二硫代乙酸乙酯 - CAS号 870-73-5

物化性质

沸点：

61 °C/23 mmHg (lit.)
密度：

1.048 g/mL at 25 °C (lit.)
闪点：

115 °F
稳定性/保质期：

在常温常压下稳定。

计算性质

辛醇/水分配系数(LogP)：

1.6
重原子数：

6
可旋转键数：

2
环数：

0.0
sp3杂化的碳原子比例：

0.75
拓扑面积：

57.4
氢给体数：

0
氢受体数：

2

安全信息

危险等级：

3.2
危险品标志：

Xi
安全说明：

S26
危险类别码：

R10,R36/37/38
海关编码：

2930909090
包装等级：

III
危险类别：

3.2
WGK Germany：

3
危险标志：

GHS02,GHS07
危险品运输编号：

UN 3272
危险性描述：

H226,H315,H319,H335
危险性防范说明：

P261,P305 + P351 + P338
储存条件：

常温、避光、存放在通风干燥处。

SDS

SDS：9932bc62740a93b9d86fbbea2febaefe

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SECTION 1: Identification of the substance/mixture and of the company/undertaking
Product identifiers
Product name : Ethyl dithioacetate
REACH No. : A registration number is not available for this substance as the substance
or its uses are exempted from registration, the annual tonnage does not
require a registration or the registration is envisaged for a later
registration deadline.
CAS-No. : 870-73-5
Relevant identified uses of the substance or mixture and uses advised against
Identified uses : Laboratory chemicals, Manufacture of substances

SECTION 2: Hazards identification
Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008
Flammable liquids (Category 3), H226
Skin irritation (Category 2), H315
Eye irritation (Category 2), H319
Specific target organ toxicity - single exposure (Category 3), H335
For the full text of the H-Statements mentioned in this Section, see Section 16.
Classification according to EU Directives 67/548/EEC or 1999/45/EC
Xi Irritant R10, R36/37/38
For the full text of the R-phrases mentioned in this Section, see Section 16.
Label elements
Labelling according Regulation (EC) No 1272/2008
Pictogram
Signal word Warning
Hazard statement(s)
H226 Flammable liquid and vapour.
H315 Causes skin irritation.
H319 Causes serious eye irritation.
H335 May cause respiratory irritation.
Precautionary statement(s)
P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove
contact lenses, if present and easy to do. Continue rinsing.
Supplemental Hazard none
Statements
Other hazards - none

SECTION 3: Composition/information on ingredients
Substances
Formula : C4H8S2
Molecular Weight : 120,24 g/mol
CAS-No. : 870-73-5
EC-No. : 212-801-4
Hazardous ingredients according to Regulation (EC) No 1272/2008
Component Classification Concentration
Ethyl dithioacetate
Flam. Liq. 3; Skin Irrit. 2; Eye -
Irrit. 2; STOT SE 3; H226,
H315, H319, H335
Hazardous ingredients according to Directive 1999/45/EC
Component Classification Concentration
Ethyl dithioacetate
Xi, R10 - R36/37/38 -
For the full text of the H-Statements and R-Phrases mentioned in this Section, see Section 16

SECTION 4: First aid measures
Description of first aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact
Wash off with soap and plenty of water. Consult a physician.
In case of eye contact
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
If swallowed
Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with
water. Consult a physician.
Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in
section 11
Indication of any immediate medical attention and special treatment needed
no data available

SECTION 5: Firefighting measures
Extinguishing media
Suitable extinguishing media
For small (incipient) fires, use media such as "alcohol" foam, dry chemical, or carbon dioxide. For large
fires, apply water from as far as possible. Use very large quantities (flooding) of water applied as a mist or
spray; solid streams of water may be ineffective. Cool all affected containers with flooding quantities of
water.
Special hazards arising from the substance or mixture
Carbon oxides, Sulphur oxides
Advice for firefighters
Wear self contained breathing apparatus for fire fighting if necessary.
Further information
Use water spray to cool unopened containers.

