2-氰基-5-苯基-2,4-戊二烯酸 | 24139-57-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-氰基-5-苯基-2,4-戊二烯酸
• 英文名称: (2E,4E)-2-cyano-5-phenylpenta-2,4-dienoic acid
• 英文别名: 2-cyano-5-phenyl-2,4-pentadienoic acid
• CAS: 24139-57-9
• 化学式: C₁₂H₉NO₂
• 分子量: 199.209
• InChiKey: UBDXZYYYWGIRGN-VCABWLAWSA-N

物化性质

• 熔点：
  208-214°C

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  61.1
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2926909090

反应信息

• 作为反应物：
  描述：

  N,N,N',N'-四(2,3-环氧丙基)环己烷-1,3-二甲胺 、 2-氰基-5-苯基-2,4-戊二烯酸 生成 [3-[[3-[[bis[3-[(2E,4E)-2-cyano-5-phenylpenta-2,4-dienoyl]oxy-2-hydroxypropyl]amino]methyl]cyclohexyl]methyl-[3-[(2E,4E)-2-cyano-5-phenylpenta-2,4-dienoyl]oxy-2-hydroxypropyl]amino]-2-hydroxypropyl] (2E,4E)-2-cyano-5-phenylpenta-2,4-dienoate
  参考文献：
  名称：

  摘要：

  DOI：
• 作为产物：
  描述：

  反式肉桂醛 、 氰乙酸 在 盐酸 作用下， 以 aqueous potassium hydroxide 为溶剂， 以90%的产率得到2-氰基-5-苯基-2,4-戊二烯酸
  参考文献：
  名称：

  Ultraviolet radiation absorbing compositions

  摘要：

  防晒剂组合物是描述含有某些5-苯基戊二烯酸酯，当它们以0.1-50%的重量比包含在载体中时，可作为紫外线过滤剂。

  公开号：

  US04950467A1

文献信息

• [EN] 3-PHENYL-N- ((1, 3, 4) THIADIAZOL-2-YL) -ACRYLAMIDE DERIVATIVES AND RELATED COMPOUNDS AS MODULATORS OF ESTROGEN-RELATED RECEPTORS FOR THE TREATMENT OF E.G. CANCER, RHEUMATOID ARTHRITIS OR NEUROLOGICAL DISORDERS<br/>[FR] DERIVES DE 3-PHENYL-N- ((1, 3, 4) THIADIAZOL-2-YL) -ACRYLAMIDE ET COMPOSES APPARENTES UTILES COMME MODULATEURS DES RECEPTEURS LIES A L'OESTROGENE DANS LE TRAITEMENT DU CANCER, DE L'ARTHRITE RHUMATOIDE OU DE TROUBLES NEUROLOGIQUES
  申请人：X CEPTOR THERAPEUTICS INC

  公开号：WO2005072731A1

  公开（公告）日：2005-08-11

  Compounds of formula (I) are provided as well as compositions and methods of using compounds of formula (I) for modulating the activity of the estrogen-related receptors and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder related to the activity of the estrogen-related receptor. Considering the wide range of activity of the nuclear hormone receptor ERRα, the compounds described herein which are capable of modulating ERRα activity, are useful for treating a range of disease states including cancer, diabetes, obesity, hyperlipidermia, arthritis, atherosclerosis, osteoporosis, anxiety, depression, Parkinson’s disease and Alzheimer’s disease. Formula (I). The substituents are defined in the claims.

  提供了化学式（I）的化合物，以及使用化学式（I）的化合物调节雌激素相关受体活性的组合物和方法，用于治疗、预防或改善与雌激素相关受体活性有关的一种或多种疾病或紊乱的症状。考虑到核激素受体ERRα的广泛活性范围，本文描述的能够调节ERRα活性的化合物，可用于治疗包括癌症、糖尿病、肥胖、高脂血症、关节炎、动脉粥样硬化、骨质疏松症、焦虑、抑郁症、帕金森病和阿尔茨海默病在内的一系列疾病状态。化学式（I）。取代基在权利要求中有定义。
• CO2 absorbing cost-effective ionic liquid for synthesis of commercially important alpha cyanoacrylic acids: A safe process for activation of cyanoacetic acid
  作者：Yogesh O. Sharma、Mariam S. Degani

  DOI：10.1039/b818540a

  日期：——

  Cost-effective and carbon dioxide absorbing ionic liquid, tri-(2-hydroxyethyl) ammonium acetate, was shown to perform multiple roles in Knoevenagel condensation. It acted as an environmentally benign solvent, as an activating catalyst for the less reactive cyanoacetic acid and also as a risk reduction medium for the unevenly generated large amount of CO2 gas for large scale reactions. The reaction was scaled up for multi-gram synthesis of commercially important alpha cyanoacrylic acids.

