1,2,3-Trimethoxy-4-(phenylthio)benzene | 106592-91-0

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 1,2,3-Trimethoxy-4-(phenylthio)benzene
• 英文别名: 2,3,4-Trimethoxy-diphenylsulfid；1,2,3-Trimethoxy-4-phenylsulfanylbenzene
• CAS: 106592-91-0
• 化学式: C₁₅H₁₆O₃S
• 分子量: 276.356
• InChiKey: WXMPTKTZTOHSRT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  53
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1,2,3-Trimethoxy-4-(phenylthio)benzene 在 双氧水 作用下， 以 溶剂黄146 为溶剂， 生成 2,3,4-Trimethoxy-diphenylsulfon
  参考文献：
  名称：

  Horner,L.; Goewecke,S., Chemische Berichte, 1961, vol. 94, p. 1267 - 1276

  摘要：

  DOI：
• 作为产物：
  描述：

  1,2,3-三甲氧基苯 、 苯硫酚 在 [双(三氟乙酰氧基)碘]苯 作用下， 以 various solvent(s) 为溶剂， 反应 0.5h， 以88%的产率得到1,2,3-Trimethoxy-4-(phenylthio)benzene
  参考文献：
  名称：

  Novel and Direct Nucleophilic Sulfenylation and Thiocyanation of Phenol Ethers Using a Hypervalent Iodine(III) Reagent

  摘要：

  Novel and direct nucleophilic sulfenylation and thiocyanation of phenol ethers and related compounds (1) with the hypervalent iodine reagent, phenyliodine(III) bis(trifluoroacetate) (PIFA) have been developed. The reaction proceeded smoothly in 1,1,1,3,3,3-hexafluoro-2-propanol ((CF3)(2)-CHOH), a poorly nucleophilic and polar solvent. Various unsymmetrical diaryl sulfides and aryl thiocyanates, which could be applicable to the synthesis of various types of sulfur-containing aromatic compounds, were prepared in good yields. These reactions could be performed under mild conditions without heating or the use of strong Lewis acid catalysts.

  DOI：

  10.1021/jo00127a018

文献信息

• Novel and Direct Nucleophilic Sulfenylation and Thiocyanation of Phenol Ethers Using a Hypervalent Iodine(III) Reagent
  作者：Yasuyuki Kita、Takeshi Takada、Sachiko Mihara、Brendan A. Whelan、Hirofumi Tohma

  DOI：10.1021/jo00127a018

  日期：1995.11

  Novel and direct nucleophilic sulfenylation and thiocyanation of phenol ethers and related compounds (1) with the hypervalent iodine reagent, phenyliodine(III) bis(trifluoroacetate) (PIFA) have been developed. The reaction proceeded smoothly in 1,1,1,3,3,3-hexafluoro-2-propanol ((CF3)(2)-CHOH), a poorly nucleophilic and polar solvent. Various unsymmetrical diaryl sulfides and aryl thiocyanates, which could be applicable to the synthesis of various types of sulfur-containing aromatic compounds, were prepared in good yields. These reactions could be performed under mild conditions without heating or the use of strong Lewis acid catalysts.
• Horner,L.; Goewecke,S., Chemische Berichte, 1961, vol. 94, p. 1267 - 1276
  作者：Horner,L.、Goewecke,S.

  DOI：——

  日期：——