SECTION 6: Accidental release measures
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid breathing vapours, mist or gas. Ensure adequate ventilation.
Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to
form explosive concentrations. Vapours can accumulate in low areas.
For personal protection see section 8.
Environmental precautions
Prevent further leakage or spillage if safe to do so. Do not let product enter drains.
Methods and materials for containment and cleaning up
Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and
place in container for disposal according to local regulations (see section 13).
Reference to other sections
For disposal see section 13.

SECTION 7: Handling and storage
Precautions for safe handling
Avoid contact with skin and eyes. Avoid inhalation of vapour or mist.
Keep away from sources of ignition - No smoking.Take measures to prevent the build up of electrostatic
charge.
For precautions see section 2.2.
Conditions for safe storage, including any incompatibilities
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are
opened must be carefully resealed and kept upright to prevent leakage.
Store under inert gas. Air sensitive.
Specific end use(s)
A part from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection
Control parameters
Components with workplace control parameters
Exposure controls
Appropriate engineering controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and
at the end of workday.
Personal protective equipment
Eye/face protection
Face shield and safety glasses Use equipment for eye protection tested and approved under
appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique
(without touching glove's outer surface) to avoid skin contact with this product. Dispose of
contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.
The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and
the standard EN 374 derived from it.
Body Protection
impervious clothing, Flame retardant antistatic protective clothing, The type of protective
equipment must be selected according to the concentration and amount of the dangerous
substance at the specific workplace.
Respiratory protection
Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator
with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup
to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air
respirator. Use respirators and components tested and approved under appropriate government
standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

SECTION 9: Physical and chemical properties
Information on basic physical and chemical properties
a) Appearance Form: liquid
b) Odour Stench.
c) Odour Threshold no data available
d) pH no data available
e) Melting point/freezing no data available
point
f) Initial boiling point and 61 °C at 31 hPa
boiling range
g) Flash point 46 °C - closed cup
h) Evapouration rate no data available
i) Flammability (solid, gas) no data available
j) Upper/lower no data available
flammability or
explosive limits
k) Vapour pressure no data available
l) Vapour density no data available
m) Relative density 1,048 g/mL at 25 °C
n) Water solubility no data available
o) Partition coefficient: n- no data available
octanol/water
p) Auto-ignition no data available
temperature
q) Decomposition no data available
temperature
r) Viscosity no data available
s) Explosive properties no data available
t) Oxidizing properties no data available
Other safety information
no data available

SECTION 10: Stability and reactivity
Reactivity
no data available
Chemical stability
Stable under recommended storage conditions.
Possibility of hazardous reactions
no data available
Conditions to avoid
Heat, flames and sparks.
Incompatible materials
Strong oxidizing agents
Hazardous decomposition products
Other decomposition products - no data available
In the event of fire: see section 5

SECTION 11: Toxicological information
Information on toxicological effects
Acute toxicity
no data available
Skin corrosion/irritation
no data available
Serious eye damage/eye irritation
no data available
Respiratory or skin sensitisation
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
IARC: No component of this product present at levels greater than or equal to 0.1% is identified as
probable, possible or confirmed human carcinogen by IARC.
Reproductive toxicity
no data available
Specific target organ toxicity - single exposure
Inhalation - May cause respiratory irritation.
Specific target organ toxicity - repeated exposure
no data available
Aspiration hazard
no data available
Additional Information
RTECS: Not available
Nausea, Headache, Vomiting, To the best of our knowledge, the chemical, physical, and toxicological
properties have not been thoroughly investigated.

SECTION 12: Ecological information
Toxicity
no data available
Persistence and degradability
no data available
Bioaccumulative potential
no data available
Mobility in soil
no data available
Results of PBT and vPvB assessment
PBT/vPvB assessment not available as chemical safety assessment not required/not conducted
Other adverse effects
no data available

SECTION 13: Disposal considerations
Waste treatment methods
Product
Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting
as this material is highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal
company. Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging
Dispose of as unused product.