  一种具有成本效益且能吸收二氧化碳的离子液体三-(2-羟乙基)铵乙酸盐在Knoevenagel缩合反应中表现出多重作用。它作为一种环境友好的溶剂，作为反应性较低的氰基乙酸的活化催化剂，同时也作为大规模反应中对不均匀生成的大量二氧化碳气体的风险降低介质。该反应已扩展至多克规模，以合成商业上重要的α-氰基丙烯酸。
• Storage stable heat curable organosiloxane compositions containing a microencapsulated catalyst and method for preparing said catalyst
  申请人：DOW CORNING CORPORATION

  公开号：EP0550239A1

  公开（公告）日：1993-07-07

  The present invention provides microencapsulated hydrosilylation catalysts for one-part heat curable organosiloxane compositions. Compositions containing these exhibit long-term storage stability yet cure rapidly when heated above the melting point of the encapsulating polymer. At least a portion of these microcapsules are less than one micron in diameter and substantially all are less than about three microns in diameter. Compositions containing the preferred platinum group metals as catalysts are optically transparent. The microencapsulated curing catalysts of this invention are prepared by irradiating with UV light in the wavelength range of from 300 to 400 nanometers a solution containing (1) at least one of a specified group of photo-crosslinkable organosiloxane compounds derived from propargyl esters of carboxylic acids containing a terminal aromatic hydrocarbon radical and at least two ethylenically unsaturated carbon atoms and (2) a liquid or solubilized hydrosilylation catalyst.

  本发明为单组分热固化有机硅氧烷组合物提供了微胶囊水硅化催化剂。含有这些催化剂的组合物具有长期储存稳定性，而且在加热到封装聚合物熔点以上时可迅速固化。这些微胶囊中至少有一部分直径小于一微米，而基本上所有微胶囊的直径都小于约三微米。含有优选铂族金属作为催化剂的组合物是光学透明的。 本发明的微胶囊固化催化剂是通过用波长范围为 300 至 400 纳米的紫外线照射溶液制备的，该溶液含有(1)一组特定的可光交联有机硅氧烷化合物中的至少一种，这些化合物来源于含有一个末端芳香烃基和至少两个乙烯基不饱和碳原子的羧酸丙炔酯；(2)一种液态或溶解的加氢硅烷化催化剂。
• [EN] COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING POST TRAUMATIC STRESS DISORDER<br/>[FR] COMPOSITIONS ET METHODES DE DIAGNOSTIC ET DE TRAITEMENT DE TROUBLE DE STRESS POST-TRAUMATIQUE
  申请人：YISSUM RES DEV CO

  公开号：WO2006013561A2

  公开（公告）日：2006-02-09

  The present invention is of genes differentially expressed in post traumatic stress disorder (PTSD) affected subjects which can be used in determining predisposition to and/or diagnosing PTSD. Specifically, the present invention can be used in preventing and/or treating PTSD by regulating the expression level of the PTSD differentially expressed genes.

  本发明涉及创伤后应激障碍 (PTSD) 患者中差异表达的基因，这些基因可用于确定 PTSD 的易患性以及/或诊断 PTSD。具体而言，本发明可用于通过调节 PTSD 差异表达基因的表达水平来预防和/或治疗 PTSD。
• Lithium bromide as a new catalyst for carbon–carbon bond formation in the solid state
  作者：Dipak Prajapati、Kushal C. Lekhok、Jagir S. Sandhu、Anil C. Ghosh

  DOI：10.1039/p19960000959

  日期：——

  Lithium bromide catalyses the condensation of carbonyl compounds with active methylene compounds in the absence of solvent, to afford olefinic products in high yields.

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