N-acetyloxazolidine | 3672-60-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: N-acetyloxazolidine
• 英文别名: 3-acetyl-1,3-oxazolidine；3-acetyloxazolidine；N-Acetyl-oxazolidin；Oxazolidine, 3-acetyl-；1-(1,3-oxazolidin-3-yl)ethanone
• CAS: 3672-60-4
• 化学式: C₅H₉NO₂
• 分子量: 115.132
• InChiKey: BLQLHNKKPBHCIF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2934999090

反应信息

• 作为反应物：
  描述：

  N-acetyloxazolidine 在 二叔丁基过氧化物 作用下， 以68%的产率得到N-ethyl-N-acetylformamide
  参考文献：
  名称：

  Lapshova, A. A.; Zorin, V. V.; Zlot-skii, S. S., Journal of Organic Chemistry USSR (English Translation), 1982, vol. 18, p. 588 - 589

  摘要：

  DOI：
• 作为产物：
  描述：

  聚合甲醛 、 N-乙酰乙醇胺 在 对甲苯磺酸 作用下， 以 四氢呋喃 、 甲苯 为溶剂， 反应 1.0h， 以97%的产率得到N-acetyloxazolidine
  参考文献：
  名称：

  First Synthetic Method for the Preparation of 6-Unsubstituted-2,3-dihydro-1,3-oxazin-4-ones

  摘要：

  The first synthetic pathway to synthesize 6-unsubstituted-2,3-dihydro-1,3-oxazin-4-ones is described. The alpha-formylation of the starting amide and the cyclization of the alpha-formylamide with a desired aldehyde under acidic conditions gave compounds 5a-h (R = nPr, iPr, cPr, cHex, Ph, CH(2)Ph, nHex, and R(1) = H, Me). This strategy was used with little modification for the preparation of new monocyclic organic nitrates such as 2a-c (2a (R = Ph, R(1) = H, and R(2) = H), 2b (R = Ph, R(1) = H, and R(2) = Me), and 2c (R = H, R(1) = Ph, and R(2) = H).

  DOI：

  10.1021/jo952118h

文献信息

• A novel bicyclic system, 1,6-diaza-3,8-dioxabicyclo[4.4.1]undecane
  作者：R. G. Kostyanovsky、Yu. I. El'natanov、O. N. Krutius、I. I. Chervin、H. Zaddach、K. F. Koehler

  DOI：10.1007/bf00695844

  日期：1994.2

  Condensation of monoethanolamine with formaldehyde affords 1,6-diaza-3,8-dioxabicyclo[4.4.1]undecane andN,N′-methylene-bis(oxazolidine) in a ratio of 1∶8.

  单乙醇胺与甲醛缩合得到1,6-二氮杂-3,8-二氧杂双环[4.4.1]十一烷和N,N'-亚甲基-双(恶唑烷)的比例为1∶8。
• Heterocyclic deformations from molecular enlargement
  作者：Joseph B. Lambert、Stephen M. Wharry

  DOI：10.1021/jo00141a017

  日期：1982.9
• LAPSHOVA, A. A.;ZORIN, V. V.;ZLOTSKIJ, S. S.;RAXMANKULOV, D. L., ZH. ORGAN. XIMII, 1982, 18, N 3, 677-678
  作者：LAPSHOVA, A. A.、ZORIN, V. V.、ZLOTSKIJ, S. S.、RAXMANKULOV, D. L.

  DOI：——

  日期：——
• LAMBERT, J. B.;WHARRY, S. M., J. ORG. CHEM., 1982, 47, N 20, 3890-3893
  作者：LAMBERT, J. B.、WHARRY, S. M.

  DOI：——

  日期：——
• First Synthetic Method for the Preparation of 6-Unsubstituted-2,3-dihydro-1,3-oxazin-4-ones
  作者：Giorgio Bertolini、Mario Aquino、Francesco Ferrario、Gianfranco Pavich、Andrea Zaliani、Alberto Sala

  DOI：10.1021/jo952118h

  日期：1996.1.1

  The first synthetic pathway to synthesize 6-unsubstituted-2,3-dihydro-1,3-oxazin-4-ones is described. The alpha-formylation of the starting amide and the cyclization of the alpha-formylamide with a desired aldehyde under acidic conditions gave compounds 5a-h (R = nPr, iPr, cPr, cHex, Ph, CH(2)Ph, nHex, and R(1) = H, Me). This strategy was used with little modification for the preparation of new monocyclic organic nitrates such as 2a-c (2a (R = Ph, R(1) = H, and R(2) = H), 2b (R = Ph, R(1) = H, and R(2) = Me), and 2c (R = H, R(1) = Ph, and R(2) = H).