2-[[4-[(2-Carboxyphenoxy)methyl]phenyl]methoxy]benzoic acid | 17351-69-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[[4-[(2-Carboxyphenoxy)methyl]phenyl]methoxy]benzoic acid
• CAS: 17351-69-8
• 化学式: C₂₂H₁₈O₆
• 分子量: 378.381
• InChiKey: WPZRQMWCQRSQTQ-UHFFFAOYSA-N

物化性质

• 熔点：
  238-240 °C
• 沸点：
  613.3±45.0 °C(Predicted)
• 密度：
  1.332±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  28
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  93.1
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2-[[4-[(2-Carboxyphenoxy)methyl]phenyl]methoxy]benzoic acid 在 氯化亚砜 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 生成 2-[[4-[(2-carbonochloridoylphenoxy)methyl]phenyl]methoxy]benzoyl chloride
  参考文献：
  名称：

  Synthesis, characterization and ion transportation studies of some novel cyclophane amides

  摘要：

  Various novel cyclophane amides with a large cavity have been synthesized. The structures of cyclophane amides 14 and 15 were resolved using XRD studies. Cyclophane amide 28 shows a shift in lambda(max) in the UV/Vis. spectra when treated with Cu (II) ion as well as with Ph(II) ion. Ion transportation studies were carried out with cyclophane amide 14 which proved that the Na+ ion passes through the cavity while K+ ions are retained. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2005.03.064
• 作为产物：
  描述：

  1,4-bis(o-carbomethoxyphenoxymethyl)benzene 在 氢氧化钾 作用下， 以 乙醇 为溶剂， 以95%的产率得到2-[[4-[(2-Carboxyphenoxy)methyl]phenyl]methoxy]benzoic acid
  参考文献：
  名称：

  Synthesis, characterization and ion transportation studies of some novel cyclophane amides

  摘要：

  Various novel cyclophane amides with a large cavity have been synthesized. The structures of cyclophane amides 14 and 15 were resolved using XRD studies. Cyclophane amide 28 shows a shift in lambda(max) in the UV/Vis. spectra when treated with Cu (II) ion as well as with Ph(II) ion. Ion transportation studies were carried out with cyclophane amide 14 which proved that the Na+ ion passes through the cavity while K+ ions are retained. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2005.03.064

文献信息

• EDC/DMAP-mediated direct condensation of dicarboxylic acids and diols: A concise synthesis of extra large polyether macrocyclic lactones and their X-ray structures
  作者：Naveen、Srinivasarao Arulananda Babu

  DOI：10.1016/j.tetlet.2016.11.046

  日期：2016.12

  1-ol), 2,2′-oxybis(ethan-1-ol)). The condensation reactions of dicarboxylic acids with diols afforded 1:1 (18-24-membered) and 2:2 (36–48-membered) polyether macrocyclic lactones. The synthesis of small and extra-large polyether macrocyclic lactones was accomplished without using a template and relatively simple reaction conditions. All the reported macrocyclic lactones were separated by column chromatography

  我们报告了EDC / DMAP介导的二元羧酸与二醇的直接缩合反应，以及合成新类的18-48元，小型和超大型聚醚大环内酯。通过使用各种通过脂肪族，聚醚和芳香族连接基连接的二元羧酸和不同的二醇（例如，（Z）-丁-2-烯-1,4-二醇，丁-2-炔-1,4-二醇，2,2'-硫代双（乙烷-1-醇），2,2'-（苄基氮杂二基）双（ ethan-1-ol），2,2'-oxybis（ethan-1-ol））。二元羧酸与二醇的缩合反应提供了1：1（18-24元）和2：2（36-48元）的聚醚大环内酯。在不使用模板和相对简单的反应条件的情况下，完成了小型和超大型聚醚大环内酯的合成。通过柱色谱分离所有报道的大环内酯，并通过1 H，13 C NMR和HRMS分析进行表征。还报道了代表性的聚醚大环内酯的固态（X射线）结构。
• Synthesis, characterization, and anti-bacterial efficacy of some novel cyclophane amide
  作者：Perumal Rajakumar、A. Mohammed Abdul Rasheed、P.M. Balu、K. Murugesan

  DOI：10.1016/j.bmc.2006.07.020

  日期：2006.11

  Synthesis of macrocyclic di, tetra- and hexaamides with aza and oxy linkages has been achieved and the inhibitory activity of cyclophane amides against human pathogenic bacteria well documented. (c) 2006 Elsevier Ltd. All rights reserved.
• Synthesis, characterization and ion transportation studies of some novel cyclophane amides
  作者：Perumal Rajakumar、A. Mohammed Abdul Rasheed

  DOI：10.1016/j.tet.2005.03.064

  日期：2005.5

  Various novel cyclophane amides with a large cavity have been synthesized. The structures of cyclophane amides 14 and 15 were resolved using XRD studies. Cyclophane amide 28 shows a shift in lambda(max) in the UV/Vis. spectra when treated with Cu (II) ion as well as with Ph(II) ion. Ion transportation studies were carried out with cyclophane amide 14 which proved that the Na+ ion passes through the cavity while K+ ions are retained. (c) 2005 Elsevier Ltd. All rights reserved.