SECTION 14: Transport information
UN number
ADR/RID: 3272 IMDG: 3272 IATA: 3272
UN proper shipping name
ADR/RID: ESTERS, N.O.S. (Ethyl dithioacetate)
IMDG: ESTERS, N.O.S. (Ethyl dithioacetate)
IATA: Esters, n.o.s. (Ethyl dithioacetate)
Transport hazard class(es)
ADR/RID: 3 IMDG: 3 IATA: 3
Packaging group
ADR/RID: III IMDG: III IATA: III
Environmental hazards
ADR/RID: no IMDG Marine pollutant: no IATA: no
Special precautions for user
no data available

SECTION 15: Regulatory information
This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.
Safety, health and environmental regulations/legislation specific for the substance or mixture
no data available
Chemical Safety Assessment
For this product a chemical safety assessment was not carried out

SECTION 16: Other information
Full text of H-Statements referred to under sections 2 and 3.
Eye Irrit. Eye irritation
Flam. Liq. Flammable liquids
H226 Flammable liquid and vapour.
H315 Causes skin irritation.
H319 Causes serious eye irritation.
H335 May cause respiratory irritation.
Skin Irrit. Skin irritation
STOT SE Specific target organ toxicity - single exposure
Full text of R-phrases referred to under sections 2 and 3
Xi Irritant
R10 Flammable.
R36/37/38 Irritating to eyes, respiratory system and skin.
Further information
Copyright 2013 Co. LLC. License granted to make unlimited paper copies for internal use
only.
The above information is believed to be correct but does not purport to be all inclusive and shall be
used only as a guide. The information in this document is based on the present state of our knowledge
and is applicable to the product with regard to appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Corporation and its Affiliates shall not be held
liable for any damage resulting from handling or from contact with the above product. See
and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

上下游信息

反应信息

作为反应物：

描述：

二硫代乙酸乙酯在 sodium hydroxide 、四丁基硫酸氢铵作用下，以二氯甲烷为溶剂，反应 7.0h，以99%的产率得到硫代乙酸S-乙酯

参考文献：

名称：

一种异常温和的相转移催化方法，可将硫代羰基化合物转化为羰基化合物

摘要：

可以通过在相转移条件下用氢氧化钠处理将硫代酮，二硫代酯，硫代酰胺和硫脲的硫代羰基转化为羰基官能团。

DOI：

10.1016/s0040-4039(00)85234-x
作为产物：

描述：

硫代乙酸S-乙酯在 tetraphosphorus decasulfide 、碳酸氢钠作用下，生成二硫代乙酸乙酯

参考文献：

名称：

A General Procedure for the Conversion of a Carbonyl Group into a Thione Group with Tetraphosphorus Decasulfide

摘要：

DOI：

10.1055/s-1973-22150

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文献信息

Oxazolidinone compounds and compositions, and methods of using the same

申请人：Pharmacia & Upjohn Company

公开号：US06441005B1

公开（公告）日：2002-08-27

Oxazolidinones and methods for their synthesis are provided. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. Oxazolidinones as disclosed herein can be readily synthesized and used in a variety of applications including use as antimicrobial agents. In one embodiment, a variety of thioamidomethyloxazolidinones and methods for their synthesis and use are provided.

提供了噁唑烷酮及其合成方法。此外，还提供了制备生物活性噁唑烷酮的方法，以及包含噁唑烷酮的药用合成物。本文所披露的噁唑烷酮可以很容易地合成并用于各种应用，包括用作抗微生物剂。在一个实施例中，提供了各种硫代氨基甲氧噁唑烷酮及其合成和使用方法。
Oxazolidinone antibacterial agents having a thiocarbonyl functionality

申请人：Pharmacia and Upjohn Company

公开号：US06342513B1

公开（公告）日：2002-01-29

The present invention provides compounds of Formula 1: or pharmaceutical acceptable salts thereof wherein A, G and R1 are as defined in the claims which are antibacterial agents.

