N-((1-(3-(triethoxysilyl)propyl)-1H-1,2,3-triazol-4-yl)methyl)phthalimide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: N-((1-(3-(triethoxysilyl)propyl)-1H-1,2,3-triazol-4-yl)methyl)phthalimide
• 化学式: C₂₀H₂₈N₄O₅Si
• 分子量: 432.552
• InChiKey: XREOIJXZCDSDIF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.51
• 重原子数：
  30.0
• 可旋转键数：
  12.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  95.78
• 氢给体数：
  0.0
• 氢受体数：
  8.0

反应信息

• 作为反应物：
  描述：

  三乙醇胺 、 N-((1-(3-(triethoxysilyl)propyl)-1H-1,2,3-triazol-4-yl)methyl)phthalimide 在 potassium hydroxide 作用下， 以 甲苯 为溶剂， 反应 5.0h， 以89%的产率得到N-((1-(3-(silatranyl)propyl)-1H-1,2,3-triazol-4-yl)methyl)phthalimide
  参考文献：
  名称：

  Design and syntheses of novel fluorescent organosilicon-based chemosensors through click silylation: detection of biogenic amines

  摘要：

  首次使用有机硅基化学传感器识别生物胺的报告。

  DOI：

  10.1039/c4ra02270j
• 作为产物：
  描述：

  邻苯二甲酸亚胺 在 溴化三(三苯基磷)铜 、 potassium carbonate 、 三乙胺 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 、 甲苯 为溶剂， 反应 5.0h， 生成 N-((1-(3-(triethoxysilyl)propyl)-1H-1,2,3-triazol-4-yl)methyl)phthalimide
  参考文献：
  名称：

  Synthesis of polyfunctional triethoxysilanes by ‘click silylation’

  摘要：

  The copper-catalyzed 'click silylation' has been exploited for the chemical modification of gamma-azidopropyltriethoxysilane (AzPTES) with a wide range of terminal alkynes (la-lv) in a one-pot operation. The novel 1,2,3-triazole-triethoxysilane derivatives (2a-2v) were synthesized by this procedure and comprehensively characterized by IR spectra, H-1 and C-13 NMR, and HRMS studies. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.12.037

文献信息

• Synthesis of novel 1,2,3-triazole based silatranes via “click silylation”
  作者：Gurjaspreet Singh、Satinderpal Singh Mangat、Jandeep Singh、Aanchal Arora、Mridula Garg

  DOI：10.1016/j.jorganchem.2014.07.014

  日期：2014.10

  A single step reaction for the synthesis of novel 1,2,3-triazole based silatranes (TBS)-scaffolds (2a–2o) using polyfunctionalised organotriethoxysilanes (1a–1l) as precursors is described. The synthesized silatranes are the first compounds of this type and hydrolytically more stable than their open chain analogues. The structures of 2a–2o were characterized by IR, NMR (1H and 13C) and mass spectroscopy

  描述了使用多官能化有机三乙氧基硅烷（1a - 1l）作为前体来合成新型1,2,3-三唑基硅烷基（TBS）-支架（2a - 2o）的一步反应。合成的硅杂环丁烷是这种类型的第一种化合物，并且比其开链类似物在水解上更稳定。2a - 2o的结构通过IR，NMR（1 H和13 C）和质谱研究表征。
• Synthesis of polyfunctional triethoxysilanes by ‘click silylation’
  作者：Gurjaspreet Singh、Satinderpal Singh Mangat、Jandeep Singh、Aanchal Arora、Ramesh K. Sharma

  DOI：10.1016/j.tetlet.2013.12.037

  日期：2014.1

  The copper-catalyzed 'click silylation' has been exploited for the chemical modification of gamma-azidopropyltriethoxysilane (AzPTES) with a wide range of terminal alkynes (la-lv) in a one-pot operation. The novel 1,2,3-triazole-triethoxysilane derivatives (2a-2v) were synthesized by this procedure and comprehensively characterized by IR spectra, H-1 and C-13 NMR, and HRMS studies. (C) 2013 Elsevier Ltd. All rights reserved.
• Design and syntheses of novel fluorescent organosilicon-based chemosensors through click silylation: detection of biogenic amines
  作者：Gurjaspreet Singh、Satinderpal Singh Mangat、Hemant Sharma、Jandeep Singh、Aanchal Arora、Ajay Pal Singh Pannu、Narinder Singh

  DOI：10.1039/c4ra02270j

  日期：——

  First report on the use of organosilicon-based chemosensors for the recognition of biogenic amines.

  首次使用有机硅基化学传感器识别生物胺的报告。