L-histidine | 1062610-66-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: L-histidine
• 英文别名: (3S)-3-amino-3-(1H-imidazol-5-yl)propanoic acid
• CAS: 1062610-66-5
• 化学式: C₆H₉N₃O₂
• 分子量: 155.156
• InChiKey: BBGYWNCGOUEKBO-BYPYZUCNSA-N

物化性质

• 沸点：
  458.9±35.0 °C(Predicted)
• 密度：
  1.418±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -3.8
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  92
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  L-histidine 、 吡哆醛 、 zinc(II) oxide 在 sodium hydroxide 作用下， 以 甲醇 、 水 为溶剂， 生成 Zn(pdx-L-his) pdx: pyridoxal, L-his: L-histidine
  参考文献：
  名称：

  Coordination modes of histidine. 2. Stereochemistry of the reaction between histidine derivatives and pyridoxal analogs conformational properties of zinc(II) complexes of histidine Schiff bases

  摘要：

  DOI：

  10.1021/ja00411a013

文献信息

• RAPAFUCIN DERIVATIVE COMPOUNDS AND METHODS OF USE THEREOF
  申请人：The Johns Hopkins University

  公开号：US20210094933A1

  公开（公告）日：2021-04-01

  The present disclosure provides macrocyclic compounds inspired by the immunophilin ligand family of natural products FK506 and rapamycin. The generation of a Rapafucin library of macrocyles that contain FK506 and rapamycin binding domains should have great potential as new leads for developing drugs to be used for treating diseases.

  本公开提供了受免疫蛋白配体家族FK506和雷帕霉素天然产物启发的大环化合物。生成包含FK506和雷帕霉素结合结构域的Rapafucin大环化合物库，应具有作为治疗疾病新药的潜力。
• Rapafucin derivative compounds and methods of use thereof
  申请人：The Johns Hopkins University

  公开号：US11066416B2

  公开（公告）日：2021-07-20

  The present disclosure provides macrocyclic compounds inspired by the immunophilin ligand family of natural products FK506 and rapamycin. The generation of a Rapafucin library of macrocyles that contain FK506 and rapamycin binding domains should have great potential as new leads for developing drugs to be used for treating diseases.

  本公开提供了受天然产物 FK506 和雷帕霉素的免疫嗜蛋白配体家族启发的大环化合物。由含有 FK506 和雷帕霉素结合结构域的大环化合物组成的雷帕霉素库，作为开发用于治疗疾病的药物的新线索，具有巨大的潜力。
• SYNTHETIC COMPOUND FOR IMPROVING EFFICIENCY OF TRANSFECTION
  申请人：Klinikum der Universität München

  公开号：EP3436045A1

  公开（公告）日：2019-02-06
• [EN] METABOLIC ENGINEERING OF VIOMYCIN BIOSYNTHESIS<br/>[FR] GENIE METABOLIQUE DE BIOSYNTHESE DE LA VIOMYCINE
  申请人：WISCONSIN ALUMNI RES FOUND

  公开号：WO2005021586A2

  公开（公告）日：2005-03-10

  The invention provides a nucleic acid molecule comprising at least a functional fragment of the viomycin biosynthetic gene cluster, functional proteins encoded by the cluster, expression cassettes and recombinant host cells comprising a functional fragment of the viomycin cluster, and methods for generating biologically active agents using the nucleic acid molecules of the present invention.
• [EN] SYNTHETIC COMPOUND FOR IMPROVING EFFICIENCY OF TRANSFECTION<br/>[FR] COMPOSÉ SYNTHÉTIQUE POUR AMÉLIORER L'EFFICACITÉ DE LA TRANSFECTION
  申请人：KLINIKUM DER UNIVERSITÄT MÜNCHEN

  公开号：WO2017167870A1

  公开（公告）日：2017-10-05

  The invention concerns a synthetic compound for enabling transfection of eukaryotic cells by means of an amphiphilic block copolymer which synthetic compound comprises a peptide residue having at least one targeting sequence and a nucleic acid binding sequence which nucleic acid binding sequence comprises or consists of at least four consecutive amino acid residues which are positively charged at pH 7.4, wherein the targeting sequence is any sequence that causes a direction of the sequence to a position or a structure inside or on the surface of eukaryotic cells, characterized in that the synthetic compound further comprises a hydrophobic moiety covalently linked to the peptide residue, wherein the hydrophobic moiety comprises or consists of lipoic acid residue, lipoamide residue, a tetradecyl residue, a cholesteryl residue, or a further peptide residue having a sequence with more than 40% amino acid residues with hydrophobic side chains.