ethyl-methyl-maleic acid dimethyl ester | 41654-26-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: ethyl-methyl-maleic acid dimethyl ester
• 英文别名: Aethyl-methyl-maleinsaeure-dimethylester；2-ethyl-3-methylmaleic acid dimethyl ester；Dimethyl-2-ethyl-3-methylmaleat；Dimethyl 2-ethyl-3-methylmaleate；dimethyl (Z)-2-ethyl-3-methylbut-2-enedioate
• CAS: 41654-26-6
• 化学式: C₉H₁₄O₄
• 分子量: 186.208
• InChiKey: ALSBSLYSTXSJQN-SREVYHEPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  ethyl-methyl-maleic acid dimethyl ester 在 sodium hydroxide 、 水 作用下， 以 1,4-二氧六环 为溶剂， 反应 4.0h， 以100%的产率得到2-ethyl-3-methylmaleic acid disodium salt
  参考文献：
  名称：

  Metallo-beta-lactamase inhibitors

  摘要：

  一种新的金属β-内酰胺酶抑制剂，作为一种药物用于抑制β-内酰胺类抗生素的失活并恢复抗菌活性。具有一般式（I）的马来酸衍生物具有金属β-内酰胺酶抑制活性。通过将一般式（I）的化合物与β-内酰胺类抗生素结合，可以恢复β-内酰胺酶产生细菌对β-内酰胺类抗生素的抗菌活性。

  公开号：

  US20080090825A1
• 作为产物：
  描述：

  dimethyl 2-ethyl-3-methylbicyclo[2.2.1]hept-5-ene-2,3-dicarboxylate 以91%的产率得到
  参考文献：
  名称：

  GIRARD, C.;BLOCH, R., TETRAHEDRON LETT., 1982, 23, N 36, 3683-3686

  摘要：

  DOI：

文献信息

• METALLO-BETA-LACTAMASE INHIBITORS
  申请人：Chikauchi Ken

  公开号：US20120071457A1

  公开（公告）日：2012-03-22

  A new metallo-β-lactamase inhibitor which acts as a medicament for inhibiting the inactivation of β-lactam antibiotics and recovering anti-bacterial activities is disclosed. The maleic acid derivatives having the general formula (I) have metallo-β-lactamase inhibiting activities. It is possible to recover the anti-bacterial activities of β-lactam antibiotics against metallo-β-lactamase producing bacteria by combining the compound of the general formula (I) with β-lactam antibiotics.

  本发明揭示了一种新型金属β-内酰胺酶抑制剂，可作为药物用于抑制β-内酰胺类抗生素的失活并恢复其抗菌活性。具有通式（I）的马来酸衍生物具有金属β-内酰胺酶抑制活性。将通式（I）化合物与β-内酰胺类抗生素结合，可以恢复β-内酰胺酶产生的细菌对β-内酰胺类抗生素的抗菌活性。
• Metallo-β-lactamase inhibitors
  申请人：Meiji Seika Kaisha, Ltd.

  公开号：US08093294B2

  公开（公告）日：2012-01-10

  A new metallo-β-lactamase inhibitor which acts as a medicament for inhibiting the inactivation of β-lactam antibiotics and recovering anti-bacterial activities is disclosed. The maleic acid derivatives having the general formula (I) have metallo-β-lactamase inhibiting activities. It is possible to recover the anti-bacterial activities of β-lactam antibiotics against metallo-β-lactamase producing bacteria by combining the compound of the general formula (I) with β-lactam antibiotics.

  本发明公开了一种新型金属β-内酰胺酶抑制剂，可用作药物，用于抑制β-内酰胺类抗生素的失活并恢复其抗菌活性。具有通式（I）的马来酸衍生物具有金属β-内酰胺酶抑制活性。通过将通式（I）化合物与β-内酰胺类抗生素结合，可以恢复β-内酰胺酶产生菌株对β-内酰胺类抗生素的抗菌活性。
• METALLO-B-LACTAMASE INHIBITORS
  申请人：MEIJI SEIKA KAISHA, LTD.

  公开号：US20160151322A1

  公开（公告）日：2016-06-02

  A new metallo-β-lactamase inhibitor which acts as a medicament for inhibiting the inactivation of β-lactam antibiotics and recovering anti-bacterial activities is disclosed. The maleic acid derivatives having the general formula (I) have metallo-β-lactamase inhibiting activities. It is possible to recover the anti-bacterial activities of β-lactam antibiotics against metallo-β-lactamase producing bacteria by combining the compound of the general formula (I) with β-lactam antibiotics.

  揭示了一种新的金属β-内酰胺酶抑制剂，可作为药物用于抑制β-内酰胺类抗生素的失活并恢复其抗菌活性。具有通式(I)的马来酸衍生物具有金属β-内酰胺酶抑制活性。通过将通式(I)的化合物与β-内酰胺类抗生素结合，可以恢复β-内酰胺酶产生的细菌对β-内酰胺类抗生素的抗菌活性。
• METALLO-BETA-LACTAMASE INHIBITOR
  申请人：Meiji Seika Kaisha, Ltd.

  公开号：EP1941873A1

  公开（公告）日：2008-07-09

  A new metallo-β-lactamase inhibitor which acts as a medicament for inhibiting the inactivation of β-lactam antibiotics and recovering anti-bacterial activities is disclosed. The maleic acid derivatives having the general formula (I) have metallo-β-lactamase inhibiting activities. It is possible to recover the anti-bacterial activities of β-lactam antibiotics against metallo-β-lactamase producing bacteria by combining the compound of the general formula (I) with β-lactam antibiotics.

  本发明公开了一种新的金属-β-内酰胺酶抑制剂，它可作为一种抑制β-内酰胺类抗生素失活并恢复抗菌活性的药物。具有通式（I）的马来酸衍生物具有金属-β-内酰胺酶抑制活性。通过将通式（I）的化合物与β-内酰胺类抗生素结合，可以恢复β-内酰胺类抗生素对产生金属-β-内酰胺酶的细菌的抗菌活性。
• Stereoselective alkylation of the lithium di-enolate of bis-2,3-carbomethoxy bicyclo[2.2.1]hept-5-ene. A convenient synthesis of mono- and disubstituted fumarate esters.
  作者：C Girard、R Bloch

  DOI：10.1016/s0040-4039(00)88657-8

  日期：1982.1