1-硝基-3-(异丙烯基)苯 | 64416-49-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1-硝基-3-(异丙烯基)苯
• 英文名称: 2-(3-nitrophenyl)propene
• 英文别名: 3-(1-methylethenyl)nitrobenzene；Benzene, 1-(1-methylethenyl)-3-nitro-；1-nitro-3-prop-1-en-2-ylbenzene
• CAS: 64416-49-5
• 化学式: C₉H₉NO₂
• 分子量: 163.176
• InChiKey: WMTKDRPCKOBHGI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  45.8
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-硝基-3-(异丙烯基)苯 在 铁粉 、 溶剂黄146 作用下， 以 乙醇 为溶剂， 反应 2.0h， 以59%的产率得到3-(prop-1-en-2-yl)aniline
  参考文献：
  名称：

  苯丙氨酸衍生的三氟甲基酮的合成和用于基于肽的氧化催化

  摘要：

  我们报告了苯丙氨酸衍生的三氟甲基酮的合成，用于氧化催化原位生成二恶英。该合成的关键特征包括使用掩蔽的酮策略和Negishi交叉偶联来访问母体氨基酸。所述衍生物可以容易地掺入用于氧化化学的肽中，并表现出良好的稳定性和反应性。

  DOI：

  10.1016/j.bmc.2016.07.012
• 作为产物：
  描述：

  间异丙基硝基苯 在 四氯化碳 、 N-溴代丁二酰亚胺(NBS) 、 过氧化苯甲酰 作用下， 生成 1-硝基-3-(异丙烯基)苯
  参考文献：
  名称：

  A Spiral Curriuculm for Hypnosis Training

  摘要：

  Although hypnosis has been used for centuries, there are few reports of systematic, professional training. The most thorough codification of instructional content is the Standards of Training in Clinical Hypnosis (SOTCH) (Elkins & Hammond, 1994), endorsed by The American Society of Clinical Hypnosis (ASCH), and The Society of Clinical and Experimental Hypnosis (SCEH) for annual workshops. This curriculum is organized around two assumptions: training is presented to adult professionals who know their own objectives; and each participant has a favorite leaming style that should be accommodated. The workshop follows the content and time recommendations of the SOTCH. Some content is scheduled with spaced opportunity for practice. Concepts are organized in a spiral pattern, then presented and reviewed several times, each time in more detail, and in ways that accommodate different learning styles.

  DOI：

  10.1080/00029157.2002.10403509

文献信息

• Metal-Free, Aerobic Dioxygenation of Alkenes Using Simple Hydroxamic Acid Derivatives
  作者：Benjamin C. Giglio、Valerie A. Schmidt、Erik J. Alexanian

  DOI：10.1021/ja206306f

  日期：2011.8.31

  The dioxygenation of alkenes using molecular oxygen and a simple hydroxamic acid derivative has been achieved. The reaction system consists of readily prepared methyl N-hydroxy-N-phenylcarbamate and molecular oxygen with a radical initiator, offering an alternative to common dioxygenation processes catalyzed by precious transition metals. This transformation capitalizes on the unique reactivity profile

  已经实现了使用分子氧和简单的异羟肟酸衍生物对烯烃进行双氧化。该反应体系由易于制备的 N-羟基-N-苯基氨基甲酸甲酯和分子氧与自由基引发剂组成，为贵过渡金属催化的常见双氧化过程提供了替代方法。这种转变利用了异羟肟酸衍生物在自由基介导的烯烃加成过程中独特的反应性特征。
• Copper−Carbene Complexes as Catalysts in the Synthesis of Functionalized Styrenes and Aliphatic Alkenes
  作者：Hélène Lebel、Michaël Davi、Silvia Díez-González、Steven P. Nolan

  DOI：10.1021/jo061781a

  日期：2007.1.1

  2-propanol. The copper catalysts are not only inexpensive compared to rhodium complexes, but they also exhibit better functional group compatibility with aromatic aldehydes and ketones. Indeed very high yields were obtained for the formation of styrenes containing nitro, trifluoromethyl, amino, and ester groups, as well as for pyridine-, pyrrole-, and indole-substituted alkenes.

