2-<(4-methoxyphenyl)thio>-1-aminoethane | 36155-36-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-<(4-methoxyphenyl)thio>-1-aminoethane
• 英文别名: 2-((4-methoxyphenyl)thio)ethan-1-amine；2-[(4-methoxyphenyl)thio]ethanamine；2-(4-methoxyphenylthio)ethanamine；2-(4-methoxyphenylthio)ethylamine；2-(4-methoxy-phenylsulfanyl)-ethylamine；2-Amino-1-(4-methoxy-phenylmercapto)-aethan；Ethanamine, 2-[(4-methoxyphenyl)thio]-；2-(4-methoxyphenyl)sulfanylethanamine
• CAS: 36155-36-9
• 化学式: C₉H₁₃NOS
• 分子量: 183.274
• InChiKey: GXZCTRPMQTYSHX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  60.6
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2930909090

反应信息

• 作为反应物：
  描述：

  2-<(4-methoxyphenyl)thio>-1-aminoethane 在 对甲苯磺酸 、 三乙胺 作用下， 以 二氯甲烷 、 甲苯 为溶剂， 反应 6.5h， 生成 methyl 7-methoxy-2,3-dihydrobenzo[f][1,4]thiazepine-4(5H)-carboxylate
  参考文献：
  名称：

  N-酰基亚胺基环化反应合成2,3,4,5-四氢苯并[1,4]噻嗪类

  摘要：

  我们报告了7-甲氧基-2,3,4,5-四氢苯并[1,4]硫氮平的有效和可扩展的合成，该生物活性分子如JTV-519和S107的核心结构。该合成路线从4-甲氧基硫酚开始，并通过亚胺基环化进行，分四个步骤提供目标产物，总收率达68％，与以前公布的工艺相比有实质性的改进。还提供了通过酰基亚胺环闭环合成四氢苯并[1,4]噻氮平的另外九个实例。

  DOI：

  10.1021/acs.oprd.7b00260
• 作为产物：
  描述：

  N-<2-<(4-methoxyphenyl)thio>ethyl>propanamide 在 盐酸 作用下， 反应 3.0h， 生成 2-<(4-methoxyphenyl)thio>-1-aminoethane
  参考文献：
  名称：

  Elimination-addition reactions of 3-[2-(arylthio)ethyl]sydnones. Displacement of the sulfide by an ether group

  摘要：

  DOI：

  10.1021/jo00141a033

文献信息

• AGENTS FOR TREATING DISORDERS INVOLVING MODULATION OF RYANODINE RECEPTORS
  申请人：LES LABORATOIRES SERVIER

  公开号：US20130281512A1

  公开（公告）日：2013-10-24

  The present invention relates to 1,4-benzothiazepine derivatives and their use to treat conditions, disorders and diseases associated with ryanodine receptors (RyRs) that regulate calcium channel functioning in cells. The invention also discloses pharmaceutical compositions comprising the compounds and uses thereof to treat diseases and conditions associated with RyRs, in particular cardiac, musculoskeletal and central nervous system (CNS) disorders.

  本发明涉及1,4-苯并噻吩啉衍生物及其用于治疗与调节细胞内钙通道功能的利纳碱受体（RyRs）相关的病症、紊乱和疾病。该发明还披露了包含这些化合物的药物组合物，并用于治疗与RyRs相关的疾病和症状，特别是心脏、肌肉骨骼和中枢神经系统（CNS）紊乱。
• PROCESS FOR PREPARING BENZOTHIAZEPINES FROM GAMMA-AMINOALKYLBENZENES
  申请人：Deng Shixian

  公开号：US20090227788A1

  公开（公告）日：2009-09-10

  The invention provides a process for preparing a 2,3,4,5-tetrahydro[1,4]benzothiazepine of formula: by reacting a [2-(acylaminoethyl)thio]arene of formula with an aldehyde or a multimer thereof, and with an acid. The invention also provides for first reacting the [2-(acylaminoethyl)thio]arene with the aldehyde or multimer thereof and a base to form an [N-hydroxymethyl-2-[acylaminoethyl)thio]arene of formula then treating the [N-hydroxymethyl-2-(acylaminoethyl)thio]arene with the acid to form the 2,3,4,5-tetrahydro[1,4]benzothiazepine.

