N-isopropylheptanamide | 541529-32-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N-isopropylheptanamide
• 英文别名: N-propan-2-ylheptanamide
• CAS: 541529-32-2
• 化学式: C₁₀H₂₁NO
• 分子量: 171.283
• InChiKey: XLWHRRMFWXPDIB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  12
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  庚醛 在 苯甲酰甲酸 作用下， 以 二氯甲烷 、 Petroleum ether 为溶剂， 生成 N-isopropylheptanamide
  参考文献：
  名称：

  醛和胺通过光有机催化活化醛而形成一锅酰胺键

  摘要：

  描述了一种由醛和胺温和，一锅又环保的酰胺合成方法。最初，醛与偶氮二异丙基二异丙酯的光有机催化反应产生中间体羰基酰亚胺，该中间体可与多种胺反应以提供所需的酰胺。各种单取代或双取代醛的初始可见光介导的活化通常很快，发生在几个小时内。在光催化反应之后，在室温下添加伯胺或在高温下添加仲胺导致相应的酰胺从中等收率到优异的收率而没有差向异构化。该方法学被用于合成抗抑郁和社交焦虑症药物莫氯贝胺。

  DOI：

  10.1021/acs.joc.6b00488

文献信息

• [EN] NUCLEIC ACID CONJUGATES AND USES THEREOF<br/>[FR] CONJUGUÉS DE TYPE ACIDE NUCLÉIQUE ET LEURS UTILISATIONS
  申请人：TRANSLATE BIO MA INC

  公开号：WO2018013525A1

  公开（公告）日：2018-01-18

  Provided herein are conjugates comprising targeting moieties such as sugars, folates and cell-penetrating peptides, which can be used for the improved delivery of agents (e.g., nucleic acids, such as oligonucleotides or mRNAs, or other agents) to cells. The invention provides conjugates and compounds comprising targeting moieties, methods for preparing the same, and intermediates useful in their preparation. In another aspect, the present invention provides formulations (e.g., pharmaceutical compositions) comprising the targetting moiety-containing conjugates and compounds. The present invention also provides methods for delivering agents (e.g., nucleic acids such as oligonucleotides or mRNAs) to a cell, methods for treating and/or preventing a disease or condition in a subject, and methods for modulating gene expression in a cell or a subject. Further, provided herein are kits comprising the conjugates, or formulations thereof; and kits for the preparation of conjugates described herein.

  本文提供了包含靶向基团的共轭物，如糖类、叶酸和穿膜肽，可用于改善药物（例如核酸，如寡核苷酸或mRNA，或其他药物）对细胞的传递。该发明提供了包含靶向基团的共轭物和化合物，以及其制备方法和制备过程中有用的中间体。另一方面，本发明提供了包含靶向基团的共轭物和化合物的配方（例如，药物组合物）。本发明还提供了将药物（例如核酸，如寡核苷酸或mRNA）传递至细胞的方法，用于治疗和/或预防受试者疾病或状况的方法，以及用于调节细胞或受试者基因表达的方法。此外，本文提供了包含这些共轭物或其配方的试剂盒；以及用于制备本文所述共轭物的试剂盒。
• Synthesis of Aliphatic Amides through a Photoredox Catalyzed Radical Carbonylation Involving Organosilicates as Alkyl Radical Precursors
  作者：Alex Cartier、Etienne Levernier、Anne‐Lise Dhimane、Takahide Fukuyama、Cyril Ollivier、Ilhyong Ryu、Louis Fensterbank

  DOI：10.1002/adsc.202000314

  日期：2020.5.26

  Alkyl radicals, from primary to tertiary, formed by photocatalyzed oxidation of organosilicates, are involved efficiently in radical carbonylation with carbon monoxide (CO), in the presence of various amines and CCl4, leading to a variety of amides in moderate to good yields.