  （NHC）-Cu（NHC = N-杂环卡宾）配合物在三甲基甲硅烷基重氮甲烷，三苯基膦和2-丙醇的存在下有效催化了各种脂肪族和芳香族醛和酮的甲基化反应。与铑配合物相比，铜催化剂不仅价格便宜，而且与芳族醛和酮的官能团相容性也更好。实际上，对于形成含有硝基，三氟甲基，氨基和酯基的苯乙烯，以及吡啶，吡咯和吲哚取代的烯烃，都获得了很高的产率。
• Mn(OAc)₃ catalyzed intermolecular oxidative peroxycyclization of naphthoquinone
  作者：Alex Meye Biyogo、Christophe Curti、Hussein El-Kashef、Omar Khoumeri、Thierry Terme、Patrice Vanelle

  DOI：10.1039/c6ra25138b

  日期：——

  Manganese(III) acetate-mediated peroxycyclization between 2-hydroxy-3-methylnaphthoquinone and various alkenes was performed to obtain dihydronaphtho[2,3-c][1,2]dioxine-5,10(3H,10aH)-diones. The reactivity of symmetrical or unsymmetrical 1,1-disubstituted alkenes and monosubstituted alkenes allowed the synthesis of more than 50 original molecules. Focusing on the excellent reactivity of 2-hydroxy-

  进行了乙酸锰（III）在2-羟基-3-甲基萘醌与各种烯烃之间的过氧环化反应，得到二氢萘[2,3- c ] [1,2]二恶英-5,10 （3H，10aH）-二酮。对称或不对称的1，1-二取代的烯烃和单取代的烯烃的反应性允许合成超过50个原始分子。着眼于2-羟基-3-甲基萘醌的出色反应性，我们描述了Mn（OAc）3的第一个例子与硝基取代的烯烃的反应性。讨论了合成产物的范围，局限性和立体化学。从单取代的烯烃开始，观察到一对非对映异构体的不稳定性，导致开环。
• 1-Methyl-1-vinyl- and 1-Methyl-1-(prop-2-enyl)silacyclobutane: Reagents for Palladium-Catalyzed Cross-Coupling Reactions of Aryl Halides
  作者：Scott E. Denmark、Zhigang Wang

  DOI：10.1055/s-2000-6292

  日期：——

  1-Methyl-1-vinylsilacyclobutane (1) and 1-methyl-1-(prop-2-enyl)silacyclobutane (2) undergo rapid and high yielding cross-coupling with aromatic halides. Many different substituents and patterns on the aromatic moiety are tolerated. All reactions can be run at room temperature and require the presence of tetrabutylammonium fluoride and Pd(dba)2. Both silacyclobutanes can be made in one step from commercially available precursors.

  1-甲基-1-乙烯基硅环丁烷（1）和1-甲基-1-(丙-2-烯基)硅环丁烷（2）与芳香卤化物发生快速且高产率的交叉偶联反应。对芳香基的许多不同取代基和结构模式均可耐受。所有反应均可在室温下进行，并需要四丁基氟铵和Pd(dba)2的存在。这两种硅环丁烷均可通过商业可得的前体在一步骤中合成。
• [EN] HETEROARYL COMPOUNDS USEFUL AS RAF KINASE INHIBITORS<br/>[FR] COMPOSÉS HÉTÉROARYLES UTILES EN TANT QU'INHIBITEURS DE KINASE RAF
  申请人：BIOGEN IDEC INC

  公开号：WO2010078408A1

  公开（公告）日：2010-07-08

  The present invention provides compounds of formula (I) useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf -mediated diseases.

  本发明提供了一种化合物，其化学式为（I），可用作Raf蛋白激酶的抑制剂。本发明还提供了这些化合物的组合物，以及治疗Raf介导疾病的方法。