本发明提供了式1化合物：或药物可接受的盐，其中A，G和R1如权利要求中所定义，它们是抗菌剂。
Reactions of deprotonated sulphur-donor complexes of pentacarbonylchromium(0) with carbon disulphide or carbon diselenide

作者：Helgard G. Raubenheimer、Simon Lotz、Gert J. Kruger、Antonie van A. Lombard、Joey C. Viljoen

DOI：10.1016/0022-328x(87)85194-x

日期：1987.12

selective in its reactions with all three coordinated carbanions and the diethyltriselenocarbonate complex [Cr(CO)5SeC(SeEt)2}] (II) was isolated upon further alkylation. The product from uncoordinated deprotonated 1,3-dithiane and CS2 was trapped by [Ti(η-Cp)2Cl2] (Cp = cyclopentadienyl) to give the four-membered chelate [Ti(η5-Cp)2S2CC(SR1)SR2}] (R1R2 = (CH2)3 (III) or R1 = R2 = Ph (IV)). During the

用[Et 3 O] [BF 4 ]将α-硫代碳负离子[Cr（CO）5 S（CH 2）（3 S）CH] -与CS 2之间的加合物烷基化，以生成螯合物fac- [Cr（ CO）3（S [CH 2 ] 3 SC（C [（S）SET）2 ]（I）由2,2- dithi [CR（CO）5 - （SCNMe 2 }] - ，得到三硫代碳酸酯复合物， [Cr（CO）5 SC（SEt）2 }]（VIII）。β-硫代原型与CS 2反应，烷基化得到三种硫酮配合物[Cr（CO）5SC（Me）CHC（SEt）2 }]（X），[Cr（CO）5 SC（SEt）2 }]（VIII）和[Cr（CO）5 S C（SEt）CH ＝ C（SEt）2 }]（XII）。CSe 2在与所有三个配位碳负离子的反应中选择性较低，并且进一步烷基化后，分离出二乙基三硒碳酸盐络合物[Cr（CO）5 SeC（SeEt）2
Positive allosteric modulators of the nicotinic acetylcholine receptor

申请人：——

公开号：US20030236287A1

公开（公告）日：2003-12-25

The invention provides compounds of Formula I: 1 These compounds may be in the form of pharmaceutical salts or compositions, may be in pure enantiomeric form or racemic mixtures, and are useful in pharmaceuticals used to treat diseases or conditions in which &agr;7 nAChR is known to be involved.

这项发明提供了I式化合物：这些化合物可以是药用盐或组合物的形式，可以是纯对映体形式或混合物，对治疗已知涉及α7 nAChR的疾病或症状的药物非常有用。
Diastereofacial selectivity via aldol reactions using ethyl dithioacetate and ethyl dithiopropionate enolates

作者：A.I. Meyers、Robert D. Walkup

DOI：10.1016/s0040-4020(01)96754-7

日期：1985.1

The lithium enolate of ethyl dithioacetate reacts with α-methyl aldehydes to yield the aldol products in which the syn configuration in the positions β and γ to the thiocarbonyl of the product is favored over the anti configuration. This selectivity is solvent-dependent, and is enhanced at lower temperatures. In most cases, syn:anti product ratios obtained under these conditions varied from 57:43 to

二硫代乙酸乙酯的烯醇锂与α-甲基醛反应生成醛醇产物，其中相对于抗构象，在产物的硫代羰基的β和γ位的顺式构象更有利。该选择性取决于溶剂，并且在较低的温度下会提高。在大多数情况下，根据α-甲基醛的结构，在这些条件下获得的顺式：反式产物比率从57:43到> 99：1不等。当使二硫代丙酸乙酯的烯醇锂与α-甲基醛反应时，在产物混合物中仅检测到四种可能的非对映异构体中的两种。

二硫代乙酸乙酯 | 870-73-5

物质功能分类

分子结构分类

物化性质

计算性质

安全信息

SDS

上下游信息

反应信息

文献信息

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