N-[5-(三氟甲基）-2-吡啶基]-N-甲基肼 | 163620-24-4

• 物质功能分类: 医药中间体 - 杂环化合物 - 吡啶类化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: N-[5-(三氟甲基）-2-吡啶基]-N-甲基肼
• 中文别名: N-[5-(三氟甲基)-2-吡啶基]-N-甲基肼；2-(1-甲基肼基)-5-(三氟甲基)吡啶；1-甲基-1-[5-(三氟甲基)-2-吡啶]肼
• 英文名称: N-methyl-N-(5-trifluoromethyl-pyridin-2-yl)-hydrazine
• 英文别名: 1-[5-trifluoromethylpyrid-2-yl]-1-methyl hydrazine；2-(1-methylhydrazinyl)-5-(trifluoromethyl)pyridine；2-(1-methylhydrazino)-5-(trifluoromethyl)pyridine；1-methyl-1-[5-(trifluoromethyl)pyridin-2-yl]hydrazine
• CAS: 163620-24-4
• 化学式: C₇H₈F₃N₃
• mdl: MFCD00052297
• 分子量: 191.156
• InChiKey: LZYILLLQHBJCFB-UHFFFAOYSA-N

物化性质

• 熔点：
  52 °C
• 沸点：
  257℃
• 密度：
  1.352
• 闪点：
  110℃

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.285
• 拓扑面积：
  42.2
• 氢给体数：
  1
• 氢受体数：
  6

安全信息

• 危险品标志：
  Xi
• 安全说明：
  S26,S36/37/39
• 危险类别码：
  R20/21/22
• 海关编码：
  2933990090
• 危险标志：
  GHS06
• 危险性描述：
  H301,H319
• 危险性防范说明：
  P301 + P310,P305 + P351 + P338

SDS

Name:	1-Methyl-1-[5-(trifluoromethyl)-2-1-Methyl-1-[5-(trifluoromethyl)-2- Material Safety Data Sheet
Synonym:
CAS:	163620-24-4

Section 1 - Chemical Product MSDS Name:1-Methyl-1-[5-(trifluoromethyl)-2-1-Methyl-1-[5-(trifluoromethyl)-2- Material Safety Data Sheet
Synonym:

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Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
163620-24-4	1-Methyl-1-[5-(trifluoromethyl)-2-pyri	97%	unlisted

Hazard Symbols: XN
Risk Phrases: 20/21/22

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Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Harmful by inhalation, in contact with skin and if swallowed.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation. Harmful if absorbed through the skin.
Ingestion:
Harmful if swallowed. May cause irritation of the digestive tract.
Inhalation:
Harmful if inhaled. May cause respiratory tract irritation.
Chronic:
Not available.

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Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
Get medical aid. Wash mouth out with water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:

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Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.

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Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container.

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Section 7 - HANDLING and STORAGE
Handling:
Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Storage:
Store in a cool, dry place. Store in a tightly closed container.

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Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 163620-24-4: Personal Protective Equipment Eyes: Not available.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

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Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Solid
Color: dark
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 52 - 55 deg C
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature: Not available.
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C7H8F3N3
Molecular Weight: 191

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Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Not available.
Conditions to Avoid:
Incompatible materials.
Incompatibilities with Other Materials:
Strong oxidizing agents, acids.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide, fluorine, hydrogen fluoride gas.
Hazardous Polymerization: Has not been reported

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Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 163620-24-4 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
1-Methyl-1-[5-(trifluoromethyl)-2-pyridyl]hydrazine - Not listed by ACGIH, IARC, or NTP.

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Section 12 - ECOLOGICAL INFORMATION

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Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

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Section 14 - TRANSPORT INFORMATION

IATA
Shipping Name: TOXIC SOLID, ORGANIC, N.O.S.*
Hazard Class: 6.1
UN Number: 2811
Packing Group: III
IMO
Shipping Name: TOXIC SOLID, ORGANIC, N.O.S.
Hazard Class: 6.1
UN Number: 2811
Packing Group: III
RID/ADR
Shipping Name: TOXIC SOLID, ORGANIC, N.O.S.
Hazard Class: 6.1
UN Number: 2811
Packing group: III

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Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XN
Risk Phrases:
R 20/21/22 Harmful by inhalation, in contact with
skin and if swallowed.
Safety Phrases:
S 36/37 Wear suitable protective clothing and
gloves.
WGK (Water Danger/Protection)
CAS# 163620-24-4: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 163620-24-4 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 163620-24-4 is not listed on the TSCA inventory.
It is for research and development use only.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  N-[5-(三氟甲基）-2-吡啶基]-N-甲基肼 、 4-(4-formyl-2-thiazolyl)-1-[2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl]piperidine 在 silica gel 、 乙酸乙酯 、 正己烷 作用下， 以 乙醇 为溶剂， 反应 24.0h， 生成 2-(1-{[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl}piperidin-4-yl)-1,3-thiazole-4-carbaldehyde methyl[5-(trifluoromethyl)pyridin-2-yl]hydrazone
  参考文献：
  名称：

  Thiazolyl oxime ethers and hydrazones as crop protection agents

  摘要：

  本发明涉及公式（I）的噻唑氧肟醚和肼酮，其中符号A，L1，L2，Y，W，X，R1，R2，R3，R4，R5，R6和R7具有描述中所给出的含义，以及其农药活性盐，以及用于控制植物病原真菌的使用方法，以及制备公式（I）化合物的方法。

