N-methyl-N-Boc-aminoethanol O-allyl ether | 1289375-88-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-methyl-N-Boc-aminoethanol O-allyl ether
• 英文别名: tert-butyl N-methyl-N-(2-prop-2-enoxyethyl)carbamate
• CAS: 1289375-88-7
• 化学式: C₁₁H₂₁NO₃
• 分子量: 215.293
• InChiKey: CNYWDBWJQHUANH-UHFFFAOYSA-N

物化性质

• 沸点：
  270.5±19.0 °C(Predicted)
• 密度：
  0.968±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  15
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  38.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-methyl-N-Boc-aminoethanol O-allyl ether 在 硫酸 、 糖精 作用下， 以 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  Ugi amine-derived P,N- and P,P-ligands with N-alkyltriethoxysilyl tethers: synthesis and evaluation of mesoporous silica-supported Pd complexes in asymmetric allylic substitution reactions

  摘要：

  A facile approach to the synthesis of several types of chiral P,N- and P,P-ligands bearing triethoxysilyl groups starting from N,N-diemthyl-1-ferrocenylethylamine (Ugi amine) has been developed. Allyl palladium complexes of these ligands have been prepared, characterized, and grafted on mesoporous silica. The resulting silica-supported complexes have been shown to catalyze asymmetric allylic alkylation and aminations reactions with moderate enantioselectivities. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.01.025
• 作为产物：
  描述：

  二碳酸二叔丁酯 在 sodium hydride 、 碳酸氢钠 作用下， 以 四氢呋喃 、 水 、 paraffin oil 为溶剂， 反应 23.33h， 生成 N-methyl-N-Boc-aminoethanol O-allyl ether
  参考文献：
  名称：

  Ugi amine-derived P,N- and P,P-ligands with N-alkyltriethoxysilyl tethers: synthesis and evaluation of mesoporous silica-supported Pd complexes in asymmetric allylic substitution reactions

  摘要：

  A facile approach to the synthesis of several types of chiral P,N- and P,P-ligands bearing triethoxysilyl groups starting from N,N-diemthyl-1-ferrocenylethylamine (Ugi amine) has been developed. Allyl palladium complexes of these ligands have been prepared, characterized, and grafted on mesoporous silica. The resulting silica-supported complexes have been shown to catalyze asymmetric allylic alkylation and aminations reactions with moderate enantioselectivities. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.01.025

文献信息

• WO2020051498A5
  申请人：——

  公开号：WO2020051498A5

  公开（公告）日：2022-09-13
• COMPOSITIONS AND METHODS FOR THE TREATMENT OF VIRAL INFECTIONS
  申请人：Cidara Therapeutics, Inc.

  公开号：US20210220478A1

  公开（公告）日：2021-07-22

  Compositions and methods for the treatment of viral infections include conjugates containing inhibitors of viral neuraminidase (e.g., zanamivir, peramivir, or analogs thereof) linked to an Fc monomer, an Fc domain, and Fc-binding peptide, an albumin protein, or albumin-binding peptide. In particular, conjugates can be used in the treatment of viral infections (e.g., influenza viral infections).
• [EN] COMPOSITIONS AND METHODS FOR THE TREATMENT OF VIRAL INFECTIONS<br/>[FR] COMPOSITIONS ET PROCÉDÉS POUR LE TRAITEMENT D'INFECTIONS VIRALES
  申请人：CIDARA THERAPEUTICS INC

  公开号：WO2021046549A1

  公开（公告）日：2021-03-11

  Compositions and methods for the treatment of viral infections include conjugates containing inhibitors of viral neuraminidase (e.g., zanamivir, peramivir, or analogs thereof) linked to an Fc monomer, an Fc domain, and Fc-binding peptide, an albumin protein, or albumin-binding peptide. In particular, conjugates can be used in the treatment of viral infections (e.g., influenza viral infections).