  该发明提供了一种制备2,3,4,5-四氢[1,4]苯并噻吩的方法，通过将式中的[2-(酰胺基乙基)硫]芳烃与醛或其多聚物以及酸反应。该发明还提供了首先将[2-(酰胺基乙基)硫]芳烃与醛或其多聚物以及碱反应以形成式的[N-羟甲基-2-(酰胺基乙基)硫]芳烃，然后用酸处理[N-羟甲基-2-(酰胺基乙基)硫]芳烃以形成2,3,4,5-四氢[1,4]苯并噻吩。
• [EN] PHOSPHINYL AMIDINE COMPOUNDS, METAL COMPLEXES, CATALYST SYSTEMS, AND THEIR USE TO OLIGOMERIZE OR POLYMERIZE OLEFINS<br/>[FR] COMPOSÉS DE PHOSPHINYLAMIDINE, COMPLEXES DE MÉTAL, SYSTÈMES DE CATALYSEUR, ET LEUR UTILISATION POUR OLIGOMÉRISER OU POLYMÉRISER DES OLÉFINES
  申请人：CHEVRON PHILLIPS CHEMICAL CO

  公开号：WO2011082192A1

  公开（公告）日：2011-07-07

  N2-phosphinyl amidine compounds, N2-phosphinyl amidinates, N2-phosphinyl amidine metal salt complexes, N2-phosphinyl amidinate metal salt complexes are described. Methods for making N2-phosphinyl amidine compounds, N2-phosphinyl amidinates, N2-phosphinyl amidine metal salt complexes, and N2-phosphinyl amidinate metal salt complexes are also disclosed. Catalyst systems utilizing the N2-phosphinyl amidine metal salt complexes and N2-phosphinyl amidinate metal salt complexes are also disclosed along with the use of the N2-phosphinyl amidine compounds, N2-phosphinyl amidinates, N2-phosphinyl amidine metal salt complexes, and N2-phosphinyl amidinate metal salt complexes for the oligomerization and/or polymerization of olefins.

  描述了N2-膦胺化合物、N2-膦胺酸盐、N2-膦胺金属盐络合物、N2-膦胺酸盐金属盐络合物。还公开了制备N2-膦胺化合物、N2-膦胺酸盐、N2-膦胺金属盐络合物和N2-膦胺酸盐金属盐络合物的方法。还公开了利用N2-膦胺金属盐络合物和N2-膦胺酸盐金属盐络合物的催化剂系统，以及利用N2-膦胺化合物、N2-膦胺酸盐、N2-膦胺金属盐络合物和N2-膦胺酸盐金属盐络合物进行烯烃的寡聚和/或聚合的用途。
• [EN] AGENTS FOR TREATING DISORDERS INVOLVING MODULATION OF RYANODINE RECEPTORS<br/>[FR] AGENTS POUR LE TRAITEMENT DE TROUBLES METTANT EN JEU LA MODULATION DE RÉCEPTEURS DE RYANODINE
  申请人：SERVIER LAB

  公开号：WO2013156505A1

  公开（公告）日：2013-10-24

  The present invention relates to 1,4-benzothiazepine derivatives and their use to treat conditions, disorders and diseases associated with ryanodine receptors (RyRs) that regulate calcium channel functioning in cells. The invention also discloses pharmaceutical compositions comprising the compounds and uses thereof to treat diseases and conditions associated with RyRs, in particular cardiac, musculoskeletal and central nervous system (CNS) disorders.

  本发明涉及1,4-苯并噻吩衍生物及其用于治疗与调节细胞中钙离子通道功能的莱诺定受体（RyRs）相关的疾病、疾病和病症。本发明还披露了包含该化合物的药物组合物及其用于治疗与RyRs相关的疾病和病症，特别是心脏、肌肉骨骼和中枢神经系统（CNS）疾病和病症。
• [EN] PROCESS FOR PREPARING BENZOTHIAZEPINES FROM GAMMA-AMINOALKYLBENZENES<br/>[FR] PROCÉDÉ POUR PRÉPARER DES BENZOTHIAZÉPINES À PARTIR DE GAMMA-AMINOALKYLBENZÈNES
  申请人：ARMGO PHARMA INC

  公开号：WO2009111463A1

  公开（公告）日：2009-09-11

  The invention provides a process for preparing a 2,3,4,5-tetrahydro[1,4]benzothiazepine of formula: [I] by reacting a [2-(acylaminoethyl)thio]arene of formula [II] with an aldehyde or a multimer thereof, and with an acid. The invention also provides for first reacting the [2-(acylaminoethyl)thio]arene with the aldehyde or multimer thereof and a base to form an [N-hydroxymethyl-2-[acylaminoethyl)thio]arene of formula [III]; then treating the [N-hydroxymethyl-2-(acylaminoethyl)thio]arene with the acid to form the 2,3,4,5-tetrahydro[1,4]benzothiazepine.

  本发明提供了一种制备式为[I]的2,3,4,5-四氢[1,4]苯并噻吩的方法，该方法通过将式[II]的[2-(酰胺基乙基)硫]芳烃与醛或其多聚物以及酸反应而得到。本发明还提供首先将[2-(酰胺基乙基)硫]芳烃与醛或其多聚物以及碱反应以形成式[III]的[N-羟甲基-2-(酰胺基乙基)硫]芳烃；然后用酸处理[N-羟甲基-2-(酰胺基乙基)硫]芳烃以形成2,3,4,5-四氢[1,4]苯并噻吩。