1-(5-溴-2-吡啶基)-2-吡咯烷酮 | 928775-04-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 1-(5-溴-2-吡啶基)-2-吡咯烷酮
• 中文别名: 1-(5-溴吡啶-2-基)吡咯烷-2-上
• 英文名称: 1-(5-bromopyridin-2-yl)pyrrolidin-2-one
• CAS: 928775-04-6
• 化学式: C₉H₉BrN₂O
• 分子量: 241.087
• InChiKey: BZJQQRCFYKSQKX-UHFFFAOYSA-N

物化性质

• 沸点：
  442.7±30.0 °C(Predicted)
• 密度：
  1.608±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  33.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-(5-溴-2-吡啶基)-2-吡咯烷酮 在 lithium hexamethyldisilazane 、 N-氟代双苯磺酰胺 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 以100%的产率得到1-(5-bromopyridin-2-yl)-3-fluoropyrrolidin-2-one
  参考文献：
  名称：

  [EN] NOVEL COMPOUNDS, PHARMACEUTICAL COMPOSITION AND METHODS FOR USE IN TREATING METABOLIC DISORDERS
  [FR] NOUVEAUX COMPOSÉS, LEURS COMPOSITIONS PHARMACEUTIQUES ET MÉTHODES D'UTILISATION DANS LE TRAITEMENT DE TROUBLES MÉTABOLIQUES

  摘要：

  本发明涉及公式（I）的新化合物及其在治疗代谢性疾病中的应用。

  公开号：

  WO2011151434A1
• 作为产物：
  描述：

  1-(5-溴-2-吡啶基)吡咯烷-2,5-二酮 在 sodium tetrahydroborate 作用下， 以 四氢呋喃 、 水 为溶剂， 以68%的产率得到1-(5-溴-2-吡啶基)-2-吡咯烷酮
  参考文献：
  名称：

  2-Amino-5-aryl-pyridines as selective CB2 agonists: Synthesis and investigation of structure–activity relationships

  摘要：

  2-Amino-5-aryl-pyridines, exemplified by compound 1, had been identified as a synthetically tractable series of CB2 agonists from a high-throughput screen of the GlaxoSmithKline compound collection. Described herein are the results of an investigation of the structure-activity relationships (SAR) which led to the identification a number of potent and selective agonists. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.10.041

文献信息

• Pyridine Derivative and Medicinal Agent
  申请人：Fujihara Hidetaka

  公开号：US20130225548A1

  公开（公告）日：2013-08-29

  A main object of the present invention is to provide a novel pyridine derivative represented by the following general formula [1] or a pharmaceutically acceptable salt thereof. In formula [1], R represents an aryl group or a heteroaryl group, which may be substituted by an optionally substituted alkyl group, a hydroxy group, a halogen atom or a group represented by general formula [2]. In formula [2], -L 1 -L 2 -L 3 -R A [2] L 1 and L 3 independently represent a single bond, an alkylene group or a cycloalkylene group; L 2 represents a single bond, O, or NR B ; R B represents H or an optionally substituted alkyl group; and R A represents B, an amino group, a cyano group, a hydroxy group, an alkoxy group, an aryl group, a monoalkylamino group, a dialkylamino group, a carbamoyl group, an alkyloxycarbonyl group, a monoalkylaminocarbonyl group, a dialkylaminocarbonyl group, an alkylcarbonylamino group, and a saturated heterocyclic group, among other groups.

  本发明的一个主要对象是提供一种由下述通用式[1]表示的新型吡啶衍生物或其药学上可接受的盐。在式[1]中，R代表芳基或杂芳基，可以被可选择地取代的烷基、羟基、卤原子或通式[2]所代表的基团所取代。在式[2]中，-L1-L2-L3-RA[2]L1和L3独立地代表单键、烷基或环烷基；L2代表单键、O或NRB；RB代表氢或可选择地取代的烷基；RA代表B、氨基、氰基、羟基、烷氧基、芳基、单烷基氨基、双烷基氨基、氨基甲酰基、烷氧羰基、单烷基氨基羰基、双烷基氨基羰基、烷基羰基氨基和饱和杂环基等基团，以及其他基团。
• ANTIMICROBIAL INDOLINE COMPOUNDS FOR TREATMENT OF BACTERIAL INFECTIONS
  申请人：Gordeev Mikhail Fedorovich

  公开号：US20100069441A1

  公开（公告）日：2010-03-18

  The present invention provides indoline heterocyclic compounds of the following formula I: or pharmaceutically acceptable salts, prodrugs, solvates, or hydrates thereof useful as antibacterial agents, pharmaceutical compositions containing them, methods for their use, and methods for preparing these compounds.

  本发明提供了以下式I的吲哚杂环化合物或其药学上可接受的盐、前药、溶剂合物或水合物，可用作抗菌剂，包含它们的药物组合物，以及使用它们的方法和制备这些化合物的方法。
• Antimicrobial Cyclocarbonyl Heterocyclic Compounds For Treatment Of Bacterial Infections
  申请人：Gordeev Mikhail Fedorovich

  公开号：US20120065170A1

  公开（公告）日：2012-03-15

  The present invention provides indoline compounds of the following formula I: or pharmaceutically acceptable salts, prodrugs, solvates, or hydrates thereof useful as antibacterial agents, pharmaceutical compositions containing them, methods for their use, and methods for preparing these compounds.

  本发明提供了以下式I的吲哚啉化合物：或其药用可接受的盐、前药、溶剂合物或水合物，作为抗菌剂使用，包含它们的药物组合物，其使用方法，以及制备这些化合物的方法。
• Pyrazolo [3,4-D]Azepine Derivatives as Histamine H3 Antagonists
  申请人：Bamford Mark James

  公开号：US20080176832A1

  公开（公告）日：2008-07-24

  The present invention relates to novel pyrazole derivatives of formula I having pharmacological activity as H3 antagonists processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.

  本发明涉及一种新的式I的吡唑衍生物，具有作为H3拮抗剂的药理活性，其制备方法，包含它们的组合物以及它们在治疗神经和精神障碍中的应用。
• COMPOUNDS, PHARMACEUTICAL COMPOSITION AND METHODS FOR USE IN TREATING METABOLIC DISORDERS
  申请人：Hoveyda Hamid

  公开号：US20110230477A1

  公开（公告）日：2011-09-22

  The present invention is directed to novel compounds of formula (I) and their use in treating metabolic diseases.

  本发明涉及式（I）的新化合物及其在治疗代谢性疾病方面的应用。