1-bromodec-3-yne | 66249-75-0

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机溴化物
• 英文名称: 1-bromodec-3-yne
• 英文别名: 1-bromo-3-decyne；3-Decynylbromid；1-Bromo-dec-3-yne
• CAS: 66249-75-0
• 化学式: C₁₀H₁₇Br
• 分子量: 217.149
• InChiKey: NEIGDEGSUJZDMH-UHFFFAOYSA-N

物化性质

• 沸点：
  239.0±23.0 °C(Predicted)
• 密度：
  1.142±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  1-bromodec-3-yne 在 六甲基磷酰三胺 、 lithium aluminium tetrahydride 、 正丁基锂 、 二异丙胺 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 2.5h， 生成
  参考文献：
  名称：

  SmI2 / TEU介导的不饱和卤化物环化。

  摘要：

  SMI的组合2和triethylurea的共轭碱（TEU - ）已被证明有利于不饱和卤化物超过直接还原到更大的程度比其他SMI环化2系还原剂。在SmI 2 / TEU –的存在下，芳基，杂芳基和卤代烷（X = Br，Cl，F）容易发生杂环化和碳环化。

  DOI：

  10.1021/acs.orglett.0c02074
• 作为产物：
  描述：

  dec-3-yn-1-yl methanesulfonate 在 lithium bromide 作用下， 以 丙酮 为溶剂， 生成 1-bromodec-3-yne
  参考文献：
  名称：

  Preparation of halo enol phostones by reaction of acetylenic phosphonate monoesters with (bis-collidine)halo hexafluorophosphate

  摘要：

  Reaction of non-conjugated acetylenic phosphonate monoesters with (bis-collidine) bromo and iodo hexafluorophosphates was found to lead to the formation of halo enol phostones. Depending on the size of the heterocyclic compounds formed (6-8-membered compounds), endo or a mixture of endo and exo cyclization products were obtained. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.06.037

文献信息

• Chain-modified pyridino-N substituted nicotine compounds for use in the treatment of CNS pathologies
  申请人：——

  公开号：US20030225142A1

  公开（公告）日：2003-12-04

  Compounds for treating abuse of nicotinic receptor agonists, addiction to psychostimulant drugs, addiction to opiates, addiction to alcohol, addiction to tobacco products, addiction to nicotine, schizophrenia and related diseases, depression and related conditions, Alzheimer's disease, Parkinson's disease, irritable bowel syndrome, and colitis. The compounds competitively inhibit central nervous system acting nicotinic receptor agonists and act at the putative &agr;3&bgr;2* and &agr;4&bgr;2 neuronal nicotinic receptors in the central nervous system.

  用于治疗尼古丁受体激动剂滥用、对精神刺激药物上瘾、对阿片类药物上瘾、对酒精上瘾、对烟草制品上瘾、对尼古丁上瘾、精神分裂症及相关疾病、抑郁症及相关症状、阿尔茨海默病、帕金森病、肠易激综合征和结肠炎的化合物。这些化合物竞争性地抑制中枢神经系统作用的尼古丁受体激动剂，并在中枢神经系统中的假定的α3β2*和α4β2神经元尼古丁受体起作用。
• 1,3-FATTY DIOL COMPOUNDS AND DERIVATIVES THEREOF
  申请人：REG Life Sciences LLC

  公开号：US20180072645A1

  公开（公告）日：2018-03-15

  The disclosure relates to the field of specialty chemicals. In particular, the disclosure provides novel 1,3-fatty-diol compounds and derivatives thereof which are useful e.g., in the production of personal care products, surfactants, detergents, polymers, paints, coatings, and as emulsifiers, emollients, and thickeners in cosmetics and foods, as industrial solvents and plasticizers, etc.

  本公开涉及专业化学领域。具体而言，本公开提供了新颖的1,3-脂肪二醇化合物及其衍生物，可用于个人护理产品、表面活性剂、洗涤剂、聚合物、涂料、涂层的生产，以及作为化妆品和食品中的乳化剂、润肤剂和增稠剂，工业溶剂和增塑剂等。
• 1,3-FATTY DIOL COMPOUNDS AND GLYCOSYLATED DERIVATIVES THEREOF
  申请人：Genomatica, Inc.

  公开号：EP3795576A1

  公开（公告）日：2021-03-24

  The disclosure relates to the field of specialty chemicals. In particular, the disclosure provides novel 1,3-fatty-diol compounds and alkylpolyglycosides of formula (V), in which R1 and R2 are independently selected from the group consisting of H, a monosaccharide, a disaccharide, a trisaccharide and a polysaccharide, which are bound at an anomeric carbon. These compounds are are useful e.g. in the production of personal care products, surfactants, detergents, polymers, paints, coatings, and as emulsifiers, emollients, and thickeners in cosmetics and foods, as industrial solvents and plasticizers.

  本公开涉及特种化学品领域。特别是，本公开提供了新颖的 1,3-脂肪二醇化合物和式 (V) 烷基聚糖苷，其中 R1 和 R2 独立地选自由 H、单糖、二糖、三糖和多糖组成的组，它们在同分异构碳上结合。这些化合物可用于生产个人护理产品、表面活性剂、洗涤剂、聚合物、油漆、涂料，也可用作化妆品和食品中的乳化剂、润肤剂和增稠剂，还可用作工业溶剂和增塑剂。
• 1,3-fatty diol compounds and derivatives thereof
  申请人：REG Life Sciences LLC

  公开号：US10570074B2

  公开（公告）日：2020-02-25

  The disclosure relates to the field of specialty chemicals. In particular, the disclosure provides novel 1,3-fatty-diol compounds and derivatives thereof which are useful e.g., in the production of personal care products, surfactants, detergents, polymers, paints, coatings, and as emulsifiers, emollients, and thickeners in cosmetics and foods, as industrial solvents and plasticizers, etc.

  本公开涉及特种化学品领域。特别是，本公开提供了新型 1,3-脂肪二醇化合物及其衍生物，可用于生产个人护理产品、表面活性剂、洗涤剂、聚合物、油漆、涂料，也可用作化妆品和食品中的乳化剂、润肤剂和增稠剂，还可用作工业溶剂和增塑剂等。
• Synthesis and Stereochemistry-Activity Relationship of <i>small</i> Bacteriocin, an Autoinducer of the Symbiotic Nitrogen-Fixing Bacterium <i>Rhizobium leguminosarum</i>
  作者：Arata Yajima、Anton A. N. van Brussel、Jan Schripsema、Tomoo Nukada、Goro Yabuta

  DOI：10.1021/ol8005198

  日期：2008.5.1

  The four stereoisomers of small bacteriocin, an autoinducer of the symbiotic nitrogen-fixing bacterium Rhizobium leguminosarum, were synthesized via a versatile methodology for 3'-hydroxyacyl homoserine lactones based on the Nagao asymmetric aldol reaction. The synthetic isomers were much less effective at inhibiting the growth of R. leguminosarum RBL5523 than the natural isomer, showing the importance of stereochemistry for activity.