1-[2-(2-Hydroxy-3-tetradecoxypropoxy)ethoxy]-3-tetradecoxypropan-2-ol | 217949-30-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油脂
• 英文名称: 1-[2-(2-Hydroxy-3-tetradecoxypropoxy)ethoxy]-3-tetradecoxypropan-2-ol
• 英文别名: 1-[2-(2-hydroxy-3-tetradecoxypropoxy)ethoxy]-3-tetradecoxypropan-2-ol
• CAS: 217949-30-9
• 化学式: C₃₆H₇₄O₆
• 分子量: 602.98
• InChiKey: FPVPKDOFZABACA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  11.7
• 重原子数：
  42
• 可旋转键数：
  37
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  77.4
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  1-[2-(2-Hydroxy-3-tetradecoxypropoxy)ethoxy]-3-tetradecoxypropan-2-ol 、 2,3,4,6-四-O-乙酰基-Β-D-吡喃半乳糖酰基-2,2,2-三氯代亚氨乙酸酯 在 三氟甲磺酸三甲基硅酯 、 sodium methylate 作用下， 以 二氯甲烷 、 甲醇 为溶剂， 生成 (2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-[1-tetradecoxy-3-[2-[3-tetradecoxy-2-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxypropoxy]ethoxy]propan-2-yl]oxyoxane-3,4,5-triol
  参考文献：
  名称：

  A Novel Type of Highly Effective Nonionic Gemini Alkyl O-Glucoside Surfactants: A Versatile Strategy of Design

  摘要：

  A novel type of highly effective gemini alkyl glucosides has, been rationally designed and synthesized The gemini surfactants have been readily prepared. by glycosylation of the gemini alkyl chains that are synthesized with regioselective ring-opening of ethylene glycol epoxides by the alkyl alcohols. The new gemini alkyl glucosides exhibit significantly better surface activity than the known results. Then rheological, DLS, and TEM studies have revealed the intriguing self-assembly behavior of the novel gemini surfactants. This study has proved the effectiveness of the design of gemini alkyl glucosides which is modular, extendable, and synthetically simple. The new gemini surfactants have great potential as nano carriers in drug and gene delivery.

  DOI：

  10.1021/la401569n
• 作为产物：
  描述：

  乙二醇二缩水甘油醚 、 十四醇 在 potassium hydroxide 作用下， 以 二甲基亚砜 为溶剂， 生成 1-[2-(2-Hydroxy-3-tetradecoxypropoxy)ethoxy]-3-tetradecoxypropan-2-ol
  参考文献：
  名称：

  A Novel Type of Highly Effective Nonionic Gemini Alkyl O-Glucoside Surfactants: A Versatile Strategy of Design

  摘要：

  A novel type of highly effective gemini alkyl glucosides has, been rationally designed and synthesized The gemini surfactants have been readily prepared. by glycosylation of the gemini alkyl chains that are synthesized with regioselective ring-opening of ethylene glycol epoxides by the alkyl alcohols. The new gemini alkyl glucosides exhibit significantly better surface activity than the known results. Then rheological, DLS, and TEM studies have revealed the intriguing self-assembly behavior of the novel gemini surfactants. This study has proved the effectiveness of the design of gemini alkyl glucosides which is modular, extendable, and synthetically simple. The new gemini surfactants have great potential as nano carriers in drug and gene delivery.

  DOI：

  10.1021/la401569n

文献信息

• A Novel Type of Highly Effective Nonionic Gemini Alkyl <i>O</i>-Glucoside Surfactants: A Versatile Strategy of Design
  作者：Songbai Liu、Ruocheng Sang、Shan Hong、Yujing Cai、Hua Wang

  DOI：10.1021/la401569n

  日期：2013.7.9

  A novel type of highly effective gemini alkyl glucosides has, been rationally designed and synthesized The gemini surfactants have been readily prepared. by glycosylation of the gemini alkyl chains that are synthesized with regioselective ring-opening of ethylene glycol epoxides by the alkyl alcohols. The new gemini alkyl glucosides exhibit significantly better surface activity than the known results. Then rheological, DLS, and TEM studies have revealed the intriguing self-assembly behavior of the novel gemini surfactants. This study has proved the effectiveness of the design of gemini alkyl glucosides which is modular, extendable, and synthetically simple. The new gemini surfactants have great potential as nano carriers in drug and gene delivery.