Paul J. Beswick、Andrew J. Brown、Gerard M.P. Giblin、Carl P. Haslam、David Livermore、Andrew Moses、Neville H. Nicholson、Lee W. Page、Brian Slingsby、Martin E. Swarbrick

  DOI：10.1016/j.bmcl.2009.10.041

  日期：2009.12

  2-Amino-5-aryl-pyridines, exemplified by compound 1, had been identified as a synthetically tractable series of CB2 agonists from a high-throughput screen of the GlaxoSmithKline compound collection. Described herein are the results of an investigation of the structure-activity relationships (SAR) which led to the identification a number of potent and selective agonists. (C) 2009 Elsevier Ltd. All rights reserved.