  在各种胺和CCl 4的存在下，通过有机硅酸盐的光催化氧化形成的伯基到伯基的烷基有效地参与一氧化碳（CO）的自由基羰基化反应，从而以中等至良好的收率生成了各种酰胺。
• Direct amide bond formation from carboxylic acids and amines using activated alumina balls as a new, convenient, clean, reusable and low cost heterogeneous catalyst
  作者：Sabari Ghosh、Asim Bhaumik、John Mondal、Amit Mallik、Sumita Sengupta (Bandyopadhyay)、Chhanda Mukhopadhyay

  DOI：10.1039/c2gc35880h

  日期：——

  For the first time, we have used activated alumina balls (3–5 mm diameter) for amide synthesis from carboxylic acids (unactivated) and amines (unactivated) under neat reaction conditions that produce no toxic by-products and has the advantages of being low-cost, easily available, heterogeneous, reusable and environmentally benign with no troublesome/hazardous disposal of the catalyst.

  我们首次使用活性氧化铝球（直径3–5毫米） 酰胺 合成自 羧酸 （未激活）和 胺类 （未活化），在不产生有毒副产物的纯净反应条件下，具有低成本，易于获得，异构，可重复使用且对环境无害的优点，而不会造成麻烦/危险的处置 催化剂。
• [EN] NOVEL CYANOGUANIDINES<br/>[FR] NOUVELLES CYANOGUANIDINES
  申请人：TOPOTARGET AS

  公开号：WO2009086835A1

  公开（公告）日：2009-07-16

  This application discloses novel cyanoguanidines of the formula (I) wherein A is selected from -C(=O)-, -S(=O)2-, -C(=S)-, and -P(=O)(R5)-, wherein R5 is selected from C1-6-alkyl, C1-6-alkoxy, and hydroxy; B is selected from a single bond, -O-, -NR6- and -C(=O)-NR6-, wherein R6 is selected from hydrogen, optionally substituted C1-12-alkyl, optionally substituted C1-12-alkenyl, optionally substituted aryl, optionally substituted heterocyclyl, and optionally substituted heteroaryl; and m is an integer of 0-12 and n is an integer of 0-12, wherein the sum m+n is 1-20; and R1 is selected from optionally substituted heteroaryl; and pharmaceutically acceptable salts thereof, and prodrugs thereof. The compounds are usefuld for use as a medicament for the treatment of a disease or a condition caused by an elevated level of nicotinamide phosphoribosyltransferase (NAMPRT).

  该申请公开了一种新型氰胍啶化合物，其化学式为（I），其中A从-C（=O）-，-S（=O）2-，-C（=S）-和-P（=O）（R5）-中选择，其中R5选择自C1-6-烷基，C1-6-烷氧基和羟基；B从单键，-O-，-NR6-和-C（=O）-NR6-中选择，其中R6选择自氢，可选择地取代的C1-12-烷基，可选择地取代的C1-12-烯基，可选择地取代的芳基，可选择地取代的杂环烷基和可选择地取代的杂环芳基；m为0-12的整数，n为0-12的整数，其中m+n之和为1-20；R1选择自可选择地取代的杂环芳基；以及其药学上可接受的盐和前药。这些化合物可用作治疗由烟酰胺磷酸核糖转移酶（NAMPRT）水平升高引起的疾病或病况的药物。
• Copper and N-Heterocyclic Carbene-Catalyzed Oxidative Amidation of Aldehydes with Amines
  作者：Anudeep Kumar Narula、Ashmita Singh

  DOI：10.1055/a-1343-5203

  日期：2021.4

  one-pot two-step oxidative process has been developed for the tert-butyl hydroperoxide mediated transformation of aldehydes and amines into amides catalyzed by copper(I) iodide and an N-heterocyclic carbene. The process is additive-free and does not require the amine to be transformed into its hydrochloride salts. The method is simple and practicable, has a broad substrate scope, and uses economical, feasible

  已经开发了一种一锅两步氧化方法，用于叔丁基氢过氧化物介导的碘化铜（I）和N-杂环卡宾催化的醛和胺向酰胺的转化。该方法是无添加剂的，不需要将胺转化为其盐酸盐。该方法简单实用，底物范围广，使用经济，可行，试剂丰富。