  公开号：

  US20100190828A1
• 作为产物：
  描述：

  2-氯-5-三氟甲基吡啶 、 甲基肼 在 sodium hydroxide 作用下， 以94%的产率得到N-[5-(三氟甲基）-2-吡啶基]-N-甲基肼
  参考文献：
  名称：

  Photochromic compounds

  摘要：

  本发明涉及一种一般式为（I）的螺环（吲哚啉）氧杂环化合物，其中R.sub.1表示公式--NR.sub.2 R.sub.3的基团，其中R.sub.2和R.sub.3分别表示独立的烷基或碳环基，优选芳基或杂环基，或R.sub.2和R.sub.3与它们连接的氮原子一起表示具有一个或多个杂原子的杂环环，该环可能选择地携带至少一个选自烷基、芳基或杂芳基的取代基; --X--选择自--O--、--S--、--Se--、--NH--或--NR--，其中R表示烷基，环A是一个碳环或杂环环，可以选择地用公式R.sub.8所定义的基团取代，或者可以选择地与一个碳环或杂环环融合; R.sub.4-R.sub.8如本说明书所定义。本发明的螺环（吲哚啉）氧杂环化合物可用作光致变色材料。

  公开号：

  US05833885A1

文献信息

• Hydrazide and alkoxyamide angiogenesis inhibitors
  申请人：——

  公开号：US20020002152A1

  公开（公告）日：2002-01-03

  Compounds having the formula 1 are methionine aminopeptidase type 2 (MetAP2) inhibitors and are useful for inhibiting angiogenesis. Also disclosed are MetAP2-inhibiting compositions and methods of inhibiting angiogenesis in a mammal.

  具有以下化学式的化合物是蛋氨酸氨肽酶2型（MetAP2）抑制剂，对抑制血管生成有用。还公开了抑制MetAP2的组合物和在哺乳动物中抑制血管生成的方法。
• [EN] HYDRAZIDE AND ALKOXYAMIDE ANGIOGENESIS INHIBITORS<br/>[FR] INHIBITEURS D'ANGIOGENESE A BASE D'HYDRAZIDE ET D'ALCOXYAMIDE
  申请人：ABBOTT LAB

  公开号：WO2001079157A1

  公开（公告）日：2001-10-25

  Compounds having the formula are methionine aminopeptidase type 2 (MetAP2) inhibitors and are useful for inhibiting angiogenesis. Also disclosed are MetAP2-inhibiting compositions and methods of inhibiting angiogenesis in a mammal.

  具有公式的化合物是蛋氨酸氨肽酶2型（MetAP2）抑制剂，并且对于抑制血管生成具有用处。还披露了MetAP2抑制剂组合物和在哺乳动物中抑制血管生成的方法。
• PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS
  申请人：Aldous Suzanne C.

  公开号：US20100048568A1

  公开（公告）日：2010-02-25

  This invention is directed to a compound of formula (I): wherein R 1 , R 2 , R 3 , R 4 and L 1 are as defined herein, a pharmaceutical composition comprising the compound, and the use of the compound to treat allergic and/or inflammatory disorders, particularly disorders such as allergic rhinitis, asthma and/or chronic obstructive pulmonary disease (COPD).

  本发明涉及一种式(I)的化合物：其中R1、R2、R3、R4和L1如本文所定义，以及包含该化合物的药物组合物，以及使用该化合物治疗过敏和/或炎症性疾病，特别是过敏性鼻炎、哮喘和/或慢性阻塞性肺疾病（COPD）等疾病的用途。
• Pyrimidine hydrazide compounds as PGDS inhibitors
  申请人：Sanofi

  公开号：US08258130B2

  公开（公告）日：2012-09-04

  This invention is directed to a compound of formula (I): wherein R1, R2, R3, R4 and L1 are as defined herein, a pharmaceutical composition comprising the compound, and the use of the compound to treat allergic and/or inflammatory disorders, particularly disorders such as allergic rhinitis, asthma and/or chronic obstructive pulmonary disease (COPD).

  本发明涉及一种式(I)的化合物，其中R1、R2、R3、R4和L1的定义如本文所述，以及包含该化合物的药物组合物，以及使用该化合物治疗过敏和/或炎症性疾病，特别是过敏性鼻炎、哮喘和/或慢性阻塞性肺病（COPD）的用途。
• Thiazolyl Oxime Ethers and Hydrazones as Crop Protection Agents
  申请人：Bayer CropScience AG

  公开号：US20140296289A1

  公开（公告）日：2014-10-02

  Thiazolyl oxime ethers and hydrazones of the formula (I), in which the symbols A, L 1 , L 2 , Y, W, X, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 have the meanings given in the description, and also agrochemically active salts thereof, and their use for controlling phytopathogenic harmful fungi, and also methods for controlling phytopathogenic harmful fungi and processes for preparing compounds of the formula (I).

  本发明涉及公式（I）的噻唑氧肟醚和肼酮，其中符号A、L1、L2、Y、W、X、R1、R2、R3、R4、R5、R6和R7具有描述中给出的含义，以及其农业化学活性盐，以及它们用于控制植物病原真菌的使用方法，以及用于控制植物病原真菌的方法和制备公式（I）化合物的方法。