二甲基硫代氨基甲酸 O-新戊基酯 | 21299-37-6

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫代羰基化合物
• 中文名称: 二甲基硫代氨基甲酸 O-新戊基酯
• 中文别名: 二甲基硫代氨基甲酸O-新戊基酯
• 英文名称: dimethyl-thiocarbamic acid O-neopentyl ester
• 英文别名: Dimethyl-thiocarbamidsaeure-O-neopentylester；Carbamic acid, O-neopentyl ester；O-(2,2-dimethylpropyl) N,N-dimethylcarbamothioate
• CAS: 21299-37-6
• 化学式: C₈H₁₇NOS
• 分子量: 175.295
• InChiKey: JBNZARIEABXZLA-UHFFFAOYSA-N

物化性质

• 沸点：
  193.4±23.0 °C(Predicted)
• 密度：
  0.977±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  44.6
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2930909090

反应信息

• 作为产物：
  描述：

  neopentyloxythiocarbonylmercapto-acetic acid 、 二甲胺 在 sodium hydroxide 作用下， 生成 二甲基硫代氨基甲酸 O-新戊基酯
  参考文献：
  名称：

  Aggressive Metastatic Follicular Thyroid Carcinoma with Anaplastic Transformation Arising from a Long-Standing Goiter in a Patient with Pendred's Syndrome

  摘要：

  In this article we describe detailed pathological and molecular genetics studies in a consanguineous kindred with Pendred's syndrome. The index patient was a 53-year-old female patient with congenital deafness and goiter. Her parents were first-degree cousins. She had a large goiter (150 g) that had been present since childhood. One of her sisters and a niece are also deaf and have goiter as well. The presence of Pendred's syndrome was confirmed by a positive perchlorate test and the demonstration of a Mondini malformation. Thyroid function tests (under levothyroxine [LT4] therapy) were in the euthyroid range with a thyrotropin [TSH] level of 2.8 muU/mL (0.2-3.2), a serum total thyroxine (T-4) of 90 nmol/L (54-142), and a serum total triiodothyronine (T-3) of 2.7 nmol/L (0.8-2.4). Total thyroidectomy was performed, and the mass in the right lobe was found to have invaded adjacent tissues. The histopathological findings were consistent with a follicular carcinoma with areas of anaplastic transformation and lung metastasis. The patient was treated twice with 100 mCi (131)iodine (3,700 MBq) and received suppressive doses of LT4. Postoperatively, the serum thyroglobulin (Tg) levels remained markedly elevated (2,352 to 41,336 ng/mL). The patient died of a sudden severe episode of hemoptysis. Sequence analysis of the PDS gene performed with DNA from the two relatives with Pendred's syndrome revealed the presence of a deletion of thymidine 279 in exon 3, a point mutation that results in a frameshift and a premature stop codon at codon 96 in the pendrin molecule. We concluded that prolonged TSH stimulation because of iodine deficiency or dyshormonogenesis in combination with mutations of oncogenes and/or tumor suppressor genes, may result in the development of follicular thyroid carcinomas that undergo transformation into anaplastic cancers. It is likely that these pathogenetic mechanisms have been involved in the development of aggressive metastatic thyroid cancer in this unusual patient with Pendred's syndrome.

  DOI：

  10.1089/105072501753211073

文献信息

• Preparation of olefins by pyrolysis of O-alkyldimethythiocarbamates
  作者：Melvin S. Newman、Fredrick W. Hetzel

  DOI：10.1021/jo01263a083

  日期：1969.11